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Last Updated: December 22, 2024

Metoprolol fumarate - Generic Drug Details


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What are the generic drug sources for metoprolol fumarate and what is the scope of patent protection?

Metoprolol fumarate is the generic ingredient in one branded drug marketed by Novartis and is included in one NDA. Additional information is available in the individual branded drug profile pages.

There is one drug master file entry for metoprolol fumarate.

Summary for metoprolol fumarate
Recent Clinical Trials for metoprolol fumarate

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Haining Health-Coming Biotech Co., Ltd.Phase 2
Alphacait, LLCPhase 2

See all metoprolol fumarate clinical trials

Anatomical Therapeutic Chemical (ATC) Classes for metoprolol fumarate

US Patents and Regulatory Information for metoprolol fumarate

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-004 Dec 27, 1989 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-001 Dec 27, 1989 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-003 Dec 27, 1989 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-002 Dec 27, 1989 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for metoprolol fumarate

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-003 Dec 27, 1989 4,892,739 ⤷  Subscribe
Novartis LOPRESSOR metoprolol fumarate TABLET, EXTENDED RELEASE;ORAL 019786-004 Dec 27, 1989 4,892,739 ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >Patent No. >Patent Expiration

Metoprolol fumarate Market Analysis and Financial Projection Experimental

Metoprolol Tartrate Market Dynamics and Financial Trajectory

Market Overview

Metoprolol tartrate, a beta-blocker used to treat various cardiovascular conditions, is a significant player in the pharmaceutical market. Here’s a detailed look at its market dynamics and financial trajectory.

Market Size and Growth

The metoprolol tartrate market is projected to experience steady growth over the coming years. As of 2023, the market size was valued at USD 6.31 billion and is expected to reach USD 8.6 billion by 2032, growing at a CAGR of 3.5% from 2024 to 2032[1][3].

Geographical Dominance

North America holds the largest share of the metoprolol tartrate market. This dominance is attributed to several factors, including a large population affected by cardiovascular diseases, well-developed healthcare systems, and higher spending on healthcare. The region's high prevalence of hypertension and other noncommunicable diseases further solidifies its position as a key market[1][5].

Drivers of Market Growth

Rising Prevalence of Cardiovascular Diseases

The increasing incidence of cardiovascular diseases, driven by an aging global population and lifestyle factors, is a significant driver of the metoprolol tartrate market. As more people develop conditions such as hypertension, angina, and heart failure, the demand for effective medications like metoprolol tartrate is expected to rise[3].

Patient Education and Adherence

Investing in patient education and adherence programs can improve patient outcomes and loyalty. By helping patients understand the importance of adhering to their metoprolol tartrate regimen, pharmaceutical companies can enhance the effectiveness of the treatment and reduce the risk of complications[3].

Collaboration with Healthcare Providers

Building collaborative relationships with healthcare providers, hospitals, and clinics can secure preferred formulary status for metoprolol tartrate. This ensures its inclusion in treatment protocols, further boosting its market presence[3].

Restraints and Challenges

Healthcare System Reimbursement

One of the major challenges facing the metoprolol tartrate market is the complexity of healthcare system reimbursement. Variations in insurance coverage and reimbursement policies can affect the accessibility and affordability of the drug, potentially limiting its market growth[3].

Side Effects and Regulatory Constraints

The rising side effects associated with metoprolol tartrate and stringent government regulations are other factors that could hamper market growth. These challenges necessitate continuous monitoring and adaptation by pharmaceutical companies to ensure compliance and patient safety[5].

Cost-Effectiveness and Financial Considerations

Cost-Effectiveness Analysis

Studies have shown that metoprolol tartrate, when used in addition to conventional therapy for heart failure, offers a cost-effective solution. For instance, a study in Canada found that the incremental cost-effectiveness ratio (ICER) for metoprolol relative to conventional therapy alone was $4,140 per life-year gained, indicating a favorable cost-effectiveness profile[2].

Retail Price and Insurance Coverage

The cost of metoprolol tartrate can vary significantly based on factors such as treatment plan, insurance coverage, and the pharmacy used. Generic versions of the drug, which are as safe and effective as brand-name versions, tend to be more affordable. However, prices can still be higher for those without insurance, and the form of the drug (e.g., immediate-release vs. extended-release) also affects the cost[4].

Regional Analysis

North America

North America continues to dominate the metoprolol tartrate market due to its high prevalence of heart diseases and well-developed healthcare infrastructure. The region's large population and higher healthcare spending contribute to its significant market share[1][5].

Asia-Pacific

The Asia-Pacific region is expected to experience rapid growth during the forecast period. This growth is driven by increasing regional investments in healthcare and the rising application of metoprolol tartrate to treat hypertension and angina in this region[3][5].

Market Segmentation

The metoprolol tartrate market is segmented based on route of administration (tablets, injectable), application (hypertension, cardiovascular, others), and distribution channel (hospitals, retail pharmacies, online pharmacies). The oral route of administration, particularly tablets, dominates the market due to growing demand and ease of use[3].

Key Takeaways

  • The metoprolol tartrate market is projected to grow at a CAGR of 3.5% from 2024 to 2032.
  • North America holds the largest market share due to high prevalence of cardiovascular diseases and well-developed healthcare systems.
  • Rising prevalence of cardiovascular diseases and patient education/adherence programs are key drivers of market growth.
  • Healthcare system reimbursement and side effects are significant challenges.
  • The drug is cost-effective when used in addition to conventional therapy for heart failure.

Frequently Asked Questions (FAQs)

What is the primary use of metoprolol tartrate?

Metoprolol tartrate is primarily used to treat hypertension (high blood pressure), angina, heart failure, and to reduce the risk of death associated with a recent heart attack[4].

How does metoprolol tartrate work?

Metoprolol tartrate works by interfering with the impact of various chemicals in the body, including epinephrine, on the heart and blood vessels. It is a beta-blocker that reduces heart rate and blood pressure[1][5].

What are the different forms of metoprolol?

Metoprolol is available in several forms, including immediate-release (IR) oral tablets, extended-release (ER) oral tablets, ER oral capsules, and a liquid solution for intravenous (IV) injection[4].

How much does metoprolol tartrate cost without insurance?

The cost of metoprolol tartrate without insurance can vary based on factors such as the quantity prescribed, dosage, and pharmacy used. It is generally higher for those without insurance[4].

Is metoprolol tartrate cost-effective for heart failure treatment?

Yes, metoprolol tartrate is cost-effective when used in addition to conventional therapy for heart failure. It confers a survival benefit at a relatively low cost, with an ICER of $4,140 per life-year gained[2].

Cited Sources:

  1. Metoprolol Tartrate Market-Current Analysis by Market Share | IMR
  2. Cost-effectiveness of beta-blocker therapy with metoprolol ... - PubMed
  3. Global Metoprolol Tartrate Market Size, Evaluating Share & Forecast By 2031
  4. Metoprolol cost 2024: Coupons and more - MedicalNewsToday
  5. Metoprolol Tartrate Market Size Report, 2022-2027 - IndustryARC

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