Details for Patent: 6,222,025

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Summary for Patent: 6,222,025

Patent landscape, scope, and claims:

Title:	Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom
Abstract:	Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
Inventor(s):	Cook; Phillip Dan (Escondido, CA), Sanghvi; Yogesh S. (Encinitas, CA), Sprankle; Kelly G. (Vista, CA), Ross; Bruce S. (Carlsbad, CA), Griffey; Rich H. (Vista, CA), Springer; Robert H. (Carlsbad, CA)
Assignee:	Isis Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:	08/894,899
Patent Claim Types: see list of patent claims	Compound;
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Drugs Protected by US Patent 6,222,025

Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

Foreign Priority and PCT Information for Patent: 6,222,025

PCT Information
PCT Filed	March 06, 1996	PCT Application Number:	PCT/US96/03174
PCT Publication Date:	September 12, 1996	PCT Publication Number:	WO96/27606

International Family Members for US Patent 6,222,025

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	327244	⤷ Subscribe
Australia	5359496	⤷ Subscribe
Canada	2214535	⤷ Subscribe
Germany	69636160	⤷ Subscribe
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