Details for Patent: 7,015,315

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Summary for Patent: 7,015,315

Title:	Gapped oligonucleotides
Abstract:	Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.
Inventor(s):	Cook; Phillip Dan (Vista, CA), Monia; Brett P. (Carlsbad, CA)
Assignee:	ISIS Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:	08/465,866
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 7,015,315

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