Details for Patent: 7,108,866

Summary for Patent: 7,108,866

Title:	Chronotherapeutic diltiazem formulations and the administration thereof
Abstract:	A controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 120 mg to about 540 mg or more (as desired) of the form of Diltiazem associated with excipients to provide controlled (sustained) release of the form of Diltiazem for providing a C.sub.max of Diltiazem in the blood at between about 10 hours and about 15 hours after administration, the preparation comprising the form of Diltiazem in oral sustained-release dosage form in which the Diltiazem is adapted to be released after administration over a prolonged period of time and exhibits when given to humans(i) a higher bioavailability when given at night compared to when given in the morning without food according to FDA guidelines or criteria and(ii) bioequivalence when given in the morning with and without food according to the same FDA guidelines or criteria.
Inventor(s):	Albert; Kenneth Stephen (Mt. Kisco, NY), Maes; Paul Jose (Oakville, CA)
Assignee:	Biovall Laboratories International SRL (St. Michael, BB)
Application Number:	09/567,451
Patent Claim Types: see list of patent claims	Use; Composition; Dosage form; Formulation;

Drugs Protected by US Patent 7,108,866

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 7,108,866

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Canada	2292247	Dec 10, 1999
Canada	2307547	May 04, 2000

International Family Members for US Patent 7,108,866

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	430561
Australia	4903700
Canada	2292247
Canada	2307547