Details for Patent: 4,954,348

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Summary for Patent: 4,954,348

Title:	Non-ionic polyol contrast media from ionic contrast media
Abstract:	Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
Inventor(s):	Sovak; Milos (Rancho Santa Fe, CA), Ranganathan; Ramachandran (Princeton, NJ)
Assignee:	Cook Imaging Corporation (Bloomington, IN)
Application Number:	07/214,663
Patent Claim Types: see list of patent claims	Formulation; Compound;

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