Details for Patent: 5,935,946

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Summary for Patent: 5,935,946

Title:	Nucleotide analog composition and synthesis method
Abstract:	The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
Inventor(s):	Munger, Jr.; John D. (Alviso, CA), Rohloff; John C. (Mountain View, CA), Schultze; Lisa M. (San Carlos, CA)
Assignee:	Gilead Sciences, Inc. (Foster City, CA)
Application Number:	08/900,752
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 5,935,946
Patent Claim Types: see list of patent claims	Composition; Compound; Formulation; Use; Dosage form; Process;

Drugs Protected by US Patent 5,935,946

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