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Last Updated: December 22, 2024

Aspirin; caffeine; propoxyphene hydrochloride - Generic Drug Details


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What are the generic sources for aspirin; caffeine; propoxyphene hydrochloride and what is the scope of freedom to operate?

Aspirin; caffeine; propoxyphene hydrochloride is the generic ingredient in six branded drugs marketed by Alra, Xanodyne Pharm, Ivax Sub Teva Pharms, Sandoz, Teva, and Watson Labs, and is included in seven NDAs. Additional information is available in the individual branded drug profile pages.

Summary for aspirin; caffeine; propoxyphene hydrochloride
US Patents:0
Tradenames:6
Applicants:6
NDAs:7
DailyMed Link:aspirin; caffeine; propoxyphene hydrochloride at DailyMed

US Patents and Regulatory Information for aspirin; caffeine; propoxyphene hydrochloride

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Ivax Sub Teva Pharms PROPOXYPHENE COMPOUND 65 aspirin; caffeine; propoxyphene hydrochloride CAPSULE;ORAL 083077-002 Dec 7, 1984 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Sandoz PROPOXYPHENE COMPOUND 65 aspirin; caffeine; propoxyphene hydrochloride CAPSULE;ORAL 080044-002 Sep 16, 1983 DISCN Yes No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Alra COMPOUND 65 aspirin; caffeine; propoxyphene hydrochloride CAPSULE;ORAL 084553-002 Aug 17, 1983 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Aspirin; caffeine; propoxyphene hydrochloride Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Aspirin, Caffeine, and Propoxyphene Hydrochloride

Introduction to Market Dynamics

Understanding the market dynamics of pharmaceuticals like aspirin, caffeine, and propoxyphene hydrochloride is crucial for investors, manufacturers, and healthcare professionals. Each of these drugs has unique market trends, driven by various factors such as demand, supply chain disruptions, regulatory changes, and health industry needs.

Aspirin Market Dynamics

Global Market Value and Growth

The aspirin drug market is projected to experience significant growth, driven primarily by the increasing prevalence of cardiovascular diseases. The global aspirin drug market is expected to rise from $2.938 billion in 2024 to $4.236 billion by 2034, with a CAGR of 3.8% over the next decade[5].

Regional Price Trends

In Q3 2024, aspirin prices in Asia, Europe, and North America showed an upward trajectory. In Asia, robust demand and tightening supply conditions led to firm pricing positions, especially in China. European aspirin prices were influenced by strong market fundamentals and supply chain disruptions, resulting in price hikes despite high logistics costs. In North America, the US market saw steady price appreciation due to rising production costs and supply chain bottlenecks[1].

Demand and Supply Factors

The demand for aspirin is driven by its widespread use in preventing cardiovascular diseases, which is fueled by lifestyle factors such as high-cholesterol diets and smoking. Supply chain disruptions, including elevated freight rates and geopolitical tensions, have contributed to the price increases[1].

Caffeine Market Dynamics

Global Market Value and Growth

The caffeine market is valued at $715.2 million in 2021 and is estimated to reach $1.194 billion by 2031, growing at a CAGR of 5.2% from 2022 to 2031. This growth is largely driven by increasing demand in the sports and health industries[2].

Segmental Growth

The natural caffeine segment is expected to witness significant growth, registering a CAGR of 5.5% during the forecast period. The food segment is also anticipated to grow, with a CAGR of 6.0%. Europe was the dominant region in 2021, while the Latin America, Middle East, and Africa (LAMEA) region is expected to grow at the highest rate, with a CAGR of 6.4%[2].

Applications and Demand

Caffeine's stimulating effects on cognition, mood, and performance have unlocked its potential in various industries, including sports and health. The growing demand for caffeinated products in these sectors is a key driver of the market's growth[2].

Propoxyphene Hydrochloride Market Dynamics

Regulatory Impact

Propoxyphene hydrochloride, an opioid analgesic, was withdrawn from the market in November 2010 due to significant safety concerns. The FDA recommended against its continued use after studies showed it could cause serious abnormal heart rhythms, particularly in elderly patients and those with renal insufficiency[3][4].

Post-Market Withdrawal Effects

Following the market withdrawal, users experienced an abrupt decline in opioid consumption, with many transitioning to other analgesics like tramadol and hydrocodone. This transition highlighted the need for policymakers to support appropriate treatment transitions and monitor responses following drug withdrawals[4].

Financial Impact

The withdrawal of propoxyphene hydrochloride from the market resulted in a significant shift in the analgesic market, with other opioids and non-opioid analgesics filling the gap. This shift has had financial implications for manufacturers and distributors, as they adapted to the new market landscape.

Financial Trajectory

Aspirin

The aspirin market is on a positive financial trajectory, driven by consistent demand and growing health concerns. With a projected market value of $4.236 billion by 2034, aspirin manufacturers are poised to benefit from this growth, especially those who can navigate supply chain challenges effectively[5].

Caffeine

The caffeine market is expected to reach $1.194 billion by 2031, with a CAGR of 5.2%. This growth presents lucrative opportunities for caffeine manufacturers, particularly those focusing on natural caffeine and food applications[2].

Propoxyphene Hydrochloride

The financial trajectory for propoxyphene hydrochloride is non-existent due to its market withdrawal. However, the impact of its withdrawal has led to increased demand for other analgesics, benefiting manufacturers of those drugs.

Key Factors Influencing Market Dynamics

Demand and Supply Chain

For aspirin and caffeine, robust demand and supply chain dynamics play crucial roles. Aspirin's demand is driven by health needs, while caffeine's demand is fueled by sports and health industries. Supply chain disruptions can significantly impact pricing and availability[1][2].

Regulatory Changes

Regulatory actions, such as the FDA's recommendation against propoxyphene hydrochloride, can drastically alter market dynamics. Manufacturers must be prepared to adapt to such changes and ensure compliance with regulatory requirements[3][4].

Health Industry Trends

The prevalence of cardiovascular diseases and the growing focus on health and wellness are key drivers for the aspirin and caffeine markets. Understanding these trends is essential for market participants to make informed decisions[5][2].

Conclusion

The market dynamics and financial trajectories of aspirin, caffeine, and propoxyphene hydrochloride are shaped by a complex interplay of demand, supply chain factors, regulatory changes, and health industry trends.

Key Takeaways

  • Aspirin Market: Expected to grow to $4.236 billion by 2034, driven by cardiovascular disease prevention.
  • Caffeine Market: Projected to reach $1.194 billion by 2031, fueled by demand in sports and health industries.
  • Propoxyphene Hydrochloride: Withdrawn from the market due to safety concerns, leading to a shift in the analgesic market.

FAQs

What are the primary drivers of the aspirin market growth?

The primary drivers include the increasing prevalence of cardiovascular diseases and the widespread use of aspirin for prevention.

How is the caffeine market expected to grow?

The caffeine market is expected to grow at a CAGR of 5.2% from 2022 to 2031, driven by demand in the sports and health industries.

Why was propoxyphene hydrochloride withdrawn from the market?

Propoxyphene hydrochloride was withdrawn due to significant safety concerns, including its potential to cause serious abnormal heart rhythms.

What are the implications of supply chain disruptions on the aspirin market?

Supply chain disruptions, such as elevated freight rates and geopolitical tensions, have led to price increases and firm pricing positions by suppliers.

How has the withdrawal of propoxyphene hydrochloride affected the analgesic market?

The withdrawal led to an abrupt decline in opioid consumption, with users transitioning to other analgesics like tramadol and hydrocodone, and highlighted the need for policymakers to support treatment transitions.

Sources

  1. Procurement Resource: Aspirin Price Trend, Index, News, Chart, Database.
  2. EIN Presswire: Caffeine Market Set to Reach $1.2 Billion by 2031, Fueled by Growing Demand in Sports and Health Industries.
  3. FDA: FDA recommends against the continued use of propoxyphene.
  4. PubMed: Analgesic Substitutes, Doses, and Adverse Events.
  5. PR Newswire: Aspirin Drug Market to Soar to US$4.2 Billion by 2034, Driven by Combination Aspirins' Dominance.

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