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Last Updated: December 22, 2024

HUMALOG MIX 75/25 Drug Profile


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Summary for Tradename: HUMALOG MIX 75/25
High Confidence Patents:0
Applicants:1
BLAs:1
Recent Clinical Trials: See clinical trials for HUMALOG MIX 75/25
Recent Clinical Trials for HUMALOG MIX 75/25

Identify potential brand extensions & biosimilar entrants

SponsorPhase
Manchester University NHS Foundation TrustN/A
Inreda Diabetic B.V.N/A
Hospital de Especialidades, Centro Medico Nacional "La Raza", Instituto Mexicano del Seguro SocialPhase 4

See all HUMALOG MIX 75/25 clinical trials

Pharmacology for HUMALOG MIX 75/25
Ingredient-typeInsulin
Established Pharmacologic ClassInsulin Analog
Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

  1. Brand-side disclosures in response to biosimilar applications
  2. These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

  3. General brand-side disclosures
  4. These patents were identified from searching drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

  5. Patents from broad patent text search
  6. For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for HUMALOG MIX 75/25 Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for HUMALOG MIX 75/25 Derived from Company Disclosures

No patents found based on company disclosures

3) Low Certainty: US Patents for HUMALOG MIX 75/25 Derived from Patent Text Search

These patents were obtained by searching patent claims

HUMALOG MIX 75/25 Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Humalog Mix 75/25

Introduction to Humalog Mix 75/25

Humalog Mix 75/25, a formulation of rapid-acting insulin lispro and intermediate-acting neutral protamine lispro in a 75:25 ratio, is a significant product in the biologic drug market. Developed by Eli Lilly and Company, this insulin preparation has garnered substantial attention for its efficacy and patient preference.

Patient Preference and Willingness to Pay

Studies have shown that patients, particularly in Canada, prefer Humalog Mix 75/25 over traditional human 30/70 insulin. A cost-benefit analysis revealed that approximately 84% of Canadian taxpayers preferred Humalog Mix 75/25 and were willing to pay a premium for it. On average, they were willing to pay $Can35.28 per month, which is at least twice the incremental monthly cost of the drug[1].

Market Demand and Growth

The demand for Humalog Mix 75/25 is driven by several factors, including the rising prevalence of diabetes and the need for more effective and convenient insulin therapies. In the United States, which accounts for over 56% of the global sales of Humalog, the product is available in various formulations, including Humalog Mix 75/25, Humalog U-100, and Humalog Mix 50/50[5].

Financial Performance of Eli Lilly and Company

Eli Lilly and Company, the manufacturer of Humalog Mix 75/25, has seen significant financial growth. In 2023, the company's revenue was $34.12 billion, an increase of 19.56% from the previous year's $28.54 billion. This growth is indicative of the strong market performance of their biologic drugs, including Humalog Mix 75/25[2].

Market Size and Forecast

The biologics market, which includes Humalog Mix 75/25, is expected to experience robust growth. The global biologics market size was valued at USD 349.6 billion in 2023 and is projected to reach USD 699.5 billion by 2032, with a compound annual growth rate (CAGR) of 7.8% during the forecast period. This growth is driven by the increasing prevalence of chronic diseases, technological advancements, and the growing adoption of biosimilars[3].

Regional Insights

North America, particularly the United States, holds a dominant position in the biologics market, including the sales of Humalog Mix 75/25. The region's well-developed pharmaceutical industry, access to advanced healthcare facilities, and streamlined regulatory frameworks contribute to the high demand for biologic drugs. The United States accounts for the highest sales of Humalog globally, making it a critical market for Eli Lilly and Company[4].

Competitive Landscape

The biologics market is highly competitive, with several key players such as Roche, Novartis, and Amgen. However, Eli Lilly and Company's strong portfolio, including Humalog Mix 75/25, positions it favorably in the market. The company's continuous innovation and strategic collaborations further enhance its market presence[4].

Technological Advancements and Innovation

Technological advancements in drug delivery systems are also driving the market for Humalog Mix 75/25. For instance, companies like Oramed Pharmaceuticals Inc. are working on developing oral insulin products, which could potentially disrupt the traditional insulin market. However, Humalog Mix 75/25 remains a preferred choice due to its established efficacy and patient preference[5].

Regulatory Environment

The regulatory environment plays a crucial role in the biologics market. In North America, regulatory frameworks are generally more streamlined, allowing for faster approvals and market entry for new biologic drugs. The Inflation Reduction Act, for example, provides 13-year patent protection for new biologics, incentivizing further investment and innovation in this sector[4].

Economic Value and Reimbursement

The economic value of Humalog Mix 75/25 is significant, as it offers substantial benefits to patients and healthcare systems. The study in Canada indicated that the overall net gain from using Humalog Mix 75/25 suggests it represents good value for money and should be considered for reimbursement by government formularies and other third-party payers[1].

Impact of Chronic Diseases

The increasing prevalence of chronic diseases such as diabetes, cancer, and autoimmune disorders is a key driver of the biologics market. Humalog Mix 75/25 addresses the need for effective insulin therapy, making it a vital component in the management of diabetes. The rising burden of these diseases fuels the demand for advanced therapeutic interventions, including biologic drugs[3][4].

Future Outlook

The future outlook for Humalog Mix 75/25 is promising, given the growing demand for biologic drugs and the expanding market size. As the biopharmaceutical industry continues to evolve, technological advancements, regulatory approvals, and healthcare infrastructure developments will play pivotal roles in shaping the market trajectory.

Key Takeaways

  • Patient Preference: Patients prefer Humalog Mix 75/25 over traditional insulin due to its efficacy and convenience.
  • Financial Growth: Eli Lilly and Company has seen significant financial growth, partly due to the strong performance of Humalog Mix 75/25.
  • Market Forecast: The biologics market, including Humalog Mix 75/25, is expected to grow substantially by 2032.
  • Regional Dominance: North America, particularly the United States, dominates the sales of Humalog Mix 75/25.
  • Regulatory Environment: Streamlined regulatory frameworks in North America support the market growth of biologic drugs.
  • Economic Value: Humalog Mix 75/25 offers good value for money and should be considered for reimbursement.

FAQs

What is Humalog Mix 75/25?

Humalog Mix 75/25 is a biologic drug formulation consisting of rapid-acting insulin lispro and intermediate-acting neutral protamine lispro in a 75:25 ratio, used for the treatment of diabetes.

Why do patients prefer Humalog Mix 75/25?

Patients prefer Humalog Mix 75/25 due to its efficacy and convenience compared to traditional human 30/70 insulin. A study showed that 84% of Canadian taxpayers preferred this formulation and were willing to pay a premium for it[1].

How is the financial performance of Eli Lilly and Company related to Humalog Mix 75/25?

Eli Lilly and Company's financial growth is partly attributed to the strong market performance of Humalog Mix 75/25. In 2023, the company's revenue increased by 19.56% from the previous year[2].

What is the projected market size for biologic drugs by 2032?

The global biologics market is expected to reach USD 699.5 billion by 2032, with a CAGR of 7.8% during the forecast period[3].

Why is North America a significant market for Humalog Mix 75/25?

North America, particularly the United States, holds a dominant position in the biologics market due to its well-developed pharmaceutical industry, advanced healthcare facilities, and streamlined regulatory frameworks[4].

How does the regulatory environment impact the market for Humalog Mix 75/25?

The regulatory environment in North America, with its streamlined frameworks and extended patent protection, supports the market growth and innovation in biologic drugs like Humalog Mix 75/25[4].

Sources

  1. The economic value of a new insulin preparation, Humalog Mix 25: PubMed.
  2. Eli Lilly and Company (NEO: LLY) Stock Price & Overview: StockAnalysis.
  3. Biologics Market Size to Reach USD 699.5 Billion by 2032: BioSpace.
  4. Biological Drugs Market: Global Industry Analysis: Maximize Market Research.
  5. North America Human Insulin Drugs Market Trends: Mordor Intelligence.

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