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Last Updated: December 22, 2024

Hydrochlorothiazide; labetalol hydrochloride - Generic Drug Details


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What are the generic drug sources for hydrochlorothiazide; labetalol hydrochloride and what is the scope of freedom to operate?

Hydrochlorothiazide; labetalol hydrochloride is the generic ingredient in two branded drugs marketed by Schering and Glaxosmithkline, and is included in two NDAs. Additional information is available in the individual branded drug profile pages.

Summary for hydrochlorothiazide; labetalol hydrochloride
US Patents:0
Tradenames:2
Applicants:2
NDAs:2
Clinical Trials: 1
DailyMed Link:hydrochlorothiazide; labetalol hydrochloride at DailyMed
Recent Clinical Trials for hydrochlorothiazide; labetalol hydrochloride

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SponsorPhase
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VA Office of Research and Development

See all hydrochlorothiazide; labetalol hydrochloride clinical trials

US Patents and Regulatory Information for hydrochlorothiazide; labetalol hydrochloride

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Schering NORMOZIDE hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019046-004 Apr 6, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Glaxosmithkline TRANDATE HCT hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019174-001 Apr 10, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Schering NORMOZIDE hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019046-001 Apr 6, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Glaxosmithkline TRANDATE HCT hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019174-003 Apr 10, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Schering NORMOZIDE hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019046-003 Apr 6, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Glaxosmithkline TRANDATE HCT hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019174-002 Apr 10, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Glaxosmithkline TRANDATE HCT hydrochlorothiazide; labetalol hydrochloride TABLET;ORAL 019174-004 Apr 10, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for hydrochlorothiazide; labetalol hydrochloride

Hydrochlorothiazide; labetalol hydrochloride Market Analysis and Financial Projection Experimental

Hydrochlorothiazide and Labetalol Hydrochloride: Market Dynamics and Financial Trajectory

Introduction

Hydrochlorothiazide and labetalol hydrochloride are two widely used medications in the management of hypertension and related cardiovascular conditions. Understanding the market dynamics and financial trajectory of these drugs is crucial for stakeholders, including pharmaceutical companies, healthcare providers, and investors.

Market Drivers for Hydrochlorothiazide

Increasing Prevalence of Hypertension

The global prevalence of hypertension is a significant driver for the hydrochlorothiazide market. According to the World Health Organization (WHO), approximately 1.13 billion people worldwide suffer from hypertension, with this number expected to rise to 29% by 2025, particularly in economically developing nations[1][4].

Geriatric Population Growth

The aging population is more susceptible to chronic diseases such as hypertension and heart disease, which further boosts the demand for hydrochlorothiazide. As the global population ages, the need for effective antihypertensive medications like hydrochlorothiazide is expected to increase[1][2].

Combination Therapies

The trend towards combination drug therapies, where hydrochlorothiazide is often used alongside other antihypertensives, enhances its therapeutic effectiveness and contributes to market growth[2].

Healthcare Expenditure and R&D

Increasing healthcare expenditure and ongoing research and development activities aimed at improving patient compliance and minimizing side effects also propel the market forward[1][2].

Market Restraints for Hydrochlorothiazide

Side Effects

Despite its efficacy, hydrochlorothiazide is associated with several side effects, including significant decreases in serum potassium, increases in uric acid and urea nitrogen, which can hamper market growth[3].

Market Trends for Hydrochlorothiazide

New Product Launches

The launch of novel formulations and drug delivery systems is a key trend in the hydrochlorothiazide market. These innovations aim to improve patient compliance and reduce side effects, thereby enhancing market prospects[1][2].

Impact of COVID-19

The COVID-19 pandemic has indirectly influenced the hydrochlorothiazide market by highlighting the importance of healthcare infrastructure and the need for effective treatments for chronic conditions. This has led to increased investment in pharmaceutical research and development[1].

Financial Trajectory for Hydrochlorothiazide

Market Forecast

The global hydrochlorothiazide market is forecasted to see significant growth from 2021 to 2030, driven by the increasing prevalence of hypertension and other cardiovascular diseases. The market is expected to benefit from rising healthcare expenditure and advancements in drug formulations[1][4].

Investment Opportunities

Setting up a hydrochlorothiazide manufacturing plant involves substantial capital investments, but it also presents lucrative opportunities. The report provides detailed insights into project economics, including capital investments, operating costs, revenue projections, and financial analysis, which can guide entrepreneurs and stakeholders in making informed decisions[2].

Market Dynamics for Labetalol Hydrochloride

Efficacy in Elderly Patients

Labetalol hydrochloride is particularly effective in elderly patients with hypertension, offering advantages over thiazide diuretics like hydrochlorothiazide. It significantly reduces standing systolic and diastolic blood pressures and has a lower rate of rise in diastolic blood pressure and mean arterial pressure during the acceleration period[3].

Comparative Analysis

Studies comparing labetalol and hydrochlorothiazide in elderly patients show that both antihypertensives effectively control blood pressure, but labetalol may offer unique advantages, such as fewer side effects related to serum potassium and uric acid levels[3].

Market Drivers for Labetalol Hydrochloride

Growing Demand for Antihypertensives

The increasing demand for antihypertensive medications, driven by the rising prevalence of hypertension and related cardiovascular diseases, is a key driver for labetalol hydrochloride. Its efficacy and safety profile, especially in elderly patients, contribute to its market growth[3].

Combination Therapies

Similar to hydrochlorothiazide, labetalol hydrochloride is often used in combination therapies, which enhances its market prospects by providing a comprehensive treatment approach for hypertension[3].

Financial Trajectory for Labetalol Hydrochloride

Market Share

While specific financial projections for labetalol hydrochloride are not as detailed as those for hydrochlorothiazide, its market share is expected to grow due to its efficacy and the increasing demand for antihypertensive medications. The financial trajectory is likely to be positive, driven by the overall growth in the antihypertensive market[3].

Competitive Landscape

The competitive landscape for labetalol hydrochloride includes other antihypertensive medications. However, its unique advantages, particularly in elderly patients, position it favorably in the market. The financial performance of labetalol hydrochloride will depend on its market segmentation, regional breakup, and the competitive intensity within the antihypertensive drug market[3].

Regional Breakup and Market Segmentation

Hydrochlorothiazide

The global hydrochlorothiazide market is segmented by type (tablet, capsule, and liquid), application (hypertension, fluid retention, heart attack, kidney failure, and others), and end user (hospital, drug store, and others). The regional breakup shows significant growth in economically developing nations due to the increasing prevalence of hypertension and other cardiovascular diseases[1][4].

Labetalol Hydrochloride

While detailed segmentation data for labetalol hydrochloride is not as extensive, it is clear that its market performance will be influenced by regional healthcare needs and the prevalence of hypertension. The drug's efficacy in specific patient groups, such as the elderly, will also play a crucial role in its market segmentation and regional performance[3].

Key Benefits for Stakeholders

Detailed Market Analysis

Reports on the hydrochlorothiazide market provide a detailed quantitative analysis, current trends, and future estimations, which are essential for identifying prevailing opportunities and making strategic assessments. This includes Porter’s five forces analysis to illustrate the potency of buyers and suppliers in the market[1][4].

Project Economics

For those considering setting up a hydrochlorothiazide manufacturing plant, detailed project economics, including capital investments, operating costs, and revenue projections, are crucial. This information helps stakeholders make informed decisions and venture into successful manufacturing units[2].

Key Takeaways

  • Increasing Prevalence of Hypertension: The rising number of patients suffering from hypertension globally is a significant driver for both hydrochlorothiazide and labetalol hydrochloride.
  • Geriatric Population: The aging population's susceptibility to chronic diseases like hypertension boosts the demand for these medications.
  • Combination Therapies: The trend towards combination drug therapies enhances the market prospects for both drugs.
  • Side Effects: Hydrochlorothiazide's side effects can hamper its market growth, while labetalol hydrochloride's safety profile is a market advantage.
  • Financial Trajectory: Both drugs are expected to see significant growth, driven by increasing healthcare expenditure and advancements in drug formulations.

FAQs

What are the primary drivers of the hydrochlorothiazide market?

The primary drivers include the increasing prevalence of hypertension, the growing geriatric population, and the trend towards combination drug therapies.

How does labetalol hydrochloride compare to hydrochlorothiazide in terms of efficacy?

Labetalol hydrochloride is particularly effective in elderly patients, offering advantages over hydrochlorothiazide in terms of fewer side effects related to serum potassium and uric acid levels.

What are the key factors to consider when setting up a hydrochlorothiazide manufacturing plant?

Key factors include capital investments, operating costs, revenue projections, and detailed financial analysis to ensure a successful and profitable manufacturing unit.

How has the COVID-19 pandemic impacted the hydrochlorothiazide market?

The pandemic has indirectly influenced the market by highlighting the importance of healthcare infrastructure and the need for effective treatments for chronic conditions, leading to increased investment in pharmaceutical research and development.

What is the expected market growth for hydrochlorothiazide from 2021 to 2030?

The global hydrochlorothiazide market is forecasted to see significant growth from 2021 to 2030, driven by the increasing prevalence of hypertension and other cardiovascular diseases, along with rising healthcare expenditure and advancements in drug formulations.

Sources

  1. Allied Market Research - Hydrochlorothiazide Market Size | Industry Growth, (2021-2030)
  2. IMARC Group - Hydrochlorothiazide Manufacturing Plant Project Report 2024
  3. PubMed - Comparison of labetalol and hydrochlorothiazide in elderly patients
  4. EIN Presswire - Hydrochlorothiazide Market To See Incredible Growth During 2021–2030

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