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Last Updated: December 22, 2024

Details for Patent: 5,808,146


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Summary for Patent: 5,808,146
Title: Amino acid analogs for tumor imaging
Abstract:The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes including fluorine-18, iodine-123, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77 and bromine-82. In one aspect, the invention features amino acid compounds that have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds show a target to non-target ratio of at least 5:1, are stable in vivo and substantially localized to target within 1 hour after administration. An especially preferred amino acid compound is [.sup.18 F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC). In another aspect, the invention features pharmaceutical compositions comprised of an .alpha.-amino acid moiety attached to either a four, five, or a six member carbon-chain ring. In addition, the invention features analogs of .alpha.-aminoisobutyric acid.
Inventor(s): Goodman; Mark M. (Atlanta, GA), Shoup; Timothy (Decatur, GA)
Assignee: Emory University (Atlanta, GA)
Application Number:08/554,906
Patent Claim Types:
see list of patent claims
Compound;
Patent landscape, scope, and claims:

United States Patent 5,808,146: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 5,808,146, titled "Amino acid analogs for tumor imaging," is a significant patent in the field of medical imaging and oncology. This patent, granted to inventors who developed specific amino acid analogs for tumor imaging, provides valuable insights into the technological and legal landscape of this domain.

Patent Overview

Publication Number and Authority

The patent number is US5808146A, and it was granted by the United States Patent and Trademark Office (USPTO)[4].

Prior Art and Background

The patent builds on prior art related to amino acid compounds, imaging methods, and neoplasm diseases. It introduces novel amino acid analogs designed to target and image tumors more effectively.

Claims

The patent includes several claims that define the scope of the invention. These claims cover the specific amino acid compounds, their synthesis, and their application in tumor imaging. Key claims include:

  • The amino acid compounds themselves, including their chemical structures and compositions.
  • Methods for synthesizing these compounds.
  • The use of these compounds in imaging techniques, particularly for detecting neoplasms[4].

Scope of the Invention

Chemical Compounds

The patent focuses on amino acid analogs, which are chemically modified to enhance their ability to target and image tumors. These compounds include various chemical classes such as carboxylic acids, ethers, and cyclic compounds. The specific chemical structures and their synthesis methods are detailed in the patent[4].

Imaging Methods

The invention involves the use of these amino acid analogs in imaging techniques, particularly for tumor detection. The methods described include the preparation of solutions and mixtures containing these analogs, which are then used in imaging procedures. The patent also mentions the use of radioactive tracers to enhance the imaging process[4].

Patent Claims Analysis

Claim Structure

The claims are structured to cover the broadest possible scope of the invention while ensuring they are specific enough to be enforceable. This includes:

  • Independent Claims: These define the core of the invention, such as the specific amino acid compounds and their use in tumor imaging.
  • Dependent Claims: These build upon the independent claims, providing additional details such as specific synthesis methods and imaging protocols[4].

Claim Scope and Breadth

The claims are crafted to balance breadth and specificity. For example, Claim 1 might broadly cover the amino acid analogs, while subsequent claims narrow down to specific aspects like synthesis steps or imaging techniques. This strategy helps in protecting the invention from infringement while allowing for future innovations within the scope of the patent.

Patent Landscape Analysis

Defining Scope and Keywords

To analyze the patent landscape around US5808146A, one must first define the relevant technology field and keywords. This includes terms like "amino acid analogs," "tumor imaging," "neoplasm diseases," and "radioactive tracers"[5].

Search and Organize Patents

Using databases such as the USPTO's Patent Public Search, Google Patents, and international patent databases like the European Patent Office's esp@cenet, one can retrieve relevant patents. These patents should be organized based on factors like filing date, assignee, and technology subcategories[1][5].

Identify Trends and Key Players

Analyzing the retrieved patents reveals trends in patent filings within the domain of tumor imaging. Key players, such as pharmaceutical companies and research institutions, can be identified by their patent activity and the impact of their patents as measured by citations and legal status[5].

Analyze Citations and Evolution

Studying the citations within the patent family and related patents helps in understanding the technological evolution and the impact of US5808146A. Tools like the Common Citation Document (CCD) can consolidate citation data from multiple offices, providing a comprehensive view of the prior art and subsequent developments[1].

Generate Insights for Decisions

The analysis provides actionable insights for strategic decisions:

  • Competitive Landscape: Understanding the patent activity of competitors helps in identifying white spaces and potential areas for innovation.
  • Legal Vulnerabilities: Analyzing the patent landscape can reveal potential legal vulnerabilities and opportunities for licensing or collaboration[5].

Data Visualization and Analysis

Visual aids like heat maps and citation networks are crucial for revealing trends and interconnections among patents. For example, a heat map can show the geographical distribution of patent filings related to tumor imaging, while a citation network can illustrate the influence of US5808146A on subsequent patents[5].

Insights from Patent Landscape Analysis

Technological Trends

The analysis reveals ongoing innovations in tumor imaging, highlighting key technologies and emerging trends. This includes the development of new amino acid analogs and advanced imaging techniques.

Key Players

Identifying key players such as pharmaceutical companies, research institutions, and individual inventors provides insights into who is driving innovation in this field.

Patent Portfolio Strength

Evaluating the patent portfolio of key players helps in assessing their technological strength and potential for future innovations. This can inform decisions on collaborations, licensing, or competitive strategies.

White Spaces

Analyzing the patent landscape can identify areas with minimal patent activity, indicating potential white spaces for new innovations.

Key Takeaways

  • Patent Scope: US5808146A covers specific amino acid analogs and their use in tumor imaging, with claims structured to balance breadth and specificity.
  • Patent Landscape: The analysis reveals trends, key players, and technological evolution in the domain of tumor imaging.
  • Strategic Insights: The patent landscape analysis provides actionable insights for competitive strategy, legal vulnerabilities, and innovation opportunities.
  • Data Visualization: Tools like heat maps and citation networks are essential for visualizing and analyzing patent data.

FAQs

What is the main focus of US5808146A?

The main focus of US5808146A is the development of amino acid analogs for use in tumor imaging.

How can one conduct a patent landscape analysis for this patent?

One can conduct a patent landscape analysis by defining the scope and keywords, searching and organizing relevant patents, identifying trends and key players, analyzing citations, and generating insights for strategic decisions[5].

What tools are available for searching patents related to US5808146A?

Tools such as the USPTO's Patent Public Search, Google Patents, and international databases like the European Patent Office's esp@cenet are available for searching patents[1].

How do you analyze the claims of US5808146A?

The claims should be analyzed for their structure, scope, and breadth. This includes identifying independent and dependent claims and understanding how they protect the invention[4].

What insights can be gained from a patent landscape analysis around US5808146A?

Insights include understanding technological trends, identifying key players, assessing patent portfolio strength, and identifying white spaces for innovation[5].

Sources

  1. USPTO - Search for patents. Retrieved from https://www.uspto.gov/patents/search
  2. PubChem - Fluorinated amino acids. Retrieved from https://pubchem.ncbi.nlm.nih.gov/patent/US-4695588-A
  3. USPTO - Patent Claims Research Dataset. Retrieved from https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
  4. Google Patents - Amino acid analogs for tumor imaging. Retrieved from https://patents.google.com/patent/US5808146A/ja
  5. Goldstein Patent Law - How to Do Patent Landscape Analysis. Retrieved from https://www.goldsteinpatentlaw.com/how-to-patent-landscape-analysis/

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Drugs Protected by US Patent 5,808,146

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 5,808,146

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 1120497 ⤷  Subscribe
Australia 720738 ⤷  Subscribe
Canada 2237218 ⤷  Subscribe
European Patent Office 0862464 ⤷  Subscribe
Japan 2000500442 ⤷  Subscribe
Japan 2007246535 ⤷  Subscribe
Japan 2011207901 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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