Collagenase - Biologic Drug Details

Summary for collagenase

Tradenames:	1
High Confidence Patents:	3
Applicants:	3
BLAs:	3
Suppliers: see list	2
Recent Clinical Trials:	See clinical trials for collagenase
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for collagenase

Recent Clinical Trials for collagenase

Identify potential brand extensions & biosimilar entrants

Sponsor	Phase
Mayo Clinic	N/A
Endo Pharmceuticals	Phase 3
Foundation for Orthopaedic Research and Education	Phase 3

See all collagenase clinical trials

Recent Litigation for collagenase

Identify key patents and potential future biosimilar entrants

District Court Litigation

Case Name	Date
Apple Inc. v. ITC	2023-12-26
SoftWave Tissue Regeneration Technologies, LLC v. Dr. Har Hari S. Khalsa, DC	2022-10-26
Apple Inc. v. Masimo Corporation	2022-10-20

See all collagenase litigation

PTAB Litigation

Petitioner	Date
	2020-01-28
	2018-07-17
Avita Medical Limited	2017-04-04

See all collagenase litigation

Pharmacology for collagenase

Ingredient-type	Collagenases
Established Pharmacologic Class	Collagen-specific Enzyme

Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

1. Brand-side disclosures in response to biosimilar applications

These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

2. General brand-side disclosures

These patents were identified from searching drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

3. Patents from broad patent text search

For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for collagenase Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for collagenase Derived from Company Disclosures

These patents were obtained from company disclosures

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2039-03-29	Company disclosures
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2026-01-30	Company disclosures
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2039-02-26	Company disclosures

3) Low Certainty: US Patents for collagenase Derived from Patent Text Search

These patents were obtained by searching patent claims

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2032-12-28	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2039-02-26	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2031-02-04	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2031-09-30	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2030-06-07	Patent claims search

Market Dynamics and Financial Trajectory for Collagenase

Introduction to Collagenase

Collagenase is an enzyme that catalyzes the hydrolysis of collagen, a primary structural protein in connective tissues. This enzyme is crucial in various medical, research, and industrial applications, including cosmetic procedures, treatment of fibrotic diseases, and tissue engineering.

Market Size and Growth

The global collagenase market was valued at $0.9 billion in 2023 and is projected to reach $1.2 billion by 2033, growing at a Compound Annual Growth Rate (CAGR) of 3% from 2024 to 2033[1].

Drivers of Market Growth

Increasing Research Activities

The surge in research activities across scientific and medical fields significantly drives the collagenase market. The enzyme's versatility in breaking down collagen makes it a valuable tool in various research applications, contributing to its growing demand[1].

Rising Cosmetic Procedures

The increasing number of cosmetic surgeries and aesthetic procedures also boosts the demand for collagenase. According to the American Society of Plastic Surgeons (ASPS), there was a notable increase in cosmetic surgeries in 2023, indicating a growing market potential for collagenase-based products[1].

Treatment of Fibrotic Diseases

Collagenase, particularly collagenase clostridium histolyticum, is used to treat conditions like Dupuytren's contracture and Peyronie's disease. The growing prevalence of these conditions, exacerbated by factors such as diabetes and smoking, drives the market for this specific type of collagenase[2].

Restraints and Challenges

High Production Costs

The production of collagenase involves complex and expensive processes, including microbial fermentation, purification, and quality control. These high costs, combined with stringent regulatory requirements, make collagenase an expensive reagent, which can limit its market penetration[1].

Competitive Pricing

Alternative enzymes and reagents often offer competitive pricing, which can divert potential users away from collagenase. This competition in the market can restrain the growth of the collagenase market[1].

Market Segmentation

By Type

The collagenase market is bifurcated into bacterial collagenase and animal collagenase. Each type has its specific applications and user bases, influencing market dynamics differently[1].

By Application

The market is categorized into medical, research, and industrial applications. The medical segment, particularly treatments for fibrotic diseases, is a significant driver of market growth[1].

By End User

The market is segmented into hospitals and clinics, research laboratories, and pharmaceutical and biotechnology companies. These end-users have different needs and purchasing behaviors, affecting market trends[1].

By Region

The market is analyzed across North America, Europe, Asia-Pacific, and Latin America, Middle East, and Africa (LAMEA). Regions like Asia-Pacific, particularly China and India, present immense potential due to growing disposable incomes and expanding medical tourism[1].

Regional Market Outlook

North America and Europe

These regions are driven by the increasing prevalence of cosmetic procedures and robust healthcare infrastructure. Rising awareness and adoption of advanced enzymatic treatments in Europe also contribute to market growth[1].

Asia-Pacific

This region, especially China and India, offers significant growth opportunities due to growing disposable incomes, changing beauty standards, and expanding medical tourism. The region's large patient population and growing healthcare infrastructure are key drivers[1].

Latin America and Middle East

These emerging markets are characterized by increasing healthcare investments and a growing focus on aesthetic procedures. Government initiatives aimed at improving healthcare access and quality further support market growth in these regions[1].

Competitive Landscape

The collagenase market is dominated by major players such as Thermo Fisher Scientific Inc., Worthington Biochemical Corporation, Merck KGaA (Sigma-Aldrich), Roche Diagnostics, and others. These companies invest heavily in research and development to maintain their market position and expand their product offerings[1].

Financial Trajectory

Current Market Value

The global collagenase market was valued at $0.9 billion in 2023[1].

Projected Market Value

The market is projected to reach $1.2 billion by 2033, with a CAGR of 3% from 2024 to 2033[1].

Revenue Streams

The revenue is generated from various applications, including medical treatments, research activities, and industrial uses. The medical segment, particularly treatments for conditions like Dupuytren's contracture, is expected to contribute significantly to the revenue growth[2][4].

Key Takeaways

• The collagenase market is driven by increasing research activities, rising cosmetic procedures, and the treatment of fibrotic diseases.
• High production costs and competitive pricing from alternative enzymes are significant restraints.
• The market is segmented by type, application, end user, and region, with Asia-Pacific and Latin America showing promising growth.
• Major players dominate the market, with significant investments in R&D.
• The market is projected to grow from $0.9 billion in 2023 to $1.2 billion by 2033.

FAQs

1. What is the current market size of the global collagenase market? The global collagenase market was valued at $0.9 billion in 2023[1].

2. What is the projected growth rate of the collagenase market from 2024 to 2033? The market is expected to grow at a CAGR of 3% from 2024 to 2033[1].

3. Which regions are expected to drive the growth of the collagenase market? North America, Europe, and particularly the Asia-Pacific region are expected to drive market growth due to increasing cosmetic procedures, robust healthcare infrastructure, and growing disposable incomes[1].

4. What are the main applications of collagenase? The main applications include medical treatments (such as for Dupuytren's contracture and Peyronie's disease), research activities, and industrial uses[1][2].

5. Who are the major players in the collagenase market? Major players include Thermo Fisher Scientific Inc., Worthington Biochemical Corporation, Merck KGaA (Sigma-Aldrich), Roche Diagnostics, and others[1].

Sources:

1. Allied Market Research - Collagenase Market Size, Share and Growth Report, 2033[1]
2. IndustryARC - Collagenase Clostridium Histolyticum Market Report, 2024-2030[2]
3. GlobeNewswire - Global Dupuytren's Disease Research Report 2023: A $5.87 Billion Market by 2030[4]
4. OpenPR - Global Collagenase Market Size to Surpass USD 107 Million[5]