Collagenase - Biologic Drug Details

Summary for collagenase

Tradenames:	1
High Confidence Patents:	3
Applicants:	3
BLAs:	3
Suppliers: see list	3
Recent Clinical Trials:	See clinical trials for collagenase
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for collagenase

Recent Clinical Trials for collagenase

Identify potential brand extensions & biosimilar entrants

Sponsor	Phase
Mayo Clinic	N/A
Foundation for Orthopaedic Research and Education	Phase 3
EndoPharmceuticals	Phase 3

See all collagenase clinical trials

Recent Litigation for collagenase

Identify key patents and potential future biosimilar entrants

District Court Litigation

Case Name	Date
Apple Inc. v. ITC	2023-12-26
SoftWave Tissue Regeneration Technologies, LLC v. Dr. Har Hari S. Khalsa, DC	2022-10-26
Apple Inc. v. Masimo Corporation	2022-10-20

See all collagenase litigation

PTAB Litigation

Petitioner	Date
	2020-01-28
	2018-07-17
Avita Medical Limited	2017-04-04

See all collagenase litigation

Pharmacology for collagenase

Ingredient-type	Collagenases
Established Pharmacologic Class	Collagen-specific Enzyme

Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

1. Brand-side disclosures in response to biosimilar applications

These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

2. General brand-side disclosures

These patents were identified from searching drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

3. Patents from broad patent text search

For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for collagenase Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for collagenase Derived from Company Disclosures

These patents were obtained from company disclosures

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2039-03-29	Company disclosures
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2026-01-30	Company disclosures
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338		2039-02-26	Company disclosures

3) Low Certainty: US Patents for collagenase Derived from Patent Text Search

These patents were obtained by searching patent claims

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2032-12-28	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2039-02-26	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2031-02-04	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2031-09-30	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2030-06-07	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2039-02-26	Patent claims search
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995		2030-08-14	Patent claims search