Details for Patent: 8,628,754

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Summary for Patent: 8,628,754

Title:	Highly efficient delivery of a large therapeutic mass aerosol
Abstract:	A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm.sup.3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles. Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm.sup.3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
Inventor(s):	Edwards; David A. (Cambridge, MA), Batycky; Richard P. (Newton, MA), Johnston; Lloyd (Newton, MA)
Assignee:	Civitas Therapeutics, Inc. (Chelsea, MA)
Application Number:	13/334,236
Patent Claim Types: see list of patent claims	Use; Delivery;

Drugs Protected by US Patent 8,628,754

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