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Last Updated: December 23, 2024

Details for Patent: 6,605,599


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Summary for Patent: 6,605,599
Title: Epothilone derivatives
Abstract:The present invention relates to epothilone derivatives, having the following formula ##STR1## in which the variables G, W, Q, X, Y, B.sub.1, B.sub.2, Z.sub.1, Z.sub.2, and R.sub.1 -R.sub.7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
Inventor(s): Vite; Gregory D. (Titusville, NJ), Kim; Soong-Hoon (Lawrenceville, NJ), Borzilleri; Robert M. (Lawrenceville, NJ), Johnson; James A. (Lawrenceville, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:09/084,542
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;
Patent landscape, scope, and claims:

Understanding the Scope and Claims of United States Patent 6,605,599: A Detailed Analysis

Introduction

United States Patent 6,605,599, titled "Epothilone derivatives," is a significant patent in the pharmaceutical field, particularly in the area of cancer treatment. This patent, issued to various inventors, outlines a series of epothilone derivatives, their preparation methods, and their utility. Here, we will delve into the scope and claims of this patent, as well as the broader patent landscape it inhabits.

Background on Epothilones

Epothilones are a class of macrolide compounds known for their anti-cancer properties. They work by stabilizing microtubules, thereby inhibiting cell division and leading to cell death, particularly in cancer cells. The patent in question focuses on derivatives of these compounds, which are designed to enhance their therapeutic efficacy and reduce side effects[4].

Patent Scope and Claims

Claim Structure

The patent claims are structured to define the scope of the invention clearly. Here are some key aspects:

  • Independent Claims: The patent includes several independent claims that define the core of the invention. These claims are crucial as they set the boundaries of what is considered novel and non-obvious[5].
  • Claim Language: The claims are detailed and specify the chemical structures of the epothilone derivatives. For example, the claims define variables such as G, W, X, Y, Z1, and Z2, which are selected from various groups of chemical moieties. This specificity is essential to ensure that the claims are not overly broad and are supported by the disclosure in the specification[5].

Claim Scope

  • Chemical Formulas: The patent provides detailed chemical formulas for the epothilone derivatives. For instance, the formula includes variables such as G (selected from alkyl, substituted alkyl, aryl, etc.), W (O or NR15), X (O or H), and Y (selected from a group including O, H, OR16, etc.). This level of detail helps in defining the exact scope of the invention[4].
  • Exclusions: The patent also specifies what is excluded from the scope. For example, it excludes compounds where W and X are both O, and other specific combinations of R groups and Z groups[4].

Importance of Claim Scope

The scope of the claims is critical because it determines the breadth of protection the patent offers. A common misconception is that broader claims are always better, but this is not the case. Broader claims can be more difficult to get granted and are easier to invalidate. The key is to balance the scope to ensure it is supported by the disclosure and not overly broad[5].

Patent Landscape

Prior Art and Novelty

  • Prior Art Search: Conducting a thorough prior art search is essential to ensure the novelty of the invention. Tools like the USPTO's Patent Public Search, Global Dossier, and international patent databases (such as those provided by the European Patent Office, Japan Patent Office, and World Intellectual Property Organization) can be used to identify existing patents and published applications that may affect the novelty of the claimed invention[1].
  • Novelty and Non-Obviousness: The claims must be novel and non-obvious over the prior art. The patent office examines the claims against existing patents and publications to ensure they meet these criteria.

International Patent Landscape

  • Global Dossier: The Global Dossier service allows users to view the file histories of related applications from participating IP Offices, including the IP5 Offices. This can help in understanding how similar inventions have been treated in other jurisdictions[1].
  • International Patent Databases: Databases like PATENTSCOPE by WIPO and esp@cenet by the EPO provide access to international patent applications and granted patents, which can be crucial in assessing the global patent landscape for epothilone derivatives[1].

Metrics for Measuring Patent Scope

Research has shown that metrics such as independent claim length and independent claim count can be useful in measuring patent scope. These metrics can help in understanding the breadth of the claims and their potential impact on patent quality and the examination process[3].

Risks of Overly Broad Claims

  • Invalidation Grounds: Overly broad claims can be at risk of being invalidated on grounds such as the abstract idea exception or failure to meet the written description requirement. Recent court decisions have highlighted these risks, emphasizing the importance of carefully crafting claim scope[5].
  • Litigation and Licensing: Broad claims can also lead to increased litigation and licensing costs, which can diminish the incentives for innovation[3].

Practical Considerations

  • Client’s Budget: The claim scope must be considered in the context of the client’s budget. Broader claims may require more extensive prior art searches and can be more costly to prosecute[5].
  • Technical Field: The level of prior art in the technical field is another critical factor. In fields with extensive prior art, broader claims are more likely to be rejected or invalidated[5].

Key Takeaways

  • Balanced Claim Scope: The claim scope should be balanced to ensure it is supported by the disclosure and not overly broad.
  • Thorough Prior Art Search: Conducting a thorough prior art search is essential to ensure the novelty and non-obviousness of the claimed invention.
  • International Considerations: Understanding the global patent landscape is crucial for assessing the scope and potential of the patent.
  • Metrics for Patent Scope: Metrics such as independent claim length and count can help in evaluating the breadth and impact of the claims.

FAQs

What are epothilone derivatives, and why are they important?

Epothilone derivatives are a class of macrolide compounds with anti-cancer properties. They are important because they stabilize microtubules, inhibiting cell division and leading to cell death, particularly in cancer cells.

How do you determine the right claim scope for a patent?

The right claim scope depends on several factors, including the actual invention, the level of prior art, the client’s budget, and the technical field. It should be balanced to ensure it is supported by the disclosure and not overly broad.

What are the risks of having overly broad claims in a patent?

Overly broad claims can be more difficult to get granted, easier to invalidate, and may lead to increased litigation and licensing costs.

How can you measure the scope of a patent?

Metrics such as independent claim length and independent claim count can be used to measure the scope of a patent and understand its potential impact.

What resources can you use to conduct a thorough prior art search for a patent?

Resources include the USPTO's Patent Public Search, Global Dossier, and international patent databases such as those provided by the European Patent Office, Japan Patent Office, and World Intellectual Property Organization.

Sources

  1. USPTO: Search for patents - USPTO. Retrieved from https://www.uspto.gov/patents/search
  2. Google Patents: KR101413955B1 - Aziridinyl-epothilone compounds. Retrieved from https://patents.google.com/patent/KR101413955B1/en
  3. SSRN: Patent Claims and Patent Scope. Retrieved from https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2844964
  4. Google Patents: US6605599B1 - Epothilone derivatives. Retrieved from https://patents.google.com/patent/US6605599B1/en
  5. Rimon Law: The Importance of Getting the Claim Scope Right in a US Patent Application. Retrieved from https://www.rimonlaw.com/the-importance-of-getting-the-claim-scope-right-in-a-us-patent-application-i/

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Drugs Protected by US Patent 6,605,599

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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