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Last Updated: March 13, 2025

Details for Patent: 9,974,781


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Summary for Patent: 9,974,781
Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Hadida Ruah; Sara Sabina (La Jolla, CA), Grootenhuis; Peter Diederik Jan (San Diego, CA), Van Goor; Fredrick F. (San Diego, CA), Zhou; Jinglan (San Diego, CA), Bear; Brian Richard (Carlsbad, CA), Miller; Mark Thomas (San Diego, CA), McCartney; Jason (Cardiff by the Sea, CA), Numa; Mehdi Michel Djamel (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Application Number:15/234,877
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

United States Patent 9,974,781: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 9,974,781, titled "Modulators of ATP-binding cassette transporters," is a significant patent in the field of pharmaceuticals, particularly in the treatment of various diseases and disorders. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Overview of the Patent

Invention Description

The patent describes compounds and pharmaceutically acceptable compositions that are useful for treating or lessening the severity of a variety of diseases, disorders, or conditions. These compounds are modulators of ATP-binding cassette (ABC) transporters, which play crucial roles in the transport of various substances across cell membranes[4].

Publication and Legal Status

The patent was published on May 22, 2018, and is currently active. However, the legal status listed is an assumption and not a legal conclusion, as indicated by Google Patents[4].

Scope of the Patent

Therapeutic Applications

The patent covers a wide range of therapeutic applications, including the treatment of diseases such as cancer, inflammatory disorders, and neurological conditions. The modulators of ABC transporters are designed to either inhibit or enhance the activity of these transporters, depending on the specific therapeutic goal[4].

Chemical Compounds

The patent details various chemical compounds that act as modulators of ABC transporters. These compounds are described in terms of their structural formulas and synthetic methods. The patent also includes examples of how these compounds can be formulated into pharmaceutical compositions[4].

Claims of the Patent

Independent Claims

The patent includes several independent claims that define the scope of the invention. These claims cover the chemical compounds themselves, methods of using these compounds for therapeutic purposes, and pharmaceutical compositions containing these compounds[4].

Dependent Claims

Dependent claims further specify the scope by detailing specific embodiments of the invention, such as particular chemical structures, dosages, and methods of administration. These claims help to narrow down the invention and provide additional protection against infringement[4].

Patent Landscape

Prior Art

The patent cites prior art related to ABC transporters and their modulators. This includes previous patents and publications that describe the role of ABC transporters in various diseases and the development of modulators. The patent distinguishes itself from prior art by describing novel compounds and their specific therapeutic applications[4].

International Patents

The invention is also protected by international patents. For instance, the patent is part of a family of patents filed in various jurisdictions, including the European Patent Office (EPO) and the Japan Patent Office (JPO). This ensures global protection for the invention[5].

Competitor Patents

The patent landscape in the field of ABC transporter modulators is competitive, with several other patents and patent applications filed by different entities. These patents cover similar therapeutic areas and often describe overlapping or complementary technologies[1].

Search and Analysis Tools

USPTO Resources

To conduct a thorough analysis of the patent landscape, one can use resources provided by the United States Patent and Trademark Office (USPTO). The Patent Public Search tool, for example, allows users to search for prior art and related patents. The Global Dossier service provides access to file histories of related applications from participating IP offices[1].

International Databases

Other international databases such as the European Patent Office's esp@cenet and the World Intellectual Property Organization's (WIPO) PATENTSCOPE can also be used to search for international patents and prior art[1].

Economic and Strategic Implications

Market Impact

The patent has significant market implications, particularly in the pharmaceutical industry. The compounds described in the patent could lead to the development of new drugs, which could disrupt existing markets and create new opportunities for pharmaceutical companies[4].

Licensing and Collaboration

The patent holder may choose to license the technology to other companies, which could lead to collaborations and partnerships in the development and commercialization of the compounds. This can also impact the competitive landscape by allowing multiple companies to develop and market similar products[3].

Conclusion

United States Patent 9,974,781 is a critical patent in the field of pharmaceuticals, offering novel compounds and therapeutic applications for the modulation of ABC transporters. Understanding the scope, claims, and broader patent landscape is essential for any entity looking to navigate this complex and competitive field.

Key Takeaways

  • The patent covers modulators of ATP-binding cassette transporters for various therapeutic applications.
  • It includes detailed descriptions of chemical compounds and pharmaceutical compositions.
  • The patent is part of a global patent family, ensuring protection in multiple jurisdictions.
  • The competitive landscape is marked by several other patents and patent applications in the same field.
  • Economic implications include potential market disruption and opportunities for licensing and collaboration.

FAQs

1. What is the main subject of United States Patent 9,974,781?

The main subject of the patent is the description of compounds and pharmaceutical compositions that act as modulators of ATP-binding cassette (ABC) transporters.

2. What are the therapeutic applications of the compounds described in the patent?

The compounds are useful for treating or lessening the severity of various diseases, including cancer, inflammatory disorders, and neurological conditions.

3. How can one search for related patents and prior art?

One can use resources such as the USPTO's Patent Public Search tool, Global Dossier, and international databases like esp@cenet and PATENTSCOPE.

4. What is the current legal status of the patent?

The patent is currently active, but the legal status listed is an assumption and not a legal conclusion.

5. What are the economic implications of this patent?

The patent could lead to the development of new drugs, disrupt existing markets, and create new opportunities for pharmaceutical companies through licensing and collaboration.

Sources

  1. USPTO - Search for patents. Retrieved from https://www.uspto.gov/patents/search
  2. U.S. Patent and Trademark Office (USPTO) | USAGov. Retrieved from https://www.usa.gov/agencies/u-s-patent-and-trademark-office
  3. Patent and patent application Claims data (Stata (.dta) and MS Excel .... Retrieved from https://developer.uspto.gov/product/patent-and-patent-application-claims-data-stata-dta-and-ms-excel-csv
  4. US9974781B2 - Modulators of ATP-binding cassette transporters. Retrieved from https://patents.google.com/patent/US9974781B2/en
  5. Drugs covered by patent 9,974,781. Claims, international patent .... Retrieved from https://www.drugpatentwatch.com/p/patent/9974781

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Drugs Protected by US Patent 9,974,781

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International Family Members for US Patent 9,974,781

CountryPatent NumberEstimated ExpirationSupplementary Protection CertificateSPC CountrySPC Expiration
Australia 2007235260 ⤷  Try for Free
Brazil PI0710965 ⤷  Try for Free
Canada 2648719 ⤷  Try for Free
Canada 2869945 ⤷  Try for Free
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