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Last Updated: November 4, 2024

Details for Patent: 8,178,693


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Summary for Patent: 8,178,693
Title:N3 alkylated benzimidazole derivatives as MEK inhibitors
Abstract: Disclosed are compounds of the Formula ##STR00001## and pharmaceutically acceptable salts and prodrugs thereof, wherein A, R.sup.1, R.sup.2, R.sup.7, R.sup.8, and R.sup.9 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
Inventor(s): Wallace; Eli M. (Boulder, CO), Lyssikatos; Joseph P. (Piedmont, CA), Marlow; Allison L. (Boulder, CO), Hurley; T. Brian (Boulder, CO)
Assignee: Array Biopharma Inc. (Boulder, CO)
Application Number:12/824,559
Patent Claim Types:
see list of patent claims
Composition; Compound;

Drugs Protected by US Patent 8,178,693

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Astrazeneca KOSELUGO selumetinib sulfate CAPSULE;ORAL 213756-001 Apr 10, 2020 RX Yes No ⤷  Sign Up ⤷  Sign Up Y Y ⤷  Sign Up
Astrazeneca KOSELUGO selumetinib sulfate CAPSULE;ORAL 213756-002 Apr 10, 2020 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y Y ⤷  Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,178,693

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1482932 ⤷  Sign Up PA2019007 Lithuania ⤷  Sign Up
European Patent Office 1482932 ⤷  Sign Up LUC00100 Luxembourg ⤷  Sign Up
European Patent Office 1482932 ⤷  Sign Up 300974 Netherlands ⤷  Sign Up
European Patent Office 1482932 ⤷  Sign Up 2019C/510 Belgium ⤷  Sign Up
European Patent Office 1482932 ⤷  Sign Up CA 2019 00011 Denmark ⤷  Sign Up
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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