TORSEMIDE - Generic Drug Details

What are the generic drug sources for torsemide and what is the scope of freedom to operate?

Torsemide is the generic ingredient in three branded drugs marketed by Roche, Am Regent, West-ward Pharms Int, Norvium Bioscience, Sarfe Pharms, Aurobindo Pharma, Heritage, Hetero Labs Ltd Iii, Hikma, Pliva Pharm Ind, Strides Pharma, Sun Pharm Inds, and Teva, and is included in fourteen NDAs. There is one patent protecting this compound. Additional information is available in the individual branded drug profile pages.

Torsemide has two patent family members in two countries.

There are sixteen drug master file entries for torsemide. Twenty-one suppliers are listed for this compound.

Summary for TORSEMIDE

International Patents:	2
US Patents:	1
Tradenames:	3
Applicants:	13
NDAs:	14
Drug Master File Entries:	16
Finished Product Suppliers / Packagers:	21
Raw Ingredient (Bulk) Api Vendors:	126
Clinical Trials:	23
Patent Applications:	5,821
Drug Prices:	Drug price trends for TORSEMIDE
Drug Sales Revenues:	Drug sales revenues for TORSEMIDE
What excipients (inactive ingredients) are in TORSEMIDE?	TORSEMIDE excipients list
DailyMed Link:	TORSEMIDE at DailyMed

See drug prices for TORSEMIDE

See drug sales revenues for TORSEMIDE

Recent Clinical Trials for TORSEMIDE

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
Sarfez Pharmaceuticals, Inc.	Phase 2
Assiut University	Phase 4
Duke University	Phase 3

See all TORSEMIDE clinical trials

Pharmacology for TORSEMIDE

Drug Class	Loop Diuretic
Physiological Effect	Increased Diuresis at Loop of Henle

US Patents and Regulatory Information for TORSEMIDE

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Aurobindo Pharma	TORSEMIDE	torsemide	TABLET;ORAL	078249-002	Oct 17, 2007	AB	RX	No	No
Aurobindo Pharma	TORSEMIDE	torsemide	TABLET;ORAL	078249-001	Oct 17, 2007	AB	RX	No	No
Am Regent	TORSEMIDE	torsemide	SOLUTION;INTRAVENOUS	090656-002	Apr 21, 2010		DISCN	No	No

Expired US Patents for TORSEMIDE

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Norvium Bioscience	DEMADEX	torsemide	TABLET;ORAL	020136-002	Aug 23, 1993	4,018,929
Norvium Bioscience	DEMADEX	torsemide	TABLET;ORAL	020136-003	Aug 23, 1993	RE34672
Norvium Bioscience	DEMADEX	torsemide	TABLET;ORAL	020136-003	Aug 23, 1993	4,018,929

International Patents for TORSEMIDE

Country	Patent Number	Title	Estimated Expiration
European Patent Office	3065718	FORMULATIONS À LIBÉRATION CONTRÔLÉE COMPRENANT DU TORSÉMIDE (CONTROLLED-RELEASE FORMULATIONS COMPRISING TORSEMIDE)
World Intellectual Property Organization (WIPO)	2015050570

TORSEMIDE Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Torsemide

Introduction

Torsemide, a potent loop diuretic, is widely used in the treatment of hypertension, edema associated with heart failure, renal disease, and cirrhosis. The market for torsemide is experiencing significant growth, driven by several key factors. Here, we delve into the market dynamics and financial trajectory of torsemide.

Market Size and Projections

The global torsemide market was valued at USD 100 billion in 2023 and is projected to reach USD 140.71 billion by 2031, growing at a compound annual growth rate (CAGR) of 5% from 2024 to 2031[1].

Drivers of Market Growth

Several factors are driving the growth of the torsemide market:

Increasing Incidence of Cardiovascular Diseases

The rising incidence of cardiovascular disorders such as heart failure and hypertension is a major driver. These conditions require effective diuretic therapy, increasing the demand for torsemide[1].

Growing Prevalence of Renal Diseases

The increasing prevalence of renal diseases, such as chronic kidney disease, necessitates the use of torsemide to control fluid retention and maintain renal function[1].

Aging Population

The growing elderly population, who are more likely to suffer from cardiovascular and renal diseases, is another significant driver of market growth[1].

Improvements in Formulations and Delivery Systems

Continuous research and development (R&D) to improve torsemide formulations and delivery systems enhance its therapeutic profile, further driving market growth[1].

Market Segmentation

The torsemide market is segmented based on several criteria:

By Type

• Hospitals
• Clinics
• Retail Pharmacies
• E-commerce[1]

By Application

• Tablets
• Injection
• Oral Solution
• Others[1]

By Geography

• North America
• Europe
• Asia-Pacific
• South America
• Middle-East and Africa[1]

Pharmacoeconomic Analysis

Pharmacoeconomic studies have shown that despite higher acquisition costs, torsemide can reduce overall treatment costs for congestive heart failure (CHF) by reducing hospital admissions and readmissions.

Cost-Effectiveness

Studies have indicated that torsemide, although more expensive than furosemide in terms of drug acquisition costs, does not significantly differ in total CHF/cardiovascular-related medical costs. In fact, torsemide has been associated with reduced hospital admission rates and lower overall direct medical costs in several studies[2][3].

Quality of Life

Torsemide has been shown to improve quality of life measures, such as reducing fatigue and improving functional class of CHF severity. For instance, a study found that patients receiving torsemide had significantly better quality-of-life scores compared to those receiving furosemide, particularly at month 4 of treatment[2][3].

Competitive Landscape

The torsemide market is competitive, with several key players:

Major Companies

• Pfizer Inc.
• Teva Pharmaceutical Industries Ltd.
• Mylan N.V.
• Zydus Pharmaceuticals (USA) Inc.
• Merck & Co. Inc.[1]

These companies are profiled in market reports, which include details on their market entry year and various market-related factors.

Market Trends and Analysis

Porter’s Five Forces Analysis

Market reports include a detailed Porter’s Five Forces analysis, which examines the bargaining power of buyers and suppliers, the threat of new entrants, the threat of substitutes, and the degree of competition in the global torsemide market[1].

PESTEL and SWOT Analysis

Reports also provide PESTEL (Political, Economic, Social, Technological, Environmental, and Legal) and SWOT (Strengths, Weaknesses, Opportunities, and Threats) analyses to give a comprehensive view of the market’s dynamics and potential future directions[4].

Financial Implications

Revenue and Growth Rate

The torsemide market is expected to grow significantly, with a projected CAGR of 5% from 2024 to 2031. This growth is driven by increasing demand and the expanding elderly population[1].

Cost Savings

Despite higher drug acquisition costs, torsemide can lead to significant cost savings in the long term by reducing hospital admissions and other healthcare resource use. For example, a study showed that average monthly costs for patients decreased by 56.6% after 5.1 months of torsemide treatment[3].

Conclusion

The torsemide market is poised for substantial growth, driven by the increasing incidence of cardiovascular and renal diseases, improvements in drug formulations, and the growing elderly population. Despite higher acquisition costs, torsemide offers significant long-term cost savings and improved quality of life for patients.

Key Takeaways

• The global torsemide market is projected to reach USD 140.71 billion by 2031.
• The market is driven by the increasing incidence of cardiovascular and renal diseases.
• Torsemide offers cost savings by reducing hospital admissions and healthcare resource use.
• The drug improves quality of life for patients with CHF.
• Major players in the market include Pfizer Inc., Teva Pharmaceutical Industries Ltd., and others.

FAQs

What is the projected growth rate of the torsemide market from 2024 to 2031?

The torsemide market is expected to grow at a CAGR of 5% from 2024 to 2031[1].

Which segment accounts for the largest share of the global torsemide market?

The market is segmented by type (hospitals, clinics, retail pharmacies, e-commerce) and application (tablets, injection, oral solution, others), but specific segment dominance can vary based on regional and application-specific data[1].

How does torsemide compare to furosemide in terms of cost-effectiveness?

Despite higher drug acquisition costs, torsemide is associated with reduced overall treatment costs for CHF by reducing hospital admissions and readmissions, making it cost-effective in the long term[2][3].

What are the key drivers of the torsemide market growth?

Key drivers include the increasing incidence of cardiovascular diseases, growing prevalence of renal diseases, aging population, and improvements in drug formulations and delivery systems[1].

Which companies are major players in the torsemide market?

Major companies include Pfizer Inc., Teva Pharmaceutical Industries Ltd., Mylan N.V., Zydus Pharmaceuticals (USA) Inc., and Merck & Co. Inc.[1].

Sources

1. Market Research Intellect - Torsemide Market Size and Projections
2. PubMed - A pharmacoeconomic assessment of torsemide and furosemide in patients with congestive heart failure
3. PubMed - Torasemide: a pharmacoeconomic review of its use in chronic heart failure
4. Cognitive Market Research - Torsemide Market Report 2024 (Global Edition)