Detailed Analysis of the Scope and Claims of United States Patent 8,114,885
Introduction
United States Patent 8,114,885, titled "Chemical compounds," is a patent that describes novel pyrimidine derivative compounds. These compounds are identified as inhibitors of VEGFR-2 kinase activity, which is significant in the context of cancer treatment. Here, we will delve into the scope, claims, and the broader patent landscape surrounding this invention.
Background
VEGFR-2 (Vascular Endothelial Growth Factor Receptor 2) is a key target in the treatment of various cancers, as it plays a crucial role in angiogenesis, the process by which new blood vessels form from pre-existing ones. Inhibitors of VEGFR-2 kinase activity are used to prevent the growth of new blood vessels that supply nutrients to tumors, thereby inhibiting tumor growth.
Scope of the Patent
The patent covers a class of chemical compounds, specifically pyrimidine derivatives, that act as inhibitors of VEGFR-2 kinase activity. Here are some key aspects of the scope:
Chemical Structure
The patent describes the chemical structure of these pyrimidine derivatives in detail. These compounds include various substituents such as methyl, amino, indazol, and alkyl groups, among others[4].
Therapeutic Use
The primary therapeutic use of these compounds is in the treatment of cancers, including breast cancer, colon cancer, and other neoplasms. The patent highlights the potential of these compounds in anticancer therapy, either as standalone treatments or in combination with other therapies like radiotherapy[4].
Pharmaceutical Composition
The patent also covers the pharmaceutical compositions containing these compounds, including formulations with diluting agents, pharmaceutical excipients, and drug carriers. This ensures that the compounds can be effectively delivered and administered to patients[4].
Claims of the Patent
The claims of the patent are critical in defining the scope of protection granted to the inventors. Here are some key claims:
Independent Claims
The patent includes independent claims that describe the novel pyrimidine derivative compounds and their use as VEGFR-2 kinase inhibitors. These claims specify the chemical structure and the therapeutic applications of the compounds[4].
Dependent Claims
Dependent claims further narrow down the scope by specifying particular substituents, formulations, and methods of use. For example, claims may specify the use of these compounds in treating specific types of cancer or in combination with other treatments[4].
Patent Landscape
Understanding the patent landscape is essential for assessing the novelty and non-obviousness of the invention, as well as identifying potential competitors and collaborators.
Prior Art
The patent cites prior art related to VEGFR-2 kinase inhibitors and other similar compounds. This includes references to existing patents and publications that describe related chemical structures and therapeutic uses[4].
International Patent Offices
The global patent landscape for VEGFR-2 kinase inhibitors involves multiple international patent offices. For instance, similar patents may be filed in the European Patent Office (EPO), Japan Patent Office (JPO), and other international intellectual property offices. Tools like the Common Citation Document (CCD) and Global Dossier can help in tracking related patent applications across different jurisdictions[1].
Competing Patents
Other patents in the same field may cover similar or overlapping subject matter. For example, patents related to other kinase inhibitors or cancer treatments could be relevant. Conducting a thorough search using resources like the USPTO's Patent Public Search tool and international databases is crucial for understanding the competitive landscape[1].
Economic and Market Impact
Patents like US 8,114,885 have significant economic and market implications. Here are a few points to consider:
Market Demand
The demand for effective cancer treatments drives the market for VEGFR-2 kinase inhibitors. Patents that cover novel and effective compounds can provide a competitive edge to the patent holders in the pharmaceutical market[4].
Licensing and Collaboration
Patent holders may license their technology to other companies or collaborate on further research and development. This can lead to new products and treatments entering the market, benefiting both the companies involved and patients[1].
Regulatory Environment
The regulatory environment, including FDA approvals and international regulatory standards, plays a critical role in the commercialization of these compounds. Patent holders must navigate these regulations to bring their products to market[2].
Key Takeaways
- Novel Compounds: US Patent 8,114,885 covers novel pyrimidine derivative compounds that inhibit VEGFR-2 kinase activity.
- Therapeutic Use: The primary use is in the treatment of cancers, including breast and colon cancer.
- Pharmaceutical Compositions: The patent includes formulations and methods of administration.
- Patent Landscape: The global patent landscape involves multiple international patent offices and competing patents.
- Economic Impact: The patent has significant economic implications, including market demand, licensing opportunities, and regulatory considerations.
FAQs
Q: What is the main therapeutic use of the compounds described in US Patent 8,114,885?
A: The main therapeutic use is in the treatment of cancers, particularly by inhibiting VEGFR-2 kinase activity.
Q: How do the compounds described in this patent differ from existing VEGFR-2 kinase inhibitors?
A: The compounds are novel pyrimidine derivatives with specific substituents that distinguish them from prior art.
Q: What resources can be used to search for related patents internationally?
A: Resources include the USPTO's Patent Public Search tool, Global Dossier, and databases from other international intellectual property offices like the EPO and JPO[1].
Q: What is the significance of the Common Citation Document (CCD) in patent searching?
A: The CCD consolidates prior art cited by multiple offices for the same invention, facilitating a more comprehensive search across different jurisdictions[1].
Q: How can patent holders commercialize their inventions effectively?
A: Patent holders can license their technology, collaborate with other companies, and navigate regulatory environments to bring their products to market.
