Details for Patent: 6,451,991

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Summary for Patent: 6,451,991

Title:	Sugar-modified gapped oligonucleotides
Abstract:	Oligonucleotides are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary nucleic acid strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleosides that activate RNase H. Such oligonucleotides are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to ooligonucleotide therapeutics.
Inventor(s):	Martin; Pierre (Rheinfelden, CH), Altmann; Karl-Heinz (Reinach, CH), Cook; Phillip Dan (Vista, CA), Monia; Brett P. (Carlsbad, CA)
Assignee:	ISIS Pharmaceuticals, Inc. (Carlsbad, CA) Novartis AG (CH)
Application Number:	08/802,331
Patent Claim Types: see list of patent claims	Compound;

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