Details for Patent: 9,439,985
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Which drugs does patent 9,439,985 protect, and when does it expire?
Patent 9,439,985 protects LYMPHOSEEK KIT and is included in one NDA.
This patent has twenty patent family members in eight countries.
Summary for Patent: 9,439,985
Title: | Compositions for radiolabeling diethylenetriaminepentaacetic acid (DTPA)-dextran |
Abstract: | The subject invention relates to the compositions for radiolabeling Diethylenetriaminepentaacetic Acid (DTPA)-dextran with Technetium-99m and for stabilizing the DTPA-dextran Cold Kit. The composition contains Stannous Chloride ions to reduce .sup.99mTc-pertechnetate, Ascorbic Acid to reduce stannic ions to stannous ions to maintain a reducing environment, .alpha.,.alpha.-Trehalose to add bulk and to stabilize the lyophilized composition without interfering with the radiochemical yield, and Glycine to transchelate Technetium-99m under highly acidic conditions to facilitate radiolabeling DTPA-dextran with high radiochemical purity. In addition, the invention pertains to methods for making and using the compositions. The reconstitution of the lyophilized composition by .sup.99mTc-pertechnetate, resulting in radiolabeled .sup.99mTc-DTPA-dextran in a composition between pH 3 to 4. This invention contains a Diluent vial, which when used will shift the pH to a moderately acidic pH, which would provide less pain on injection and ease-of-use to clinical practioners for adjusting its potency. |
Inventor(s): | Magneson; Gerald Ross (Powell, OH), Orahood; Richard Cushman (Delaware, OH) |
Assignee: | Navidea Biopharmaceuticals, Inc. (Dublin, OH) |
Application Number: | 14/039,648 |
Patent Claim Types: see list of patent claims | Composition; Compound; |
Drugs Protected by US Patent 9,439,985
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cardinal Health 414 | LYMPHOSEEK KIT | technetium tc-99m tilmanocept | INJECTABLE;INJECTION | 202207-001 | Mar 13, 2013 | RX | Yes | Yes | ⤷ Sign Up | ⤷ Sign Up | Y | ⤷ Sign Up | ||||
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 9,439,985
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
Australia | 2010208624 | ⤷ Sign Up | |||
Brazil | PI1007487 | ⤷ Sign Up | |||
Canada | 2750230 | ⤷ Sign Up | |||
China | 102301429 | ⤷ Sign Up | |||
European Patent Office | 2392012 | ⤷ Sign Up | |||
European Patent Office | 3884965 | ⤷ Sign Up | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |