Details for Patent: 6,607,748

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Summary for Patent: 6,607,748

Title:	Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
Abstract:	The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.
Inventor(s):	Lenaerts; Vincent (Montreal (Quebec), CA), Beck; Roland Herwig Friedrich (Valparaiso, IN), Van Bogaert; Elsie (B-2880 Bornem, BE), Chouinard; Francois (Lorriane (Quebec), CA), Hopcke; Reiner (D-47533 Kleve, DE), Desevaux; Cyril (Saint-Hubert (Quebec), CA)
Assignee:
Application Number:	09/606,399
Patent Claim Types: see list of patent claims	Composition; Compound; Dosage form; Process; Use;

Drugs Protected by US Patent 6,607,748

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