Details for Patent: 6,222,025
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Summary for Patent: 6,222,025
Title: | Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom |
Abstract: | Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid. |
Inventor(s): | Cook; Phillip Dan (Escondido, CA), Sanghvi; Yogesh S. (Encinitas, CA), Sprankle; Kelly G. (Vista, CA), Ross; Bruce S. (Carlsbad, CA), Griffey; Rich H. (Vista, CA), Springer; Robert H. (Carlsbad, CA) |
Assignee: | Isis Pharmaceuticals, Inc. (Carlsbad, CA) |
Application Number: | 08/894,899 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 6,222,025
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>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 6,222,025
PCT Information | |||
PCT Filed | March 06, 1996 | PCT Application Number: | PCT/US96/03174 |
PCT Publication Date: | September 12, 1996 | PCT Publication Number: | WO96/27606 |
International Family Members for US Patent 6,222,025
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Austria | 327244 | ⤷ Sign Up | |||
Australia | 5359496 | ⤷ Sign Up | |||
Canada | 2214535 | ⤷ Sign Up | |||
Germany | 69636160 | ⤷ Sign Up | |||
European Patent Office | 0813539 | ⤷ Sign Up | |||
Japan | 2001097994 | ⤷ Sign Up | |||
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