Details for Patent: 6,562,861

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Summary for Patent: 6,562,861

Title:	Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
Abstract:	##STR1## Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkyl; R4 is (CH2)nOH, (CH2)nNH2, substituted alkyl were prepd. as neuraminidase inhibitors. Thus, (1R,3R,4R,1'S)-(-)-(1'-acetylamino-2 '-ethyl)butyl-4-(aminoimino)methylaminocyclopentan-1-carboxylic acid was prepd. and tested in vitro as neuraminidase inhibitor (IC50<1.mu.M).
Inventor(s):	Babu; Yarlagadda S. (Birmingham, AL), Chand; Pooran (Birmingham, AL), Montgomery; John A. (Birmingham, AL)
Assignee:	BioCryst Pharmaceuticals, Inc. (Birmingham, AL)
Application Number:	09/555,131
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

Drugs Protected by US Patent 6,562,861

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Foreign Priority and PCT Information for Patent: 6,562,861

PCT Information
PCT Filed	December 17, 1998	PCT Application Number:	PCT/US98/26871
PCT Publication Date:	July 08, 1999	PCT Publication Number:	WO99/33781

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