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Last Updated: March 26, 2025

CALAN Drug Patent Profile


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Which patents cover Calan, and what generic alternatives are available?

Calan is a drug marketed by Gd Searle Llc and Pfizer and is included in three NDAs.

The generic ingredient in CALAN is verapamil hydrochloride. There are seventeen drug master file entries for this compound. Forty-three suppliers are listed for this compound. Additional details are available on the verapamil hydrochloride profile page.

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Drug patent expirations by year for CALAN
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US Patents and Regulatory Information for CALAN

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Exclusivity Expiration
Pfizer CALAN verapamil hydrochloride TABLET;ORAL 018817-002 Sep 10, 1984 DISCN Yes No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Pfizer CALAN verapamil hydrochloride TABLET;ORAL 018817-003 Feb 23, 1988 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Gd Searle Llc CALAN verapamil hydrochloride INJECTABLE;INJECTION 019038-001 Mar 30, 1984 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Pfizer CALAN SR verapamil hydrochloride TABLET, EXTENDED RELEASE;ORAL 019152-001 Dec 16, 1986 DISCN Yes No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Pfizer CALAN SR verapamil hydrochloride TABLET, EXTENDED RELEASE;ORAL 019152-002 Dec 15, 1989 DISCN Yes No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Exclusivity Expiration
Showing 1 to 5 of 5 entries

Market Dynamics and Financial Trajectory for Calan (Verapamil)

Introduction to Calan (Verapamil)

Calan, also known by its generic name verapamil, is a calcium channel blocker commonly used to treat conditions such as high blood pressure, angina, and certain types of arrhythmias. Understanding the market dynamics and financial trajectory of Calan is crucial for pharmaceutical companies, investors, and healthcare providers.

Market Size and Growth

The global market for cardiovascular disease drugs, which includes Calan, is projected to grow significantly. From $55.32 billion in 2022, the market is expected to reach $78.791 billion by 2030, with a Compound Annual Growth Rate (CAGR) of 4.52% during the forecast period of 2022-2030[1].

Market Drivers

Several factors drive the demand for cardiovascular drugs like Calan:

  • Increasing Incidence of Cardiovascular Diseases: The rising prevalence of cardiovascular diseases due to factors such as sedentary lifestyles, unhealthy diets, increased tobacco consumption, and an aging population drives the demand for these drugs[1].
  • Research and Development: Continuous R&D in the pharmaceutical sector leads to the development of new and more effective treatments, which can include improved formulations of existing drugs like Calan.
  • Government Initiatives: Campaigns and initiatives by governments to raise awareness about early detection and timely management of cardiovascular diseases also contribute to the growing demand[1].

Generic Competition

Calan, being a well-established drug, has generic versions available. Generic verapamil is significantly cheaper than the branded version, which affects the pricing and profitability of Calan. For instance, the generic version of verapamil can cost as low as $20.30 for 90 tablets, compared to the branded Calan which can cost around $329.90 for 100 tablets[2][5].

Price Dynamics

The prices of Calan and its generic versions are influenced by several factors:

  • Competition: The presence of multiple generic competitors drives down the prices. Studies have shown that generic drug prices fall with the number of competitors and approach long-run marginal costs when there are 8 or more competitors[4].
  • Regulatory Environment: Changes in FDA policies, such as increased scrutiny of generic drug applications, can affect the cost and timing of generic drug entry into the market[4].
  • Supply and Demand: Stock shortages and other market variables can cause price fluctuations. For example, the cost of Calan SR (extended release) can range from $649.89 to $993.14 for 100 tablets, depending on the dosage and availability[5].

Financial Impact on Pharmaceutical Companies

The financial trajectory of Calan is influenced by its market position and the competitive landscape:

  • Revenue from Branded vs. Generic Versions: Pharmaceutical companies earn higher revenues from branded drugs like Calan but face significant competition from generic versions. The availability of generic verapamil reduces the market share and revenue of the branded version.
  • Cost of Production and Distribution: The cost of producing and distributing Calan, including research and development expenses, marketing, and regulatory compliance, affects the profitability of the drug.
  • Discounts and Patient Assistance Programs: Programs like the Drugs.com Discount Card can save patients up to 80% on prescription medicines, which can impact the revenue generated from Calan sales[2][5].

Impact of Government Policies and Initiatives

Government policies and initiatives play a crucial role in shaping the market dynamics of cardiovascular drugs:

  • Regulatory Approvals: Changes in FDA policies, such as simultaneous approval of multiple generic entrants, can reduce prices and affect the competitive landscape[4].
  • Awareness Campaigns: Government campaigns to raise awareness about cardiovascular diseases can increase demand for drugs like Calan but also emphasize the importance of early detection and prevention, potentially reducing long-term demand for treatment[1].

Consumer and Patient Factors

Consumer behavior and patient needs also influence the market:

  • Patient Compliance: The availability of extended-release formulations like Calan SR can improve patient compliance, which can positively impact sales and revenue.
  • Cost Sensitivity: Patients are often cost-sensitive, which makes generic versions more appealing. This can shift market share from branded to generic versions[2][5].

Future Outlook

The future outlook for Calan and similar cardiovascular drugs is promising due to the increasing prevalence of cardiovascular diseases. However, the market will continue to be competitive, with generic versions playing a significant role. Pharmaceutical companies will need to focus on R&D to develop new treatments and formulations to maintain market share.

Key Takeaways

  • The global cardiovascular disease drugs market is growing, driven by increasing incidence of cardiovascular diseases and government initiatives.
  • Generic competition significantly affects the pricing and profitability of branded drugs like Calan.
  • Regulatory policies and consumer behavior influence the market dynamics and financial trajectory of Calan.
  • Pharmaceutical companies must invest in R&D to stay competitive in the market.

Frequently Asked Questions

Q: What is Calan used for?

A: Calan (verapamil) is used to treat high blood pressure, angina, and certain types of arrhythmias.

Q: How does the availability of generic verapamil affect the market for Calan?

A: The availability of generic verapamil significantly reduces the price and market share of the branded version, Calan, making it more competitive.

Q: What are the key drivers of the cardiovascular disease drugs market?

A: The key drivers include the increasing incidence of cardiovascular diseases, research and development of new drugs, and government initiatives for early detection and management.

Q: How do regulatory policies impact the market for Calan?

A: Regulatory policies, such as FDA approvals and scrutiny of generic drug applications, can affect the cost, timing, and competition in the market.

Q: What is the future outlook for Calan and similar cardiovascular drugs?

A: The future outlook is promising due to the growing prevalence of cardiovascular diseases, but the market will remain competitive with a significant role for generic versions.

Cited Sources:

  1. Insights10 - Global Cardiovascular Disease Drugs Market Analysis
  2. Drugs.com - Calan Prices, Coupons, Copay Cards & Patient Assistance
  3. Philip Morris International - PMI Integrated Report 2022
  4. Federal Trade Commission - Generic Drug Industry Dynamics
  5. Drugs.com - Calan SR Prices, Coupons, Copay Cards & Patient Assistance

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