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Last Updated: November 8, 2024

Details for Patent: 7,427,638


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Which drugs does patent 7,427,638 protect, and when does it expire?

Patent 7,427,638 protects OTEZLA and is included in one NDA.

Protection for OTEZLA has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.

This patent has eighty patent family members in twenty-three countries.

Summary for Patent: 7,427,638
Title:(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminois- oindoline-1,3-dione:, and methods of synthesis and compositions thereof
Abstract: Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoin- doline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4.
Inventor(s): Muller; George W. (Bridgewater, NJ), Schafer; Peter H. (Somerset, NJ), Man; Hon-Wah (Princeton, NJ), Ge; Chuansheng (Belle Mead, NJ)
Assignee: Celgene Corporation (Summit, NJ)
Application Number:11/106,142
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,427,638
Patent Claim Types:
see list of patent claims
Composition; Compound; Dosage form;

Drugs Protected by US Patent 7,427,638

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Amgen Inc OTEZLA apremilast TABLET;ORAL 205437-001 Mar 21, 2014 AB RX Yes No ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Amgen Inc OTEZLA apremilast TABLET;ORAL 205437-002 Mar 21, 2014 AB RX Yes No ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
Amgen Inc OTEZLA apremilast TABLET;ORAL 205437-003 Mar 21, 2014 AB RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y ⤷  Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 7,427,638

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 2962690 ⤷  Sign Up 300994 Netherlands ⤷  Sign Up
European Patent Office 2962690 ⤷  Sign Up LUC00125 Luxembourg ⤷  Sign Up
European Patent Office 2962690 ⤷  Sign Up 122019000070 Germany ⤷  Sign Up
European Patent Office 2962690 ⤷  Sign Up CA 2019 00033 Denmark ⤷  Sign Up
European Patent Office 2962690 ⤷  Sign Up 2019C/008 Belgium ⤷  Sign Up
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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