Details for Patent: 6,468,967

Summary for Patent: 6,468,967

Title:	Methods for administration of antibiotics
Abstract:	The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that does not result in muscle toxicity.
Inventor(s):	Oleson, Jr.; Frederick B. (Concord, MA), Tally; Francis P. (Lincoln, MA)
Assignee:	Cubist Pharmaceuticals, Incorporated (Lexington, MA)
Application Number:	09/406,568
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,468,967
Patent Claim Types: see list of patent claims	Use;

Drugs Protected by US Patent 6,468,967

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 6,468,967

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	1115417		91254	Luxembourg
European Patent Office	1115417		CA 2006 00018	Denmark
European Patent Office	1115417		300232	Netherlands
European Patent Office	1115417		06C0022	France
European Patent Office	1115417		SPC 018/2006	Ireland