Details for Patent: 5,703,110

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Summary for Patent: 5,703,110

Title:	Benzimidazole derivatives, their production and use
Abstract:	Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
Inventor(s):	Naka; Takehiko (Kobe, JP), Nishikawa; Kohei (Kyoto, JP), Kato; Takeshi (Higashiosaka, JP)
Assignee:	Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:	08/715,100
Patent Claim Types: see list of patent claims	Compound; Composition; Use;

Drugs Protected by US Patent 5,703,110

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

Foreign Priority and PCT Information for Patent: 5,703,110

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Japan	2-113148	Apr 27, 1990
Japan	2-141942	May 30, 1990
Japan	2-208662	Aug 06, 1990
Japan	2-264579	Oct 01, 1990
Japan	2-413679	Dec 24, 1990

International Family Members for US Patent 5,703,110

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0459136	⤷ Sign Up	SPC/GB97/018	United Kingdom	⤷ Sign Up
European Patent Office	0459136	⤷ Sign Up	C970044	Netherlands	⤷ Sign Up
European Patent Office	0459136	⤷ Sign Up	98C0016	Belgium	⤷ Sign Up
European Patent Office	0459136	⤷ Sign Up	8/1998	Austria	⤷ Sign Up
European Patent Office	0459136	⤷ Sign Up	SZ 8/1998	Austria	⤷ Sign Up
European Patent Office	0459136	⤷ Sign Up	19875004	Germany	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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