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Last Updated: December 22, 2024

Details for Patent: 5,859,186


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Summary for Patent: 5,859,186
Title: Methods for producing analgesia
Abstract:A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
Inventor(s): Justice; Alan (Sunnyvale, CA), Singh; Tejinder (Palo Alto, CA), Gohil; Kishor Chandra (Richmond, CA), Valentino; Karen L. (San Carlos, CA), Miljanich; George P. (Redwood City, CA)
Assignee: Neurex Corporation (Menlo Park, CA)
Application Number:08/675,354
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

United States Patent 5,859,186: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 5,859,186, titled "Methods for producing analgesia," was granted on January 12, 1999. This patent discloses methods for producing analgesia using omega conopeptides, which are peptides derived from cone snails. Here, we will delve into the scope and claims of this patent and analyze its position within the broader patent landscape.

Scope of the Patent

The patent focuses on methods for administering omega conopeptides to produce analgesia in subjects suffering from nociceptive and neuropathic pain. The scope includes the identification of specific peptides, their administration routes, and the therapeutic effects they provide.

Key Components

  • Omega Conopeptides: The patent highlights the use of specific omega conopeptides, which are known for their potent analgesic properties.
  • Administration Methods: The methods include various routes of administration such as injection, oral, or topical application.
  • Therapeutic Effects: The patent details the analgesic effects of these peptides on different types of pain, including nociceptive and neuropathic pain[2].

Claims of the Patent

The claims of the patent are crucial as they define the legal boundaries of the invention.

Independent Claims

  • Claim 1 typically outlines the broadest scope of the invention, which in this case involves the method of administering an omega conopeptide to a subject to produce analgesia.
  • Subsequent claims narrow down the scope by specifying particular peptides, administration routes, and dosages.

Dependent Claims

  • These claims build upon the independent claims and provide additional specifics, such as the type of pain treated, the dosage regimen, and any additional components that may be used in conjunction with the omega conopeptides.

Patent Landscape Analysis

To understand the position of this patent within the broader patent landscape, we need to conduct a comprehensive patent landscape analysis.

Defining Scope and Keywords

The analysis begins by defining the technology field, which in this case is pain management and analgesia. Relevant keywords include "omega conopeptides," "analgesia," "nociceptive pain," and "neuropathic pain"[3].

Search and Organize Patents

Using patent databases such as the USPTO's Patent Public Search tool, we can retrieve relevant patents based on the chosen keywords. These patents can be organized by factors like filing date, assignee, and technology subcategories. Visual aids like heat maps can help in identifying clusters of activity[4].

Identify Trends and Key Players

The analysis reveals trends in patent filings related to pain management and the use of peptides. Key players in this field include pharmaceutical companies and research institutions that have been actively filing patents related to analgesic peptides.

Analyze Citations and Evolution

By studying how patents reference each other, we can understand the impact and development of the technology. For example, if US Patent 5,859,186 is frequently cited by later patents, it indicates its significance in the field. Tools like the Common Citation Document (CCD) can consolidate prior art cited by multiple offices, providing a comprehensive view of the patent's influence[4].

Generate Insights for Decisions

The analysis provides actionable insights for strategic decisions. For instance, it can help in identifying potential legal vulnerabilities, evaluating the competitive landscape, and guiding research and development efforts.

Competitive Landscape

The competitive landscape in the field of analgesic peptides is dynamic. Other patents and ongoing research focus on various types of peptides and small molecules for pain management. Companies like Pfizer, Merck, and biotech firms are actively involved in this area.

Key Players and Innovations

  • Pharmaceutical Companies: Major pharmaceutical companies have extensive patent portfolios related to pain management.
  • Biotech Firms: Smaller biotech firms often focus on specific types of peptides or novel delivery mechanisms.
  • Research Institutions: Universities and research institutions contribute significantly to the innovation in this field through their patent filings and collaborations with industry partners.

Technological Trends

The patent landscape analysis reveals several technological trends:

Peptide-Based Therapies

There is a growing trend towards peptide-based therapies for pain management due to their specificity and potency.

Delivery Mechanisms

Innovations in delivery mechanisms, such as sustained-release formulations and targeted delivery systems, are also prominent.

Combination Therapies

Combination therapies involving peptides and other analgesic agents are being explored to enhance efficacy and reduce side effects.

Legal and Regulatory Considerations

Understanding the legal and regulatory environment is crucial for navigating the patent landscape.

Patent Expiration

US Patent 5,859,186 has expired, which means that the methods and compositions described are now in the public domain. However, subsequent patents filed by other entities may still be in force.

Litigation and Enforcement

The history of litigation and enforcement related to this patent and similar patents can provide insights into potential legal vulnerabilities and strategies for defense.

Conclusion

US Patent 5,859,186 represents a significant contribution to the field of pain management through the use of omega conopeptides. The patent landscape analysis highlights the dynamic nature of this field, with ongoing innovations and a competitive landscape involving major pharmaceutical companies, biotech firms, and research institutions.

Key Takeaways

  • Scope and Claims: The patent focuses on methods for producing analgesia using omega conopeptides.
  • Patent Landscape: The analysis reveals trends, key players, and technological advancements in pain management.
  • Competitive Landscape: The field is highly competitive with ongoing research and development.
  • Technological Trends: Peptide-based therapies, innovative delivery mechanisms, and combination therapies are prominent trends.
  • Legal Considerations: Understanding patent expiration, litigation, and regulatory environments is essential.

Frequently Asked Questions (FAQs)

1. What is the main subject of US Patent 5,859,186?

The main subject is methods for producing analgesia using omega conopeptides.

2. How do omega conopeptides work in pain management?

Omega conopeptides are potent analgesics that work by targeting specific pain pathways, providing relief from nociceptive and neuropathic pain.

3. What is the current status of US Patent 5,859,186?

The patent has expired, meaning the methods and compositions described are now in the public domain.

4. Who are the key players in the field of analgesic peptides?

Key players include major pharmaceutical companies, biotech firms, and research institutions.

5. What are some of the technological trends in pain management using peptides?

Trends include peptide-based therapies, innovative delivery mechanisms, and combination therapies.

Cited Sources:

  1. Carley, M., Hegde, D., & Marco, A. (2015). What Is the Probability of Receiving a US Patent? Yale Journal of Law & Technology, 17, 203.
  2. US Patent 5,859,186. (1999). Methods for producing analgesia.
  3. Goldstein Patent Law. How to Do Patent Landscape Analysis.
  4. USPTO. Search for patents.

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Drugs Protected by US Patent 5,859,186

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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