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Last Updated: December 27, 2024

Details for Patent: 6,939,964


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Summary for Patent: 6,939,964
Title: Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one
Abstract:The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40.degree. C. and 50.degree. C.
Inventor(s): Crocker; Louis S. (Belle Mead, NJ), Kukura, II; Joseph L. (Somerset, NJ), Thompson; Andrew S. (Mountainside, NJ), Stelmach; Christine (Westfield, NJ), Young; Steven D. (Lansdale, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:10/891,749
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,939,964
Patent Claim Types:
see list of patent claims
Compound;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 6,939,964

Introduction

United States Patent 6,939,964, titled "Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one," is a patent that describes a method for crystallizing a specific compound. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Patent Overview

Publication and Authority

The patent, numbered US6939964B2, was published by the United States Patent and Trademark Office (USPTO) and is categorized under the authority of the US patent system[4].

Prior Art and Keywords

The patent includes prior art keywords such as "solvent," "slurry," "water," "cyclopropylethynyl," and "benzoxazin," indicating the chemical and procedural context of the invention[4].

Legal Status

As of the current date, the patent has expired, marking the end of its lifetime and the public domain status of the described methods and compounds[4].

Claims Analysis

Claim Structure

The claims in a patent are crucial as they define the scope of the invention. For US6939964B2, the claims would typically include a combination of independent and dependent claims. Independent claims stand alone and define the broadest scope of the invention, while dependent claims narrow down the scope by adding additional limitations to the independent claims[2].

Claim Construction

Claim construction is a critical legal process that determines the meaning and scope of the claims. This process is a question of law and is reviewed de novo on appeal. The claims must inform those skilled in the art with reasonable certainty, ensuring that the scope of the invention is clear and not indefinite[2].

Scope of the Invention

Method of Crystallization

The patent describes a method for crystallizing a specific compound, (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one. This method involves using specific solvents and conditions to achieve the desired crystal form, which is crucial for the compound's stability and efficacy[4].

Chemical Context

The invention is rooted in organic chemistry, particularly in the synthesis and crystallization of complex organic compounds. The scope includes the use of various solvents and conditions to achieve the crystallization, which is a key aspect of pharmaceutical and chemical research[4].

Patent Landscape

Related Patents and Applications

To understand the broader patent landscape, one would need to look at related patents and applications, particularly those within the same patent family or those that cite this patent. Tools like the Global Dossier and the Common Citation Document (CCD) can be used to identify related applications and prior art cited by different patent offices[1].

Industry Impact

Patents like US6939964B2 are significant in the pharmaceutical and chemical industries, where the crystallization of compounds is a critical step in drug development. The expiration of this patent means that the methods described are now in the public domain, potentially allowing other companies to use these methods without infringing on the original patent[4].

Search and Research Tools

USPTO Resources

The USPTO provides several resources for searching and analyzing patents, including the Public Search Facility, Patent and Trademark Resource Centers (PTRCs), and online databases like the Patent Official Gazette and the Publication Site for Issued and Published Sequences (PSIPS)[1].

Global Dossier and CCD

The Global Dossier and the Common Citation Document (CCD) are essential tools for analyzing the global patent landscape. These tools provide access to file histories, patent families, and citation data, helping to identify the scope and impact of a patent on a global scale[1].

Economic and Legal Considerations

Patent Validity and Infringement

Patents are accompanied by a presumption of validity, but they can be challenged through inter partes review (IPR) or other legal proceedings. The validity of claims and the potential for infringement are critical legal considerations that can significantly impact the commercial use of patented inventions[2].

Small Claims Patent Court

There have been discussions and studies on the feasibility of a small claims patent court, which could simplify and reduce the costs associated with patent litigation. This could have implications for the enforcement and defense of patents like US6939964B2, especially for smaller entities[5].

Key Takeaways

  • Patent Scope: The patent describes a specific method for crystallizing a compound, which is now in the public domain.
  • Claims Analysis: Claims must be clear and not indefinite, and their construction is a legal process reviewed de novo.
  • Patent Landscape: Understanding related patents and applications is crucial for navigating the broader patent landscape.
  • Industry Impact: The expiration of the patent allows other companies to use the described methods without infringement.
  • Search Tools: Utilizing USPTO resources, Global Dossier, and CCD is essential for comprehensive patent analysis.

FAQs

What is the current legal status of US6939964B2?

The patent has expired, meaning the described methods and compounds are now in the public domain.

How are claims in a patent constructed and reviewed?

Claim construction is a legal process that determines the meaning and scope of the claims, reviewed de novo on appeal to ensure clarity and non-indefiniteness[2].

What tools can be used to analyze the global patent landscape?

Tools like the Global Dossier and the Common Citation Document (CCD) provide access to file histories, patent families, and citation data, helping to identify the scope and impact of a patent globally[1].

Why is the crystallization method described in US6939964B2 important?

The crystallization method is crucial for the stability and efficacy of the compound, which is significant in pharmaceutical and chemical research[4].

What are the implications of a small claims patent court?

A small claims patent court could simplify and reduce the costs associated with patent litigation, particularly beneficial for smaller entities[5].

Sources

  1. USPTO: Search for patents - USPTO.
  2. CAFC: VASCULAR SOLUTIONS LLC v. MEDTRONIC, INC.
  3. USPTO: Patent Claims Research Dataset.
  4. Google Patents: US6939964B2 - Crystal forms of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one.
  5. ACUS: U.S. Patent Small Claims Court.

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Drugs Protected by US Patent 6,939,964

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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