Details for Patent: 10,125,149

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Which drugs does patent 10,125,149 protect, and when does it expire?

Patent 10,125,149 protects ZERBAXA and is included in one NDA.

This patent has four patent family members in three countries.

Summary for Patent: 10,125,149

Title:	Synthesis of cephalosporin compounds
Abstract:	Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.
Inventor(s):	Waller; David (Somerville, MA), Gazda; Gregory (Sudbury, MA), Minden; Zachary (Watsonville, CA), Barton; Lisa (Haverhill, MA), Leigh; Clifton (Windham, NH)
Assignee:	Merck Sharp & Dohme Corp. (Rahway, NJ)
Application Number:	15/503,907
Patent Claim Types: see list of patent claims	Composition; Compound;

Drugs Protected by US Patent 10,125,149

Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Cubist Pharms Llc	ZERBAXA	ceftolozane sulfate; tazobactam sodium	POWDER;INTRAVENOUS	206829-001	Dec 19, 2014		RX	Yes	Yes	⤷ Sign Up	⤷ Sign Up	Y				⤷ Sign Up
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

Foreign Priority and PCT Information for Patent: 10,125,149

PCT Information
PCT Filed	August 14, 2015	PCT Application Number:	PCT/US2015/045287
PCT Publication Date:	February 18, 2016	PCT Publication Number:	WO2016/025839

International Family Members for US Patent 10,125,149

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
China	106795175	⤷ Sign Up
China	110204558	⤷ Sign Up
European Patent Office	3180347	⤷ Sign Up
World Intellectual Property Organization (WIPO)	2016025839	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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