Details for Patent: 6,406,713

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Summary for Patent: 6,406,713

Title:	Methods of preparing low-toxicity drug-lipid complexes
Abstract:	Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Inventor(s):	Janoff; Andrew S. (Yardley, PA), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA)
Assignee:	The Liposome Company, Inc. (Princeton, NJ)
Application Number:	08/430,661
Patent Claim Types: see list of patent claims	Use; Formulation; Dosage form;

Drugs Protected by US Patent 6,406,713

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