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Last Updated: November 2, 2024

Details for Patent: 9,796,741


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Summary for Patent: 9,796,741
Title:Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders
Abstract:Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein Ror Ron the A group is an aryl, heteroaryl or heterocycle (R) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.
Inventor(s):Gadhachanda Venkat Rao, Wang Qiuping, Pais Godwin, Hashimoto Akihiro, Chen Dawei, Wang Xiangzhu, Agarwal Atul, Deshpande Milind, Wiles Jason Allan, Phadke Avinash S.
Assignee:Achillion Pharmaceuticals, Inc.
Application Number:US14631625
Patent Claim Types:
see list of patent claims
 

Drugs Protected by US Patent 9,796,741

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Alexion Pharms Inc VOYDEYA danicopan TABLET;ORAL 218037-001 Mar 29, 2024 RX Yes No ⤷  Sign Up ⤷  Sign Up Y TREATMENT OF EXTRAVASCULAR HEMOLYSIS (EVH) IN ADULTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) AS ADD-ON THERAPY TO RAVULIZUMAB OR ECULIZUMAB ⤷  Sign Up
Alexion Pharms Inc VOYDEYA danicopan TABLET;ORAL 218037-002 Mar 29, 2024 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y TREATMENT OF EXTRAVASCULAR HEMOLYSIS (EVH) IN ADULTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) AS ADD-ON THERAPY TO RAVULIZUMAB OR ECULIZUMAB ⤷  Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 9,796,741

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2015223068 ⤷  Sign Up
Australia 2015223072 ⤷  Sign Up
Australia 2015223075 ⤷  Sign Up
Australia 2015223084 ⤷  Sign Up
Australia 2015223121 ⤷  Sign Up
Australia 2015223132 ⤷  Sign Up
Australia 2020260434 ⤷  Sign Up
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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