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Last Updated: December 23, 2024

Details for Patent: 6,833,384


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Summary for Patent: 6,833,384
Title: Deacetylase inhibitors
Abstract:The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
Inventor(s): Remiszewski; Stacy William (Washington Township, NJ), Bair; Kenneth Walter (Mountain Lakes, NJ), Versace; Richard William (Wanaque, NJ), Perez; Lawrence Blas (Hackettstown, NJ), Green; Michael Alan (Easton, PA), Sambucetti; Lidia Cristina (Pacifica, CA), Sharma; Sushil (West Orange, NJ)
Assignee: Novartis AG (Basel, CH)
Application Number:10/299,518
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent landscape, scope, and claims:

Understanding the Scope and Claims of United States Patent 6,833,384: A Detailed Analysis

Introduction

United States Patent 6,833,384, titled "Deacetylase inhibitors," is a significant patent that delves into the realm of biochemical research, particularly focusing on the regulation of gene expression through the inhibition of deacetylase enzymes. This article will provide a comprehensive analysis of the patent's scope, claims, and the broader patent landscape it inhabits.

Background: Deacetylase Inhibitors and Gene Expression

Deacetylase inhibitors are compounds that target histone deacetylases (HDACs), enzymes involved in the reversible acetylation of histones. This process is crucial for regulating gene expression by altering the accessibility of transcription factors to DNA[1].

Patent Overview

Publication Details

  • Publication Number: US6833384B2
  • Prior Art Date: The patent builds upon prior research in the field of cancer and tumor treatment, among other areas.
  • Legal Status: Active, with an expiration date based on the patent's filing and grant dates.

Claims Analysis

Claim Structure

The patent includes multiple claims that define the scope of the invention. These claims are categorized into independent and dependent claims.

Independent Claims

Independent claims stand alone and do not refer to any other claims. They define the broadest scope of the invention. For example, Claim 1 might describe a deacetylase inhibitor compound with specific structural features.

Dependent Claims

Dependent claims refer back to and further limit the scope of an independent claim. These claims often describe specific embodiments or variations of the invention, such as particular methods of synthesis or application.

Claim Indefiniteness

Patent claims must provide reasonable certainty in defining what is patented, as mandated by 35 U.S.C. § 112. The claims in US6833384B2 must be precise enough to inform those skilled in the art about the scope of the invention with reasonable certainty, while recognizing that absolute precision is unattainable[2].

Scope of the Invention

Chemical Compounds

The patent describes a range of chemical compounds that act as deacetylase inhibitors. These compounds are characterized by their structural features, including alkyl, aryl, and methyl groups. The scope includes various derivatives and analogs of these compounds.

Therapeutic Applications

The invention encompasses the use of these deacetylase inhibitors in therapeutic applications, particularly in the treatment of cancer and other diseases where histone deacetylation plays a critical role.

Methods of Synthesis

The patent also covers methods for synthesizing these compounds, providing detailed procedures and reagents involved in their production.

Patent Landscape

Prior Art and Related Patents

The patent landscape for deacetylase inhibitors is extensive, with numerous prior art references and related patents. These patents often focus on different aspects of HDAC inhibition, such as specific compound structures, synthesis methods, or therapeutic applications.

Competing Patents

Other patents in the field may claim similar or overlapping subject matter, necessitating a careful analysis of the claims and specifications to distinguish the unique contributions of US6833384B2.

Economic and Research Implications

Patent Claims Research Dataset

The USPTO's Patent Claims Research Dataset provides insights into the trends and measurements of patent scope, including those related to biochemical patents like US6833384B2. This dataset can help researchers and practitioners understand the broader context and impact of such patents[3].

Market Impact

Deacetylase inhibitors have significant market potential, particularly in the pharmaceutical industry. The patent's scope and claims can influence the development and commercialization of these compounds, affecting both research and therapeutic outcomes.

Legal Considerations

Claim Construction and Indefiniteness

The construction of patent claims is a critical legal issue. Courts must ensure that claims are not indefinite, as this can lead to invalidation. The decision in cases like Nautilus, Inc. v. Biosig Instruments, Inc. emphasizes the need for claims to be precise enough to afford clear notice of what is claimed[2].

Patent Litigation

Patent litigation often revolves around the interpretation and validity of claims. For US6833384B2, any disputes over claim scope or infringement would need to be resolved through legal proceedings, where the court would construe the claims in light of the specification and prosecution history.

Expert Insights and Statistics

Industry Expert Views

Experts in the field of biochemical research and patent law highlight the importance of precise claim drafting to avoid indefiniteness and ensure the patent's validity. For instance, Alan Marco, former Chief Economist for the USPTO, has discussed the importance of clear and concise patent claims in various studies[5].

Statistical Trends

The USPTO's economic research datasets show trends in patent filings and grants in the biochemical sector. These statistics can provide insights into the competitive landscape and the impact of patents like US6833384B2 on innovation and industry development[3].

Key Takeaways

  • Precise Claim Drafting: The patent's claims must be precise and clear to avoid indefiniteness.
  • Therapeutic Applications: The invention has significant therapeutic potential, particularly in cancer treatment.
  • Market Impact: The patent influences the development and commercialization of deacetylase inhibitors.
  • Legal Considerations: Claim construction and indefiniteness are critical legal issues that can affect the patent's validity.

FAQs

What is the primary focus of United States Patent 6,833,384?

The primary focus of US6833384B2 is on deacetylase inhibitors, specifically their structure, synthesis, and therapeutic applications.

How do deacetylase inhibitors regulate gene expression?

Deacetylase inhibitors regulate gene expression by preventing the deacetylation of histones, thereby altering the accessibility of transcription factors to DNA.

What are the therapeutic applications of the compounds described in the patent?

The compounds are primarily used in the treatment of cancer and other diseases where histone deacetylation plays a critical role.

How important is claim precision in patent law?

Claim precision is crucial to avoid indefiniteness and ensure the patent's validity, as mandated by 35 U.S.C. § 112.

What resources are available for analyzing patent claims and scope?

Resources such as the USPTO's Patent Claims Research Dataset and legal precedents like Nautilus, Inc. v. Biosig Instruments, Inc. are invaluable for analyzing patent claims and scope.

Sources

  1. US6833384B2 - Deacetylase inhibitors - Google Patents
  2. UNITED STATES COURT OF APPEALS FOR THE FEDERAL CIRCUIT - Nature Simulation Systems Inc. v. Autodesk, Inc.
  3. Patent Claims Research Dataset - USPTO
  4. Search for patents - USPTO
  5. U.S. Patent Small Claims Court - ACUS

More… ↓

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Drugs Protected by US Patent 6,833,384

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 6,833,384

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1318980 ⤷  Subscribe CA 2015 00068 Denmark ⤷  Subscribe
European Patent Office 1318980 ⤷  Subscribe 92890 Luxembourg ⤷  Subscribe
European Patent Office 1318980 ⤷  Subscribe 15C0086 France ⤷  Subscribe
European Patent Office 1318980 ⤷  Subscribe 300778 Netherlands ⤷  Subscribe
European Patent Office 1318980 ⤷  Subscribe 1590070-7 Sweden ⤷  Subscribe
European Patent Office 1318980 ⤷  Subscribe 122015000098 Germany ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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