UPNEEQ Drug Patent Profile

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Which patents cover Upneeq, and when can generic versions of Upneeq launch?

Upneeq is a drug marketed by Rvl Pharms and is included in one NDA. There are twelve patents protecting this drug.

This drug has fifty-one patent family members in twenty-eight countries.

The generic ingredient in UPNEEQ is oxymetazoline hydrochloride. There are three drug master file entries for this compound. Four suppliers are listed for this compound. Additional details are available on the oxymetazoline hydrochloride profile page.

DrugPatentWatch^® Generic Entry Outlook for Upneeq

Indicators of Generic Entry

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Summary for UPNEEQ

International Patents:	51
US Patents:	12
Applicants:	1
NDAs:	1
Finished Product Suppliers / Packagers:	1
Raw Ingredient (Bulk) Api Vendors:	69
Clinical Trials:	2
Patent Applications:	1,937
What excipients (inactive ingredients) are in UPNEEQ?	UPNEEQ excipients list
DailyMed Link:	UPNEEQ at DailyMed

Drug patent expirations by year for UPNEEQ

Recent Clinical Trials for UPNEEQ

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
Milton S. Hershey Medical Center	Phase 3
University of Miami	Phase 4

See all UPNEEQ clinical trials

Pharmacology for UPNEEQ

Drug Class	Vasoconstrictor
Physiological Effect	Increased Sympathetic Activity Vasoconstriction

US Patents and Regulatory Information for UPNEEQ

UPNEEQ is protected by twelve US patents.

Patents protecting UPNEEQ

Compositions and methods for treating ocular disorders
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Oxymetazoline compositions
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Patent Expiration: ⤷ Sign Up

Compositions and methods for non-surgical treatment of ptosis
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Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Compositions and methods for treating ocular disorders
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Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up

Oxymetazoline compositions
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Compositions and methods for treating ocular disorders
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up

Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Compositions and methods for non-surgical treatment of ptosis
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Patent Expiration: ⤷ Sign Up
Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

Compositions and methods for non-surgical treatment of Ptosis
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Patented Use: METHOD OF TREATING BLEPHAROPTOSIS

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Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Rvl Pharms	UPNEEQ	oxymetazoline hydrochloride	SOLUTION/DROPS;OPHTHALMIC	212520-001	Jul 8, 2020		RX	Yes	Yes	⤷ Sign Up	⤷ Sign Up				⤷ Sign Up
Rvl Pharms	UPNEEQ	oxymetazoline hydrochloride	SOLUTION/DROPS;OPHTHALMIC	212520-001	Jul 8, 2020		RX	Yes	Yes	⤷ Sign Up	⤷ Sign Up				⤷ Sign Up
Rvl Pharms	UPNEEQ	oxymetazoline hydrochloride	SOLUTION/DROPS;OPHTHALMIC	212520-001	Jul 8, 2020		RX	Yes	Yes	⤷ Sign Up	⤷ Sign Up				⤷ Sign Up
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Exclusivity Expiration

International Patents for UPNEEQ

When does loss-of-exclusivity occur for UPNEEQ?

Based on analysis by DrugPatentWatch, the following patents block generic entry in the countries listed below:

Australia

Patent: 20268329
Patent: Oxymetazoline compositions and methods for treating ocular disorders
Estimated Expiration: ⤷ Sign Up

Brazil

Patent: 2021022404
Patent: Composições de oximetazolina e métodos para tratamento de distúrbios oculares
Estimated Expiration: ⤷ Sign Up

Canada

Patent: 39443
Patent: COMPOSITIONS D'OXYMETAZOLINE ET PROCEDES DE TRAITEMENT DE TROUBLES OCULAIRES (OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OCULAR DISORDERS)
Estimated Expiration: ⤷ Sign Up

Chile

Patent: 21002918
Patent: Composiciones y métodos de oximetazolina para el tratamiento de trastornos oculares
Estimated Expiration: ⤷ Sign Up

China

Patent: 1888326
Patent: 羟甲唑啉组合物和用于治疗眼障碍的方法 (Compositions and methods for treating ocular disorders)
Estimated Expiration: ⤷ Sign Up

Patent: 7045596
Patent: 羟甲唑啉组合物和用于治疗眼障碍的方法 (Oxymetazoline compositions and methods for treating ocular disorders)
Estimated Expiration: ⤷ Sign Up

Colombia

Patent: 21015265
Patent: Composiciones y métodos de oximetazolina para el tratamiento de trastornos oculares
Estimated Expiration: ⤷ Sign Up

European Patent Office

Patent: 65737
Patent: COMPOSITIONS D'OXYMÉTAZOLINE ET PROCÉDÉS DE TRAITEMENT DE TROUBLES OCULAIRES (OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OCULAR DISORDERS)
Estimated Expiration: ⤷ Sign Up

Israel

Patent: 7831
Patent: תרכובות אוקסימטזולין ושיטות לטיפול במחלות עיניים (Oxymetazoline compositions and methods for treating ocular disorders)
Estimated Expiration: ⤷ Sign Up

Japan

Patent: 41420
Estimated Expiration: ⤷ Sign Up

Patent: 20183373
Patent: 眼疾患を処置するためのオキシメタゾリン組成物および方法 (OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES)
Estimated Expiration: ⤷ Sign Up

Patent: 21191802
Patent: 眼疾患を処置するためのオキシメタゾリン組成物および方法 (OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES)
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Mexico

Patent: 21013516
Patent: COMPOSICIONES Y MÉTODOS DE OXIMETAZOLINA PARA EL TRATAMIENTO DE TRASTORNOS OCULARES. (OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OCULAR DISORDERS.)
Estimated Expiration: ⤷ Sign Up

Morocco

Patent: 895
Patent: COMPOSITIONS D'OXYMÉTAZOLINE ET PROCÉDÉS DE TRAITEMENT DE TROUBLES OCULAIRES
Estimated Expiration: ⤷ Sign Up

Peru

Patent: 220384
Patent: COMPOSICIONES Y METODOS DE OXIMETAZOLINA PARA EL TRATAMIENTO DE TRASTORNOS OCULARES
Estimated Expiration: ⤷ Sign Up

Singapore

Patent: 202112272T
Patent: OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OCULAR DISORDERS
Estimated Expiration: ⤷ Sign Up

South Africa

Patent: 2108950
Patent: OXYMETAZOLINE COMPOSITIONS AND METHODS FOR TREATING OCULAR DISORDERS
Estimated Expiration: ⤷ Sign Up

South Korea

Patent: 2410503
Estimated Expiration: ⤷ Sign Up

Patent: 200128629
Patent: 안구 장애를 치료하기 위한 옥시메타졸린 조성물 및 방법 (Oxymetazoline Compositions and Methods for Treating Ocular Disorders)
Estimated Expiration: ⤷ Sign Up

Patent: 220084264
Patent: 안구 장애를 치료하기 위한 옥시메타졸린 조성물 및 방법 (Oxymetazoline Compositions and Methods for Treating Ocular Disorders)
Estimated Expiration: ⤷ Sign Up

Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.

See the table below for additional patents covering UPNEEQ around the world.

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Country	Patent Number	Title	Estimated Expiration
Lithuania	2680829		⤷ Sign Up
World Intellectual Property Organization (WIPO)	2012118704		⤷ Sign Up
South Korea	20240060580	안구 장애를 치료하기 위한 옥시메타졸린 조성물 및 방법 (Oxymetazoline Compositions and Methods for Treating Ocular Disorders)	⤷ Sign Up
>Country	>Patent Number	>Title	>Estimated Expiration

Indicators of Generic Entry

AI Research Assistant

Questions you can ask:

Summary for UPNEEQ

Recent Clinical Trials for UPNEEQ

Pharmacology for UPNEEQ

Patents protecting UPNEEQ

When does loss-of-exclusivity occur for UPNEEQ?

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