Claims for Patent: 7,923,008

Summary for Patent: 7,923,008

Title:	Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
Abstract:	A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget\'s disease are also provided.
Inventor(s):	Boyle; William J. (Moorpark, CA)
Assignee:	Amgen Inc. (Thousand Oaks, CA)
Application Number:	11/336,067
Patent Claims:	1. A method of decreasing bone resorption comprising selecting a patient having an increase in the rate of bone resorption over the rate of bone formation, and administering to the patient a composition comprising a monoclonal antibody or binding fragment thereof which specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 1 to 317 as shown in FIG. 4 (SEQ ID NO:39) wherein the monoclonal antibody or binding fragment thereof is an antagonist which decreases the activity of osteoprotegerin binding protein. 2. The method of Claim 1 wherein the antibody or binding fragment thereof is a recombinant antibody. 3. The method of claim 1 wherein the antibody or binding fragment thereof is a chimeric antibody or a CDR-grafted antibody. 4. The method of claim 1 wherein the antibody or binding fragment thereof is a human antibody. 5. The method of Claim 4 wherein the antibody or binding fragment thereof is prepared by immunization of a transgenic animal capable of producing human antibodies. 6. The method of Claim 1 wherein the antibody or binding fragment thereof specifically binds to an extracellular domain of an osteoprotegerin binding protein. 7. The method of claim 1 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 69 to 317 as shown in FIG. 4 (SEQ ID NO:39). 8. The method of Claim 1 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 158 to 317 as shown in FIG. 4 (SEQ ID NO:39). 9. The method of Claim 1 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 166 to 317 as shown in FIG. 4 (SEQ ID NO:39). 10. The method of claim 1 wherein the composition comprises a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative and/or adjuvant. 11. The method of claim 10 wherein the diluent is acetate buffer. 12. The method of claim 10 wherein the solubilizer is polysorbate. 13. The method of claim 1 further comprising administering one or more of a bone morphogenic factor, transforming growth factor-.beta., a transforming growth factor-.beta. family member, a fibroblast growth factor, an interleukin-1 inhibitor, a TNF.alpha. inhibitor, parathyroid hormone, an E series prostaglandin, a bisphosphonate, or a bone-enhancing mineral. 14. The method of claim 1 wherein the increase in bone resorption is associated with osteoporosis, osteomyelitis, hypercalcemia, osteopenia brought on by surgery or steroid administration, Paget's disease, osteonecrosis, bone loss due to rheumatoid arthritis, periodontal bone loss, osteopenia due to immobilization, prosthetic loosening or osteolytic metastasis. 15. The method of claim 1 wherein the antibody or binding fragment thereof specifically binds to a membrane associated form of osteoprotegerin binding protein. 16. The method of claim 1 wherein the antibody or binding fragment thereof specifically binds to a soluble osteoprotegerin binding protein. 17. A method of decreasing osteoclast formation comprising selecting a patient having an increase in the rate of bone resorption over the rate of bone formation, and administering to the patient a composition comprising a monoclonal antibody or binding fragment thereof which specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 1 to 317 as shown in FIG. 4 (SEQ ID NO:39), wherein the monoclonal antibody or binding fragment thereof is an antagonist which decreases the activity of osteoprotegerin binding protein. 18. The method of claim 17 wherein the antibody or binding fragment thereof is a recombinant antibody. 19. The method of claim 17 wherein the antibody or binding fragment thereof is a chimeric antibody or a CDR-grafted antibody. 20. The method of claim 17 wherein the antibody or binding fragment thereof is a human antibody. 21. The method of claim 20 wherein the antibody or binding fragment thereof is prepared by immunization of a transgenic animal capable of producing human antibodies. 22. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to an extracellular domain of an osteoprotegerin binding protein. 23. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 69 to 317 as shown in FIG. 4 (SEQ ID NO:39). 24. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 158 to 317 as shown in FIG. 4 (SEQ ID NO:39). 25. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 166 to 317 as shown in FIG. 4 (SEQ ID NO:39). 26. The method of claim 17 wherein the composition comprises a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative and/or adjuvant. 27. The method of claim 17 wherein the diluent is acetate buffer. 28. The method of claim 26 wherein the solubilizer is polysorbate. 29. The method of any of claim 17 further comprising administering one or more of a bone morphogenic factor, transforming growth factor-.beta., a transforming growth factor-.beta. family member, a fibroblast growth factor, an interleukin-1 inhibitor, a TNF.alpha. inhibitor, parathyroid hormone, an E series prostaglandin, a bisphosphonate, or a bone-enhancing mineral. 30. The method of claim 17 wherein the increase in bone resorption is associated with osteoporosis, osteomyelitis, hypercalcemia, osteopenia brought on by surgery or steroid administration, Paget's disease, osteonecrosis, bone loss due to rheumatoid arthritis, periodontal bone loss, osteopenia due to immobilization, prosthetic loosening and osteolytic metastasis. 31. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to a membrane associated form of osteoprotegerin binding protein. 32. The method of claim 17 wherein the antibody or binding fragment thereof specifically binds to a soluble osteoprotegerin binding protein. 33. The method of claim 17 wherein the antibody or binding fragment thereof is raised against an osteoprotegerin binding protein comprising the amino acid sequence as shown in FIG. 4 (SEQ ID NO:39) from residues 1-317, or an immunogenic fragment thereof. 34. The method of claim 17 wherein the antibody or binding fragment thereof is raised against an osteoprotegerin binding protein comprising the amino acid sequence as shown in FIG. 4 (SEQ ID NO:39) from residues 69-317.

Details for Patent 7,923,008

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	PROLIA	denosumab	Injection	125320	June 01, 2010		2017-04-16
Amgen Inc.	XGEVA	denosumab	Injection	125320	November 18, 2010		2017-04-16
Takeda Pharmaceuticals U.s.a., Inc.	NATPARA	parathyroid hormone	For Injection	125511	January 23, 2015		2017-04-16

International Patent Family for US Patent 7,923,008

Country	Patent Number	Estimated Expiration
South Africa	983189
Yugoslavia	50699
World Intellectual Property Organization (WIPO)	9846751
United States of America	7807795
United States of America	7097834
United States of America	6316408