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Last Updated: December 22, 2024

Details for Patent: 6,749,868


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Summary for Patent: 6,749,868
Title: Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
Abstract:In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.
Inventor(s): Desai; Neil P. (Los Angeles, CA), Tao; Chunlin (Beverly Hills, CA), Yang; Andrew (Rosemead, CA), Louie; Leslie (Montebello, CA), Yao; Zhiwen (Culver City, CA), Soon-Shiong; Patrick (Los Angeles, CA), Magdassi; Shlomo (Jerusalem, IL)
Assignee: American BioScience, Inc. (Santa Monica, CA)
Application Number:09/316,642
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,749,868
Patent Claim Types:
see list of patent claims
Delivery;
Patent landscape, scope, and claims:

Understanding the Scope and Claims of United States Patent 6,749,868

Introduction

United States Patent 6,749,868, titled "Drag Delivery System," is a patent that describes a specific method and system for delivering pharmacologically active agents. To analyze this patent, it is crucial to delve into its scope, claims, and the broader patent landscape in which it resides.

Patent Overview

The patent in question pertains to a drag delivery system where part of the molecules of a pharmacologically active agent are bound to a drag agent. This system is designed to enhance the delivery and efficacy of the active agent.

Claims Analysis

Independent Claims

The independent claims of the patent define the core invention and are critical for understanding the scope of the patent. These claims typically outline the essential components and steps of the drag delivery system.

  • Claim 1: This claim usually sets out the broadest definition of the invention, including the drag agent, the pharmacologically active agent, and the method of binding these agents.
  • Claim 2 and Subsequent Claims: These claims often narrow down the invention by specifying particular aspects, such as the type of drag agent, the method of binding, or specific applications of the delivery system.

Dependent Claims

Dependent claims build upon the independent claims and provide additional details or limitations. These claims help in defining the invention more precisely and can be crucial in distinguishing the invention from prior art.

Scope of the Patent

The scope of the patent is determined by the claims, particularly the independent claims. It is essential to understand what is covered and what is not.

  • Coverage: The patent covers a drag delivery system where the pharmacologically active agent is bound to a drag agent, enhancing delivery and efficacy.
  • Exclusions: Any variations or alternatives not explicitly covered by the claims are outside the scope of the patent.

Patent Landscape Analysis

To fully understand the position of this patent within the broader landscape, a comprehensive patent landscape analysis is necessary.

Defining Scope and Keywords

Identify the relevant technology field and specific keywords related to drag delivery systems and pharmacologically active agents. This step helps in narrowing down the search to relevant patents[3].

Searching and Organizing Patents

Use patent databases such as the USPTO's Patent Public Search tool, Global Dossier, or international databases like the European Patent Office's esp@cenet to find relevant patents. Organize these patents by factors such as filing date, assignee, and technology subcategories[4].

Identifying Trends and Key Players

Analyze the patterns in patent filings to identify significant contributors and trends in the field. This helps in understanding the competitive landscape and potential legal vulnerabilities[3].

Analyzing Citations and Evolution

Study how patents reference each other to understand their impact and development. Tools like the Common Citation Document (CCD) can consolidate prior art cited by multiple offices, providing a clearer picture of the patent's position within the landscape[4].

Insights from Patent Landscape Analysis

A thorough analysis provides several key insights:

  • Technological Trends: Understanding current innovations and future directions in drag delivery systems and related technologies.
  • Key Players: Identifying major players in the field, including their patent portfolios and areas of focus.
  • Legal Vulnerabilities: Recognizing potential legal issues or vulnerabilities in the patent, such as prior art or overlapping claims.
  • Strategic Decisions: Translating analysis outcomes into practical guidance for strategic choices, such as whether to pursue further research, licensing, or litigation[3].

Real-World Applications and Practical Utility

To ensure the patent remains relevant and enforceable, it is crucial to highlight real-world applications and practical utility. For example:

  • Improved Efficacy: Demonstrating how the drag delivery system enhances the efficacy of pharmacologically active agents in specific medical conditions.
  • Clinical Benefits: Showing how the system provides tangible benefits, such as improved patient outcomes or reduced side effects[1].

Recent Developments and Guidance

While the patent in question may not directly involve AI or software-related technologies, recent updates in patent guidance can still offer valuable insights.

  • USPTO Guidance on AI and Software Patents: The 2024 USPTO guidance update on AI and software patents emphasizes the importance of integrating judicial exceptions into practical applications. Although this guidance is not directly applicable, it underscores the need for any patent to demonstrate concrete technological improvements and practical utility[1].

Key Takeaways

  • Claims Analysis: The scope of the patent is defined by its claims, with independent claims setting the broadest definition and dependent claims providing additional details.
  • Patent Landscape: A comprehensive analysis helps in understanding technological trends, key players, and legal vulnerabilities.
  • Practical Utility: Highlighting real-world applications and practical benefits is crucial for maintaining the patent's relevance and enforceability.
  • Strategic Insights: The analysis provides actionable insights for strategic decisions regarding the patent.

FAQs

  1. What is the main focus of United States Patent 6,749,868?

    • The main focus is on a drag delivery system where part of the molecules of a pharmacologically active agent are bound to a drag agent.
  2. How do you conduct a patent landscape analysis for this patent?

    • Define the scope and keywords, search and organize relevant patents, identify trends and key players, analyze citations and evolution, and generate insights for strategic decisions.
  3. What are the key elements to consider when analyzing the claims of this patent?

    • Independent claims define the core invention, while dependent claims provide additional details. The scope of the patent is determined by these claims.
  4. How does recent USPTO guidance on AI and software patents relate to this analysis?

    • While not directly applicable, the guidance emphasizes the importance of demonstrating practical utility and concrete technological improvements, which is relevant for any patent.
  5. What insights can be gained from a patent landscape analysis?

    • Insights include understanding technological trends, identifying key players, recognizing legal vulnerabilities, and generating practical guidance for strategic decisions.

More… ↓

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Drugs Protected by US Patent 6,749,868

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 6,749,868

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0961612 ⤷  Subscribe CA 2009 00036 Denmark ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe 91613 Luxembourg ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe 09C0050 France ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe C00961612/01 Switzerland ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe SZ 41/2009 Austria ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe 441 Finland ⤷  Subscribe
European Patent Office 0961612 ⤷  Subscribe 2009C/046 Belgium ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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