Details for Patent: 6,395,767
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Summary for Patent: 6,395,767
Title: | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
Abstract: | Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula ##STR1## where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent. |
Inventor(s): | Robl; Jeffrey A. (Newtown, PA), Sulsky; Richard B. (West Trenton, NJ), Augeri; David J. (Princeton, NJ), Magnin; David R. (Hamilton, NJ), Hamann; Lawrence G. (Cherry Hill, NJ), Betebenner; David A. (Lawrenceville, NJ) |
Assignee: | Bristol-Myers Squibb Company (Princeton, NJ) |
Application Number: | 09/788,173 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 6,395,767 |
Patent Claim Types: see list of patent claims | Compound; Composition; Use; | More… ↓ |
Drugs Protected by US Patent 6,395,767
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International Family Members for US Patent 6,395,767
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European Patent Office | 1261586 | ⤷ Subscribe | C300436 | Netherlands | ⤷ Subscribe |
European Patent Office | 1261586 | ⤷ Subscribe | CA 2010 00007 | Denmark | ⤷ Subscribe |
European Patent Office | 1261586 | ⤷ Subscribe | 91650 | Luxembourg | ⤷ Subscribe |
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