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Last Updated: December 22, 2024

Details for Patent: 7,378,423


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Which drugs does patent 7,378,423 protect, and when does it expire?

Patent 7,378,423 protects MEKINIST and is included in two NDAs.

Protection for MEKINIST has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.

This patent has forty-nine patent family members in twenty-eight countries.

Summary for Patent: 7,378,423
Patent landscape, scope, and claims:
Title:Pyrimidine compound and medical use thereof
Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] ##STR00001## wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
Inventor(s): Kawasaki; Hisashi (Osaka, JP), Abe; Hiroyuki (Osaka, JP), Hayakawa; Kazuhide (Osaka, JP), Iida; Tetsuya (Osaka, JP), Kikuchi; Shinichi (Osaka, JP), Yamaguchi; Takayuki (Osaka, JP), Nanayama; Toyomichi (Osaka, JP), Kurachi; Hironori (Osaka, JP), Tamaru; Masahiro (Osaka, JP), Hori; Yoshikazu (Osaka, JP), Takahashi; Mitsuru (Osaka, JP), Yoshida; Takayuki (Yokohama, JP), Sakai; Toshiyuki (Kyoto, JP)
Assignee: Japan Tobacco Inc. (Tokyo, JP)
Application Number:11/150,792
Patent Claim Types:
see list of patent claims
Compound; Composition;

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Drugs Protected by US Patent 7,378,423

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Novartis MEKINIST trametinib dimethyl sulfoxide SOLUTION;ORAL 217513-001 Mar 16, 2023 RX Yes Yes ⤷  Subscribe ⤷  Subscribe Y ⤷  Subscribe
Novartis MEKINIST trametinib dimethyl sulfoxide TABLET;ORAL 204114-001 May 29, 2013 RX Yes No ⤷  Subscribe ⤷  Subscribe Y ⤷  Subscribe
Novartis MEKINIST trametinib dimethyl sulfoxide TABLET;ORAL 204114-002 May 29, 2013 DISCN Yes No ⤷  Subscribe ⤷  Subscribe Y ⤷  Subscribe
Novartis MEKINIST trametinib dimethyl sulfoxide TABLET;ORAL 204114-003 May 29, 2013 RX Yes Yes ⤷  Subscribe ⤷  Subscribe Y ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 7,378,423

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan2004-174770Jun 11, 2004
Japan2004-327111Nov 10, 2004

International Family Members for US Patent 7,378,423

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1761528 ⤷  Subscribe C300701 Netherlands ⤷  Subscribe
European Patent Office 1761528 ⤷  Subscribe PA2014039 Lithuania ⤷  Subscribe
European Patent Office 1761528 ⤷  Subscribe CA 2014 00055 Denmark ⤷  Subscribe
European Patent Office 1761528 ⤷  Subscribe 14C0083 France ⤷  Subscribe
European Patent Office 1761528 ⤷  Subscribe C20140036 00120 Estonia ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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