Details for Patent: 6,002,008

Summary for Patent: 6,002,008

Title:	Substituted 3-cyano quinolines
Abstract:	This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted; n is 0-1; Y is --NH--, --O--, --S--, or --NR--; R is alkyl of 1-6 carbon atoms; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, ##STR2## R.sub.5 is alkyl which may be optionally substituted, or phenyl which may be optionally substituted; R.sub.6 is hydrogen, alkyl, or alkenyl; R.sub.7 is chloro or bromo R.sub.8 is hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, N-cycloalkylaminoalkyl, N-cycloalkyl-N-alkylaminoalkyl, N,N-dicycloalkylaminoalkyl, morpholino-N-alkyl, piperidino-N-alkyl, N-alkyl-piperidino-N-alkyl, azacycloalkyl-N-alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, carboalkoxy, phenyl, carboalkyl+, chloro, fluoro, or bromo; Z is amino, hydroxy, alkoxy, alkylamino, dialkylamino, morpholino, piperazino, N-alkylpiperazino, or pyrrolidino; m=1-4,q=1-3, and p=0-3; any of the substituents R.sub.1, R.sub.2, R.sub.3, or R.sub.4 that are located on contiguous carbon atoms can together be the divalent radical --O--C(R.sub.8).sub.2 --O--; or a pharmaceutically acceptable salt thereof with the proviso that when Y is --NH--, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, and n is 0, X is not 2-methylphenyl, which are inhibitors of protein tyrosine kinase.
Inventor(s):	Wissner; Allan (Ardsley, NY), Johnson; Bernard D. (Stony Point, NY), Reich; Marvin F. (Suffern, NY), Floyd, Jr.; Middleton B. (Suffern, NY), Kitchen; Douglas B. (Schenectady, NY), Tsou; Hwei-Ru (New City, NY)
Assignee:	American Cyanamid Company (
Application Number:	09/049,718
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

Analyzing the Scope and Claims of United States Patent 6,002,008: A Comprehensive Guide

Introduction

United States Patent 6,002,008, titled "Substituted 3-cyano quinolines," is a patent that has significant implications in the field of chemistry and pharmaceuticals. This article will delve into the details of the patent's scope, claims, and the broader patent landscape surrounding it.

Patent Overview

Title and Abstract

The patent, "Substituted 3-cyano quinolines," involves the synthesis and application of specific quinoline compounds. These compounds are of interest due to their potential therapeutic properties, particularly in the treatment of various diseases.

Inventors and Assignees

The patent was granted to inventors who have contributed to the development of these substituted quinolines. Understanding the inventors and assignees can provide insights into the origins and potential applications of the patented technology[5].

Claims Analysis

Independent and Dependent Claims

The patent includes both independent and dependent claims. Independent claims define the broad scope of the invention, while dependent claims narrow down the scope by adding specific limitations. For example, the independent claims might cover the general structure of the substituted quinolines, while the dependent claims could specify particular substituents or their arrangements[5].

Claim Language and Scope

The language used in the claims is crucial for determining the patent's scope. Metrics such as independent claim length and independent claim count can provide insights into the breadth of the patent. Broader claims can be more contentious but may offer greater protection if upheld. However, narrower claims are often associated with a higher probability of grant and a shorter examination process[3].

Patent Scope and Breadth

Metrics for Measuring Scope

Research has shown that metrics like independent claim length and count can be used to measure patent scope. These metrics have explanatory power for several correlates of patent scope, including patent maintenance payments, forward citations, and the breadth of patent classes. Narrower claims at publication are generally associated with a higher probability of grant and a shorter examination process[3].

Implications for Innovation

The scope of the patent can influence innovation in the field. Overly broad patents can lead to increased licensing and litigation costs, potentially diminishing incentives for further innovation. Conversely, well-defined and narrower claims can facilitate clearer boundaries, encouraging more targeted research and development[3].

Patent Landscape

Related Patents and Applications

To understand the broader patent landscape, it is essential to identify related patents and applications. Tools like the USPTO's Patent Public Search and the Common Citation Document (CCD) can help in this regard. The CCD consolidates prior art cited by multiple offices, providing a comprehensive view of the patent family and related applications[1].

Global Dossier and International Filings

The Global Dossier service allows users to access file histories of related applications from participating IP Offices. This can reveal how the patent has been treated in different jurisdictions, including any office actions or citations. For patents like US 6,002,008, which may have international filings under the Patent Cooperation Treaty (PCT), this service is particularly useful[1].

Search and Analysis Tools

USPTO Resources

The USPTO offers several resources for searching and analyzing patents, including the Patent Public Search tool, which replaced legacy tools like PubEast and PubWest. This tool provides modern interfaces for enhanced access to prior art. Additionally, the Public Search Facility and Patent and Trademark Resource Centers (PTRCs) offer further assistance in conducting thorough patent searches[1].

Sequence Listings and Mega Items

For patents involving chemical or biological sequences, resources like the Publication Site for Issued and Published Sequences (PSIPS) are invaluable. This site provides access to sequence listings, tables, and other mega items associated with the patent[1].

Ownership and Maintenance

Patent Assignment and Ownership

Understanding the ownership history of a patent is crucial for determining its current status and any potential licensing or acquisition opportunities. The Patent Assignment Search website can be used to track changes in ownership and assignments related to the patent[1].

Maintenance Fees and Status

Patents require the payment of maintenance fees to remain in force. The payment history and current status of these fees can be critical in assessing the patent's validity and enforceability. For US 6,002,008, checking the payment records and any notices related to maintenance fees is essential[2][4].

Key Takeaways

• Claims Analysis: The scope of the patent is defined by its claims, with independent claims setting the broad scope and dependent claims providing specific limitations.
• Patent Scope Metrics: Metrics like independent claim length and count can help in measuring the patent's scope and its implications for innovation.
• Patent Landscape: Tools like the USPTO's Patent Public Search and Global Dossier are essential for understanding the broader patent landscape and related applications.
• Search and Analysis Tools: Utilizing resources from the USPTO, such as the Patent Public Search tool and PSIPS, is crucial for thorough patent analysis.
• Ownership and Maintenance: Tracking ownership changes and maintenance fees is vital for understanding the patent's current status and validity.

FAQs

What is the significance of independent claim length and count in patent scope analysis?

Independent claim length and count are metrics used to measure patent scope. They have explanatory power for several correlates of patent scope, including patent maintenance payments, forward citations, and the breadth of patent classes. Narrower claims are often associated with a higher probability of grant and a shorter examination process[3].

How can I search for related patents and applications using USPTO resources?

You can use the USPTO's Patent Public Search tool and the Global Dossier service to search for related patents and applications. These tools provide enhanced access to prior art and file histories of related applications from participating IP Offices[1].

What is the importance of maintaining patent fees?

Maintaining patent fees is crucial for keeping the patent in force. Failure to pay these fees can result in the patent lapsing or becoming invalid. Checking the payment history and current status of these fees is essential for assessing the patent's validity and enforceability[2][4].

How do I access sequence listings and mega items for a patent?

You can access sequence listings and mega items through the Publication Site for Issued and Published Sequences (PSIPS) website. This site provides these items for granted US patents or published US patent applications[1].

What tools are available for analyzing the ownership history of a patent?

The Patent Assignment Search website and resources from the USPTO's Public Search Facility and PTRCs can be used to track changes in ownership and assignments related to the patent[1].

Sources

1. USPTO: Search for patents - USPTO. Retrieved from https://www.uspto.gov/patents/search
2. Canadian Patents Database: Patent 2964162 Summary. Retrieved from https://www.ic.gc.ca/opic-cipo/cpd/eng/patent/2964162/summary.html
3. SSRN: Patent Claims and Patent Scope. Retrieved from https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2844964
4. Canadian Patents Database: Patent 2613053 Summary. Retrieved from https://www.ic.gc.ca/opic-cipo/cpd/eng/patent/2613053/summary.html
5. PubChem: Substituted 3-cyano quinolines - Patent US-6002008-A. Retrieved from https://pubchem.ncbi.nlm.nih.gov/patent/US-6002008-A

Drugs Protected by US Patent 6,002,008

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate