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Last Updated: December 22, 2024

Details for Patent: 7,462,625


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Summary for Patent: 7,462,625
Title:Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ##STR00001## wherein A, Q, R.sub.1, R.sub.2, R.sub.3a, R.sub.3b, R.sub.4, R.sub.5, R.sub.6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
Inventor(s): Zhu; Yun-Fei (San Diego, CA), Chen; Chen (San Diego, CA), Tucci; Fabio C. (San Diego, CA), Guo; Zhiqiang (San Diego, CA), Gross; Timothy D. (San Diego, CA), Rowbottom; Martin (La Jolla, CA), Struthers; R. Scott (Encinitas, CA)
Assignee: Neurocrine Biosciences, Inc. (San Diego, CA)
Application Number:11/520,022
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

United States Patent 7,462,625: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 7,462,625, titled "GnRH receptor antagonists," is a significant patent in the field of pharmaceuticals, particularly in the treatment of sex-hormone related conditions. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background of the Patent

The patent, granted to inventors for their work on Gonadotropin-releasing hormone (GnRH) receptor antagonists, is aimed at treating various sex-hormone related conditions in both men and women. GnRH receptors play a crucial role in the regulation of the reproductive system, and antagonists of these receptors can be used to manage conditions such as prostate cancer, endometriosis, and precocious puberty[2][5].

Scope of the Patent

The scope of US Patent 7,462,625 encompasses the design, synthesis, and use of specific GnRH receptor antagonists. Here are the key aspects:

Chemical Compounds

The patent describes a series of chemical compounds that act as GnRH receptor antagonists. These compounds are detailed in terms of their structural formulas, synthesis methods, and pharmacological activities[2][5].

Therapeutic Applications

The patent outlines the therapeutic applications of these antagonists, including the treatment of conditions such as prostate cancer, endometriosis, and other sex-hormone related disorders. The scope also includes methods for administering these compounds and their dosages.

Pharmaceutical Formulations

The patent covers various pharmaceutical formulations of the GnRH receptor antagonists, including but not limited to tablets, capsules, and injectable solutions. This ensures that the compounds can be delivered effectively to patients[2].

Claims of the Patent

The claims of a patent are its most critical component, as they define the legal boundaries of the invention. Here are some key claims of US Patent 7,462,625:

Independent Claims

  • The patent includes independent claims that describe the specific chemical structures of the GnRH receptor antagonists.
  • Claims related to the methods of synthesizing these compounds.
  • Claims covering the therapeutic uses of these antagonists, including specific conditions and methods of treatment[2].

Dependent Claims

  • Dependent claims further specify the scope of the independent claims, such as particular dosages, administration routes, and pharmaceutical formulations.

Patent Landscape Analysis

To understand the significance and positioning of US Patent 7,462,625 within the broader patent landscape, several factors need to be considered:

Competitor Patents

Other patents in the field of GnRH receptor antagonists need to be analyzed to identify overlapping claims and potential infringement issues. This involves searching through databases such as the USPTO's Patent Public Search tool, the European Patent Office's esp@cenet, and other international patent databases[1].

Claim Coverage Matrix

A Claim Coverage Matrix can be used to categorize and analyze the claims of US Patent 7,462,625 alongside other related patents. This matrix helps in identifying which patents and claims are actively protecting the intellectual property and where gaps or opportunities exist[3].

Scope Concepts

Categorizing patents by scope concepts, rather than just claims, provides a more comprehensive view of the patent landscape. This approach helps in filtering, searching, and analyzing large numbers of patent claims concurrently, making it easier to determine the value and applicability of the patent claims[3].

Global Patent Trends

The global patent landscape for GnRH receptor antagonists is dynamic, with various countries and organizations actively involved in research and development. Here are some key trends:

International Patenting Activity

The USPTO data indicates that while the United States, Japan, and the European Union dominate the patent landscape, other countries like South Korea, China, and India are increasingly active in patenting activities related to pharmaceuticals and biotechnology[4].

Cross-National Comparisons

Cross-national comparisons reveal that multinational firms often choose patent locations based on factors such as tax policies and intellectual property protection. This can influence the global distribution of patents related to GnRH receptor antagonists[4].

Tools and Resources for Analysis

Several tools and resources are available for analyzing the patent landscape and claims of US Patent 7,462,625:

USPTO Resources

  • The USPTO's Patent Public Search tool and the Global Dossier service provide comprehensive access to prior art and related patent applications.
  • The Patent and Trademark Resource Centers (PTRCs) offer training and resources for conducting thorough patent searches[1].

Patent Analytics Software

  • Software like ClaimScape® by Schwegman can generate interactive claim charts to help review patent coverage and identify gaps or opportunities in the current claim set[3].

Key Takeaways

  • Scope and Claims: US Patent 7,462,625 covers specific GnRH receptor antagonists, their synthesis, and therapeutic applications.
  • Patent Landscape: The patent is part of a broader landscape that includes competitor patents, global trends, and cross-national comparisons.
  • Tools and Resources: Utilizing tools like the USPTO's Patent Public Search and patent analytics software is crucial for a thorough analysis.
  • Global Trends: The patent landscape is influenced by international patenting activities, tax policies, and intellectual property protection.

FAQs

Q: What is the primary focus of US Patent 7,462,625?

A: The primary focus is on GnRH receptor antagonists for treating sex-hormone related conditions.

Q: How can one analyze the claims of this patent in relation to other patents?

A: Using a Claim Coverage Matrix and categorizing patents by scope concepts can help in analyzing and comparing claims.

Q: What resources are available for searching and analyzing patents related to this invention?

A: Resources include the USPTO's Patent Public Search tool, Global Dossier, and patent analytics software like ClaimScape®.

Q: How does international patenting activity impact the landscape of GnRH receptor antagonists?

A: International patenting activity, influenced by factors like tax policies and IP protection, affects the global distribution and development of related patents.

Q: What is the significance of the USPTO's Global Dossier service in patent analysis?

A: The Global Dossier service provides access to file histories of related applications from participating IP Offices, helping in identifying office actions and related applications globally[1].

Sources

  1. USPTO: Search for patents - USPTO.
  2. Unified Patents Portal: US-7462625-B2 - Unified Patents Portal.
  3. SLWIP: Patent Analytics | Intellectual Property Law.
  4. NSF: Chapter 8 - Invention, Knowledge Transfer, and Innovation.
  5. PubChem: Gonadotropin-releasing hormone receptor antagonists and methods ...

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Drugs Protected by US Patent 7,462,625

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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