Details for Patent: 7,427,638
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Which drugs does patent 7,427,638 protect, and when does it expire?
Patent 7,427,638 protects OTEZLA and is included in one NDA.
Protection for OTEZLA has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.
This patent has eighty patent family members in twenty-three countries.
Summary for Patent: 7,427,638
| Title: | (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminois- oindoline-1,3-dione:, and methods of synthesis and compositions thereof |
| Abstract: | Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoin- doline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4. |
| Inventor(s): | Muller; George W. (Bridgewater, NJ), Schafer; Peter H. (Somerset, NJ), Man; Hon-Wah (Princeton, NJ), Ge; Chuansheng (Belle Mead, NJ) |
| Assignee: | Celgene Corporation (Summit, NJ) |
| Application Number: | 11/106,142 |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 7,427,638 |
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Patent Claim Types: see list of patent claims | Composition; Compound; Dosage form; |
Drugs Protected by US Patent 7,427,638
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amgen Inc | OTEZLA | apremilast | TABLET;ORAL | 205437-001 | Mar 21, 2014 | AB | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | Y | ⤷ Sign Up | |||
| Amgen Inc | OTEZLA | apremilast | TABLET;ORAL | 205437-002 | Mar 21, 2014 | AB | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | Y | ⤷ Sign Up | |||
| Amgen Inc | OTEZLA | apremilast | TABLET;ORAL | 205437-003 | Mar 21, 2014 | AB | RX | Yes | Yes | ⤷ Sign Up | ⤷ Sign Up | Y | ⤷ Sign Up | |||
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 7,427,638
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 2962690 | ⤷ Sign Up | 300994 | Netherlands | ⤷ Sign Up |
| European Patent Office | 2962690 | ⤷ Sign Up | LUC00125 | Luxembourg | ⤷ Sign Up |
| European Patent Office | 2962690 | ⤷ Sign Up | 122019000070 | Germany | ⤷ Sign Up |
| European Patent Office | 2962690 | ⤷ Sign Up | CA 2019 00033 | Denmark | ⤷ Sign Up |
| European Patent Office | 2962690 | ⤷ Sign Up | 2019C/008 | Belgium | ⤷ Sign Up |
| European Patent Office | 2962690 | ⤷ Sign Up | 37/2019 | Austria | ⤷ Sign Up |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
