Patent: 7,374,757

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Summary for Patent: 7,374,757

Title:	Modified chimeric polypeptides with improved pharmacokinetic properties
Abstract:	Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
Inventor(s):	Papadopoulos; Nicholas J. (Lagrangeville, NY), Davis; Samuel (New York, NY), Yancopoulos; George D. (Yorktown Heights, NY)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	11/016,097
Patent Claims:	see list of patent claims

Details for Patent 7,374,757

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	November 18, 2011	⤷ Sign Up	2019-06-08
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	August 16, 2018	⤷ Sign Up	2019-06-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,374,757

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Country	Patent Number	Estimated Expiration
Argentina	044938	⤷ Sign Up
Austria	E293164	⤷ Sign Up
Austria	E417928	⤷ Sign Up
Austria	E427962	⤷ Sign Up
Austria	E486091	⤷ Sign Up
Australia	2004252175	⤷ Sign Up
Australia	2005201365	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration

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