Details for Patent: 8,133,893

Which drugs does patent 8,133,893 protect, and when does it expire?

Patent 8,133,893 protects OLEPTRO and DESYREL and is included in two NDAs.

This patent has thirty-two patent family members in twenty-three countries.

Summary for Patent: 8,133,893

Title:	Trazodone and trazodone hydrochloride in purified form
Abstract:	A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40.degree. C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride. ##STR00001##
Inventor(s):	Marchetti; Marcello (Rome, IT), Iacoangeli; Tommaso (Rome, IT), Ciottoli; Giovanni Battista (Rome, IT), Biondi; Giuseppe (Castel Gandolfo, IT)
Assignee:	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (Rome, IT)
Application Number:	12/513,048
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,133,893
Patent Claim Types: see list of patent claims	Compound; Composition; Use; Process;

Drugs Protected by US Patent 8,133,893

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Angelini Pharma	OLEPTRO	trazodone hydrochloride	TABLET, EXTENDED RELEASE;ORAL	022411-001	Feb 2, 2010		DISCN	Yes	No			Y	Y
Angelini Pharma	OLEPTRO	trazodone hydrochloride	TABLET, EXTENDED RELEASE;ORAL	022411-002	Feb 2, 2010		DISCN	Yes	No			Y	Y
Pragma	DESYREL	trazodone hydrochloride	TABLET;ORAL	018207-001	Approved Prior to Jan 1, 1982		DISCN	Yes	No			Y	Y
Pragma	DESYREL	trazodone hydrochloride	TABLET;ORAL	018207-002	Approved Prior to Jan 1, 1982		DISCN	Yes	No			Y	Y
Pragma	DESYREL	trazodone hydrochloride	TABLET;ORAL	018207-003	Mar 25, 1985		DISCN	Yes	No			Y	Y
Pragma	DESYREL	trazodone hydrochloride	TABLET;ORAL	018207-004	Nov 7, 1988		DISCN	Yes	No			Y	Y

Foreign Priority and PCT Information for Patent: 8,133,893

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
Italy	MI2007A1603	Aug 03, 2007

PCT Information
PCT Filed	July 23, 2008	PCT Application Number:	PCT/EP2008/059640
PCT Publication Date:	February 12, 2009	PCT Publication Number:	WO2009/019133

International Family Members for US Patent 8,133,893

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Argentina	067773
Australia	2008285779
Brazil	PI0814448
Canada	2693095
China	101772490
Cyprus	1115666