Details for Patent: 5,753,675

Summary for Patent: 5,753,675

Title:	Quinoline analogs of mevalonolactone and derivatives thereof
Abstract:	Quinoline analogs of mevalonolactone of the following formula are useful as anti-cholesterol synthesis agents: ##STR1## where the substituents are as defined in the specification.
Inventor(s):	Wattanasin; Sompong (Hopatcong, NJ)
Assignee:	Novartis Pharmaceuticals Corporation (East Hanover, NJ)
Application Number:	07/498,301
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

United States Patent 5,753,675: A Detailed Analysis

Introduction

United States Patent 5,753,675, titled "Quinoline analogs of mevalonolactone and derivatives thereof," is a patent that describes a class of compounds useful as anti-cholesterol synthesis agents. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Patent Overview

The patent, issued to the assignees, describes quinoline analogs of mevalonolactone, which are designed to inhibit cholesterol synthesis. These compounds are detailed in the patent's claims and descriptions, highlighting their chemical structures, synthesis methods, and pharmaceutical applications[4][5].

Scope of the Patent

The scope of the patent is defined by the specific claims made regarding the quinoline analogs. Here are the key aspects:

Chemical Structure

The patent describes quinoline analogs with specific substituents that are crucial for their anti-cholesterol activity. These include various chemical groups such as trifluoromethyl, benzyloxy, ester, phenoxy, and others[4].

Pharmaceutical Use

The compounds are intended for use as anti-cholesterol synthesis agents, making them relevant in the treatment of hypercholesterolemia and related conditions. The patent also mentions their potential use in pharmaceutical compositions[4].

Synthesis Methods

The patent details the methods for synthesizing these quinoline analogs, including the use of various solvents, reagents, and reaction conditions. This includes steps such as elution, evaporation, and filtration[4].

Claims of the Patent

The claims section of the patent is critical as it defines the legal boundaries of the invention. Here are some key claims:

Independent Claims

The patent includes independent claims that describe the quinoline analogs and their use. For example, Claim 1 might describe the general structure of the quinoline analogs, while subsequent claims might specify particular substituents or pharmaceutical compositions[4].

Dependent Claims

Dependent claims further narrow down the scope by specifying additional features or limitations. These could include specific chemical groups, synthesis methods, or dosage forms[4].

Patent Landscape Analysis

To understand the broader context of this patent, a patent landscape analysis is essential.

Defining Scope and Keywords

The first step in a patent landscape analysis is to define the scope and identify relevant keywords. For this patent, keywords might include "quinoline analogs," "mevalonolactone," "anti-cholesterol agents," and "pharmaceutical compositions"[3].

Searching and Organizing Patents

Using databases such as the USPTO's Patent Public Search, Google Patents, or international databases like the European Patent Office's esp@cenet, one can search for patents related to these keywords. Patents can be organized by factors like filing date, assignee, and technology subcategories[1][3].

Identifying Trends and Key Players

Analyzing the patent filings within this domain can reveal trends and key players. For instance, identifying which companies or research institutions are actively filing patents in the area of cholesterol synthesis inhibitors can provide insights into the competitive landscape[3].

Analyzing Citations and Evolution

Studying how patents reference each other can help understand the impact and development of the technology. This includes analyzing the Common Citation Document (CCD) to see how different patent offices have cited the same prior art[1].

Insights from Patent Landscape Analysis

A patent landscape analysis around US Patent 5,753,675 can offer several insights:

Technological Trends

It can reveal ongoing innovations in the field of cholesterol synthesis inhibitors, including new chemical entities and synthesis methods.

Key Players

Identifying key players such as pharmaceutical companies, research institutions, or individual inventors can help in understanding the competitive landscape and potential collaborations or licensing opportunities.

Legal Vulnerabilities

Analyzing the patent landscape can also highlight potential legal vulnerabilities, such as expired patents or those nearing expiration, which could impact the strategic decisions of companies operating in this space[3].

Global Patent Family

To fully understand the scope of this patent, it is important to look at the global patent family. Using tools like the Global Dossier, one can see related applications filed at participating IP Offices, including the IP5 Offices (USPTO, EPO, JPO, KIPO, and CNIPA)[1].

Competitive Landscape

The competitive landscape in the field of cholesterol synthesis inhibitors is dynamic. Companies like Pfizer, Merck, and other pharmaceutical giants have significant patent portfolios in this area. Understanding the patent landscape helps in navigating this competitive space and making informed decisions about research and development, licensing, or litigation[3].

Future Directions

Given the insights from the patent landscape analysis, future directions might include:

Research and Development

Continuing research to develop new quinoline analogs or other cholesterol synthesis inhibitors, potentially leveraging insights from the patent landscape to avoid existing patents.

Licensing and Collaborations

Exploring licensing opportunities or collaborations with key players identified in the patent landscape analysis.

Strategic Decisions

Making strategic decisions about patent filings, enforcement, and potential litigation based on the analysis of the competitive landscape and legal vulnerabilities.

Key Takeaways

• Patent Scope: The patent covers quinoline analogs of mevalonolactone with specific chemical structures and pharmaceutical uses.
• Claims: The claims define the legal boundaries of the invention, including independent and dependent claims.
• Patent Landscape: A comprehensive analysis reveals trends, key players, and potential legal vulnerabilities.
• Global Patent Family: Understanding related applications filed at other IP Offices is crucial.
• Competitive Landscape: The analysis helps in navigating the competitive space and making informed strategic decisions.

FAQs

Q: What is the main subject of United States Patent 5,753,675? A: The main subject is quinoline analogs of mevalonolactone and their use as anti-cholesterol synthesis agents.

Q: How can one conduct a patent landscape analysis for this patent? A: By defining the scope and keywords, searching and organizing patents, identifying trends and key players, analyzing citations and evolution, and generating insights for decisions.

Q: What tools are available for searching patents related to this invention? A: Tools include the USPTO's Patent Public Search, Google Patents, European Patent Office's esp@cenet, and other international databases.

Q: What is the significance of the Global Dossier in patent searching? A: The Global Dossier provides access to the file histories of related applications from participating IP Offices, helping users see the patent family and related data.

Q: How does a patent landscape analysis help in making strategic decisions? A: It provides insights into technological trends, key players, and potential legal vulnerabilities, enabling informed decisions about research, licensing, and litigation.

Cited Sources

1. USPTO - Search for patents.
2. PubChem - Quinoline analogs of mevalonolactone and derivatives thereof.
3. Goldstein Patent Law - How to Do Patent Landscape Analysis.
4. Google Patents - Quinoline analogs of mevalonolactone and derivatives thereof.
5. Justia Patents - Quinoline analogs of mevalonolactone and derivatives thereof.

Drugs Protected by US Patent 5,753,675

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate