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Last Updated: December 24, 2024

Patent: 5,270,181


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Summary for Patent: 5,270,181
Title: Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
Abstract:This invention provides a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to the DNA sequence encoding a selected heterologous peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of said molecule. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
Inventor(s): McCoy; John (Reading, MA), LaVallie; Edward R. (Tewksbury, MA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Application Number:07/745,382
Patent Claims:see list of patent claims

Details for Patent 5,270,181

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Wyeth Pharmaceuticals Inc. NEUMEGA oprelvekin For Injection 103694 November 25, 1997 5,270,181 2011-02-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 5,270,181

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 9516044 ⤷  Subscribe
World Intellectual Property Organization (WIPO) 9402502 ⤷  Subscribe
World Intellectual Property Organization (WIPO) 9213955 ⤷  Subscribe
United States of America 6143524 ⤷  Subscribe
United States of America 5646016 ⤷  Subscribe
United States of America 5292646 ⤷  Subscribe
Mexico 9203295 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration

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