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Last Updated: January 7, 2025

EDECRIN Drug Patent Profile


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Which patents cover Edecrin, and what generic alternatives are available?

Edecrin is a drug marketed by Bausch and is included in two NDAs.

The generic ingredient in EDECRIN is ethacrynic acid. There are thirteen drug master file entries for this compound. Ten suppliers are listed for this compound. Additional details are available on the ethacrynic acid profile page.

DrugPatentWatch® Litigation and Generic Entry Outlook for Edecrin

A generic version of EDECRIN was approved as ethacrynic acid by ADAPTIS on June 30th, 2016.

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Summary for EDECRIN
Drug patent expirations by year for EDECRIN
Drug Prices for EDECRIN

See drug prices for EDECRIN

Recent Clinical Trials for EDECRIN

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Eugene Lee, MDPhase 1
University of Kansas Medical CenterPhase 1

See all EDECRIN clinical trials

Pharmacology for EDECRIN
Drug ClassLoop Diuretic
Physiological EffectIncreased Diuresis at Loop of Henle

US Patents and Regulatory Information for EDECRIN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Bausch EDECRIN ethacrynate sodium INJECTABLE;INJECTION 016093-001 Approved Prior to Jan 1, 1982 AP RX Yes Yes ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Bausch EDECRIN ethacrynic acid TABLET;ORAL 016092-001 Approved Prior to Jan 1, 1982 AB RX Yes Yes ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Bausch EDECRIN ethacrynic acid TABLET;ORAL 016092-002 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

EDECRIN Market Analysis and Financial Projection

Market Dynamics and Financial Trajectory for Edecrin (Ethacrynic Acid)

Market Overview of Edecrin

Edecrin, also known as ethacrynic acid, is a potent diuretic used primarily to manage conditions such as congestive heart failure and edema. Here are some key aspects of its market dynamics:

Increasing Prevalence of Target Conditions

The market for Edecrin is driven by the increasing prevalence of conditions like congestive heart failure and edema. As the global population ages and the incidence of these conditions rises, the demand for effective diuretics like Edecrin is expected to grow[1].

Unique Selling Points

Edecrin stands out due to its suitability for patients with sulfa allergies, which sets it apart from other diuretics. This unique selling point expands its market demand and makes it a preferred choice in certain patient populations[1].

Emerging Therapeutic Applications

Ongoing research into new applications for Edecrin, such as reducing cisplatin-induced nephrotoxicity in cancer treatment, further enhances its market potential. These emerging uses could significantly expand the drug's market reach and revenue[1].

Trends in the Pharmaceutical Industry

Personalized Medicine

There is a growing emphasis on personalized medicine, which may influence the usage of Edecrin. Tailored dosages and combinations with other drugs could become more prevalent, potentially impacting the drug's market position and financial trajectory[1].

Advancements in Drug Delivery

Advancements in drug delivery mechanisms and formulations are expected to improve patient compliance and marketability of Edecrin. New delivery systems could make the drug more convenient and effective, thereby increasing its adoption[1].

Financial Performance and Market Dynamics

Revenue and Sales

The financial performance of Edecrin is tied to the overall revenue generated by its sales. Companies like Bausch Health, which may have Edecrin or similar products in their portfolio, report significant revenues from their pharmaceutical divisions. For instance, Bausch Health's diversified portfolio, which includes various pharmaceutical products, generated substantial revenue in recent years[3].

Cost Structure and Profit Margins

The cost structure for manufacturing Edecrin includes raw material costs, utility requirements, infrastructure, machinery, and manpower. The report by IMARC Group provides detailed insights into these costs and the expected profit margins. The industry profit margins are influenced by the price analysis of feedstocks and the overall efficiency of the manufacturing process[1].

Pricing Dynamics

The pricing of Edecrin, like other brand-name prescription drugs, can be subject to extraordinary price increases due to factors such as patent protection, market exclusivity, and limited competition. According to the GAO report, many brand-name drugs, including those in the same therapeutic class as Edecrin, have experienced significant price increases over the years[4].

Factors Influencing Pricing

Patent Protection and Market Exclusivity

Patent protection and market exclusivity play crucial roles in the pricing of Edecrin. These factors temporarily limit competition, allowing drug companies to recoup research and development costs and earn a return on their investment[4].

Consolidation in the Pharmaceutical Industry

The consolidation among drug companies through mergers and acquisitions can lead to fewer companies producing and marketing drugs, resulting in greater market domination and less competition. This can contribute to higher prices for drugs like Edecrin[4].

Demand and Supply Dynamics

Healthcare providers often influence demand for prescription drugs, and patients may remain unaware of the drug costs due to insurance coverage. This can lead to a scenario where demand is less sensitive to price increases, allowing companies to maintain higher prices[4].

Financial Trajectory of Bausch Health

Debt Reduction and Financial Restructuring

Bausch Health, a company that may have interests in drugs like Edecrin, has been focused on improving its capital structure. The company has made significant debt repayments and has reduced its long-term debt by approximately $10 billion since 2016. This financial restructuring positions the company for better financial health and potentially more robust investment in its pharmaceutical portfolio[5].

Revenue Growth and EBITDA

Bausch Health reported substantial revenues and adjusted EBITDA in recent years. For example, in 2022, the company's revenues totaled $4.36 billion, with an adjusted EBITDA margin of 53.2%. This financial performance indicates a strong foundation for investing in and growing its pharmaceutical products, including those in the diuretic segment[3].

Key Takeaways

  • Increasing Demand: The market for Edecrin is driven by the increasing prevalence of conditions like congestive heart failure and edema.
  • Unique Selling Points: Edecrin's suitability for patients with sulfa allergies and its potential in emerging therapeutic areas enhance its market position.
  • Pricing Dynamics: The drug's pricing is influenced by patent protection, market exclusivity, and industry consolidation.
  • Financial Performance: Companies like Bausch Health report significant revenues and have been focused on improving their financial health through debt reduction and restructuring.
  • Trends in Personalized Medicine and Drug Delivery: These trends may further enhance the market position and financial trajectory of Edecrin.

FAQs

What are the primary uses of Edecrin?

Edecrin is primarily used to manage conditions such as congestive heart failure and edema due to its potent diuretic properties.

Why is Edecrin preferred over other diuretics?

Edecrin is preferred for patients with sulfa allergies, making it a unique option in the diuretic market.

What are the emerging therapeutic applications of Edecrin?

Edecrin is being researched for new applications, including reducing cisplatin-induced nephrotoxicity in cancer treatment.

How do industry trends impact the market for Edecrin?

Trends in personalized medicine and advancements in drug delivery mechanisms are expected to improve patient compliance and marketability of Edecrin.

What factors contribute to the pricing of Edecrin?

Pricing is influenced by patent protection, market exclusivity, limited competition, and industry consolidation.

Sources

  1. IMARC Group: "Ethacrynic Acid (Edecrin) Manufacturing Plant Project Report 2024: Industry Trends, Plant Setup, Machinery, Raw Materials, Investment Opportunities, Cost and Revenue."
  2. Bausch Health Companies Inc.: "Form: 10-Q, Received."
  3. Bausch Health Companies Inc.: "2022 ANNUAL REPORT."
  4. GAO: "GAO-10-201, Brand-Name Prescription Drug Pricing."
  5. Marketscreener: "BAUSCH HEALTH COMPANIES INC. Management's Discussion and Analysis of Financial Condition and Results."

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