Details for Patent: 6,191,148

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Summary for Patent: 6,191,148

Title:	Omerazole process and compositions thereof
Abstract:	The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.
Inventor(s):	McManus; James W. (Albany, GA), Anousis; Nick (Albany, GA), Banks; Benjamin Newton (Albany, GA), Liu; Hui (Greenbrook, NJ), Zhou; Lingwen (North Brunswick, NJ)
Assignee:	Merck & Co., Inc. (Rahway, NJ)
Application Number:	09/461,605
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,191,148
Patent Claim Types: see list of patent claims	Compound; Composition;

Drugs Protected by US Patent 6,191,148

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