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Last Updated: December 23, 2024

Details for Patent: 9,566,276


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Which drugs does patent 9,566,276 protect, and when does it expire?

Patent 9,566,276 protects LYNPARZA and is included in one NDA.

This patent has eighty-five patent family members in thirty-seven countries.

Summary for Patent: 9,566,276
Title:Phthalazinone derivatives
Abstract: Compounds of the formula (I): ##STR00001## wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or CR.sup.XR.sup.Y; if X.dbd.NR.sup.X then n is 1 or 2 and if X.dbd.CR.sup.XR.sup.Y then n is 1; R.sup.X is selected from the group consisting of H, optionally substituted C.sub.1-20 alkyl, C.sub.5-20 aryl, C.sub.3-20heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R.sup.Y is selected from H, hydroxy, amino; or R.sup.X and R.sup.Y may together form a spiro-C.sub.3-7 cycloalkyl or heterocyclyl group; R.sup.C1and R.sup.C2 are both hydrogen, or when X is CR.sup.XR.sup.Y, R.sup.C1, R.sup.C2, R.sup.X and R.sup.Y, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R.sup.1 is selected from H and halo.
Inventor(s): Martin; Niall Morrison Barr (Cambridge, GB), Smith; Graeme Cameron (Cambridge, GB), Jackson; Stephen Philip (Cambridge, GB), Loh; Vincent Junior M (Horsham, GB), Cockcroft; Xiao-Ling Fan (Horsham, GB), Matthews; Ian Timothy Williams (Horsham, GB), Menear; Keith Allan (Horsham, GB), Kerrigan; Frank (Cornwall, GB), Ashworth; Alan (London, GB)
Assignee: KUDOS PHARMACEUTICALS LIMITED (Cambridge, Cambridgeshire, GB)
Application Number:14/853,360
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

United States Patent 9,566,276: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

The United States Patent 9,566,276, titled "Phthalazinone derivatives," is a patent that covers a specific class of chemical compounds and their applications, particularly in the field of medicine. This analysis will delve into the scope and claims of the patent, as well as the broader patent landscape in which it resides.

Scope of the Patent

The patent focuses on phthalazinone derivatives, which are a class of compounds with potential therapeutic applications. These compounds are described in detail, including their chemical structures, synthesis methods, and biological activities.

Chemical Structure and Synthesis

The patent describes various phthalazinone derivatives, detailing their chemical formulas, functional groups, and the processes for synthesizing these compounds. Key chemical groups mentioned include alkyl, aryl, hydroxy, and carbamoylamino groups[1].

Biological Activities

The compounds are evaluated for their biological activities, particularly their cytotoxic effects and potential as antineoplastic agents. The patent includes data on the compounds' efficacy in cell lines, including those lacking BRCA2 function, which is significant in the context of cancer research[1].

Claims of the Patent

The patent claims are crucial as they define the scope of protection granted to the inventors.

Independent Claims

The independent claims cover the phthalazinone derivatives themselves, their methods of preparation, and their use in therapeutic applications. These claims are broad enough to encompass a range of compounds but specific enough to distinguish them from prior art[1].

Dependent Claims

Dependent claims further narrow down the scope by specifying particular functional groups, substitution patterns, and biological activities. These claims provide additional protection for specific embodiments of the invention[1].

Patent Landscape Analysis

Understanding the patent landscape is essential for navigating the technological and competitive environment.

Competitor Analysis

Patent landscape analysis reveals the competitive landscape in the field of phthalazinone derivatives. It identifies other patents and pending applications related to similar compounds, helping to understand the market position and potential risks or opportunities[3].

Legal Status and Expiry Dates

The legal status of the patent, including whether it is alive, pending, lapsed, revoked, or expired, is critical. For US9566276B2, the patent has expired, which affects its current legal standing and the freedom to operate in this technological domain[3].

Global Patent Family

Using tools like the Global Dossier, one can identify the patent family for this specific application, including related applications filed at participating IP Offices. This helps in understanding the global reach and protection of the invention[4].

Market Developments and Trends

Patent landscape studies also reveal market trends and developments such as mergers and acquisitions, in/out-licensing, and litigation activities. These insights are crucial for strategic decision-making and minimizing business risks[3].

Mergers and Acquisitions

The patent landscape can indicate whether there have been any mergers or acquisitions involving companies holding related patents, which could impact the competitive landscape.

Licensing and Litigation

Understanding licensing agreements and any ongoing litigation related to these compounds can provide valuable insights into the commercial viability and legal challenges associated with these inventions.

Technical Insights

The patent landscape analysis provides technical insights into the development of phthalazinone derivatives.

Synthesis Methods

Advanced synthesis methods and any improvements over existing techniques are highlighted, which can be crucial for commercial production and cost optimization.

Biological Efficacy

The analysis includes data on the biological efficacy of these compounds, which is essential for understanding their therapeutic potential and any regulatory hurdles they might face.

Business and Strategic Implications

The insights from the patent landscape analysis have significant business and strategic implications.

Risk Mitigation

Understanding the patent landscape helps in identifying potential risks such as patent infringement, litigation, and regulatory challenges. This allows for better risk mitigation strategies.

Opportunity Identification

The analysis can also identify opportunities such as licensing, collaborations, and new market entries. This is particularly important for companies looking to expand their portfolio in the pharmaceutical sector.

Conclusion

The United States Patent 9,566,276 on phthalazinone derivatives is a significant patent in the field of medicinal chemistry. Understanding its scope, claims, and the broader patent landscape is crucial for any entity operating in this domain. The expired status of the patent means that the protected compounds are now in the public domain, but the insights gained from the patent landscape analysis remain valuable for future research and development.

Key Takeaways

  • Scope and Claims: The patent covers phthalazinone derivatives, their synthesis, and therapeutic applications.
  • Patent Landscape: The analysis reveals competitor activity, market trends, and technical insights.
  • Legal Status: The patent has expired, affecting its current legal standing.
  • Business Implications: Understanding the patent landscape is crucial for risk mitigation and opportunity identification.

FAQs

What are phthalazinone derivatives?

Phthalazinone derivatives are a class of chemical compounds with potential therapeutic applications, particularly in cancer treatment.

What is the significance of the BRCA2 function in the patent?

The patent includes data on the efficacy of phthalazinone derivatives in cell lines lacking BRCA2 function, which is significant in the context of cancer research.

Why is patent landscape analysis important?

Patent landscape analysis provides valuable insights into competitors, market trends, and technical developments, which are essential for strategic decision-making.

What are the implications of the patent's expired status?

The expired status means that the protected compounds are now in the public domain, but the insights from the patent landscape analysis remain valuable for future research and development.

How can companies use the insights from this patent landscape analysis?

Companies can use these insights to mitigate risks, identify opportunities such as licensing or collaborations, and inform their research and development strategies.

Cited Sources

  1. US9566276B2 - Phthalazinone derivatives - Google Patents
  2. Determining Inventorship for US Patent Applications
  3. Navigating Technological Domains with Patent Landscape Analysis
  4. Search for patents - USPTO
  5. Intellectual Property Protection - KU Office of Research

More… ↓

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Drugs Protected by US Patent 9,566,276

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Astrazeneca LYNPARZA olaparib TABLET;ORAL 208558-001 Aug 17, 2017 RX Yes No ⤷  Subscribe ⤷  Subscribe MAINTENANCE TREATMENT OF DELETERIOUS OR SUSPECTED DELETERIOUS GBRCA-MUTATED METASTATIC PANCREATIC ADENOCARCINOMA WHOSE DISEASE HAS NOT PROGRESSED ON AT LEAST 16 WEEKS OF A FIRST-LINE PLATINUM-BASED CHEMOTHERAPY REGIMEN ⤷  Subscribe
Astrazeneca LYNPARZA olaparib TABLET;ORAL 208558-002 Aug 17, 2017 RX Yes Yes ⤷  Subscribe ⤷  Subscribe MAINTENANCE TREATMENT OF DELETERIOUS OR SUSPECTED DELETERIOUS GBRCA-MUTATED METASTATIC PANCREATIC ADENOCARCINOMA WHOSE DISEASE HAS NOT PROGRESSED ON AT LEAST 16 WEEKS OF A FIRST-LINE PLATINUM-BASED CHEMOTHERAPY REGIMEN ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 9,566,276

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom0305681.9Mar 12, 2003

International Family Members for US Patent 9,566,276

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1633724 ⤷  Subscribe C300726 Netherlands ⤷  Subscribe
European Patent Office 1633724 ⤷  Subscribe CR 2015 00012 Denmark ⤷  Subscribe
European Patent Office 1633724 ⤷  Subscribe C20150012 00136 Estonia ⤷  Subscribe
European Patent Office 1633724 ⤷  Subscribe 92680 Luxembourg ⤷  Subscribe
European Patent Office 1633724 ⤷  Subscribe PA2015016 Lithuania ⤷  Subscribe
European Patent Office 1633724 ⤷  Subscribe 15C0022 France ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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