Details for Patent: 8,101,663

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Summary for Patent: 8,101,663

Patent landscape, scope, and claims:

Title:	Polymorphs of suberoylanilide hydroxamic acid
Abstract:	The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.
Inventor(s):	Miller; Thomas A. (Brookline, MA), Richon; Victoria M. (Wellesley, MA)
Assignee:	Merck HDAC Research, LLC (Boston, MA)
Application Number:	12/653,073
Patent Claim Types: see list of patent claims	Use; Composition; Formulation;
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Drugs Protected by US Patent 8,101,663

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

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Australia	2003213684	⤷ Subscribe
Australia	2004266169	⤷ Subscribe
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