ISOPAQUE 440 Drug Patent Profile

When do Isopaque 440 patents expire, and what generic alternatives are available?

Isopaque 440 is a drug marketed by Ge Healthcare and is included in one NDA.

The generic ingredient in ISOPAQUE 440 is calcium metrizoate; meglumine metrizoate; metrizoate magnesium; metrizoate sodium. There are two hundred and eighty-two drug master file entries for this compound. Additional details are available on the calcium metrizoate; meglumine metrizoate; metrizoate magnesium; metrizoate sodium profile page.

Summary for ISOPAQUE 440

US Patents:	0
Applicants:	1
NDAs:	1
Raw Ingredient (Bulk) Api Vendors:	70
Patent Applications:	1,658
DailyMed Link:	ISOPAQUE 440 at DailyMed

US Patents and Regulatory Information for ISOPAQUE 440

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Ge Healthcare	ISOPAQUE 440	calcium metrizoate; meglumine metrizoate; metrizoate magnesium; metrizoate sodium	INJECTABLE;INJECTION	016847-001	Approved Prior to Jan 1, 1982		DISCN	No	No

Expired US Patents for ISOPAQUE 440

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Ge Healthcare	ISOPAQUE 440	calcium metrizoate; meglumine metrizoate; metrizoate magnesium; metrizoate sodium	INJECTABLE;INJECTION	016847-001	Approved Prior to Jan 1, 1982

International Patents for ISOPAQUE 440

See the table below for patents covering ISOPAQUE 440 around the world.

Country	Patent Number	Title	Estimated Expiration
United Kingdom	973881
Denmark	125282
Finland	40563
Germany	1192369	Roentgenkontrastmittel
France	1548251
Germany	1518051
Netherlands	6803180

Supplementary Protection Certificates for ISOPAQUE 440

Patent Number	Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
2365988	122018000012	Germany		PRODUCT NAME: PATIROMER SORBITEX CALCIUM UND SALZE DAVON IN ALLEN VOM GRUNDPATENT GESCHUETZTEN FORMEN; REGISTRATION NO/DATE: EU/1/17/1179 20170719
0720599	300689	Netherlands		PRODUCT NAME: EZETIMIBE, DESGEWENST IN DE VORM VAN EEN FARMACEUTISCH AANVAARDBAAR ZOUT, EN ATORVASTATINE, DESGEWENST IN DE VORM VAN EEN FARMACEUTISCH AANVAARDBAAR ZOUT, IN HET BIJZONDER ATORVASTATINE CALCIUM TRIHYDRATE; NATIONAL REGISTRATION NO/DATE: RVG114373-114376 20141027; FIRST REGISTRATION: FR 2014091200122 20140912
2365988	CA 2018 00006	Denmark		PRODUCT NAME: PATIROMER SORBITEX CALCIUM AND ANY SALTS AND DERIVATIVES THEREOF; REG. NO/DATE: EU/1/17/1179/001-009 20170721
0933372	SPC/GB08/018	United Kingdom		PRODUCT NAME: FOSAMPRENAVIR CALCIUM: ((1S,2R)-3-(((4-AMINOPHENYL)SULFONYL)(2-METHYLPROPYL)AMINO)-1-(PHENYLMETHYL)-2(PHOSPHONOOXY)PROPYL)-CARBABAMIC ACID C-((3S)-TETRAHYDRO-3-FURANYL) ESTER CALCIUM SALT; REGISTERED: UK EU/1/04/282/001 20040712; UK EU/1/04/282/002 20040712
2365988	2018C/006	Belgium		PRODUCT NAME: PATIROMER SORBITEX CALCIUM OF EERDER WELK ZOUT OF AFGELEIDE ERVAN; AUTHORISATION NUMBER AND DATE: EU/1/17/1179 20170721
0521471	C300125	Netherlands		PRODUCT NAME: ROSUVASTATINUM, DESGEWENST IN DE VORM VAN EEN NIET-TOXISCH FARMACEUTISCH AANVAARDBAAR ZOUT, IN HET BIJZONDER HET CALCIUMZOUT; REGISTRATION NO/DATE: RVG 26872 - RVG 26874 20021106
2957286	300962	Netherlands		PRODUCT NAME: PATIROMER SORBITEX CALCIUM; REGISTRATION NO/DATE: EU/1/17/1179 20170721

ISOPAQUE 440 Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for the Drug: ISOPAQUE 440

Introduction

Understanding the market dynamics and financial trajectory of a specific drug, such as ISOPAQUE 440, involves analyzing various factors including market trends, competitive landscape, regulatory environment, and financial performance. Here, we will delve into these aspects to provide a comprehensive overview.

Market Trends in the Pharmaceutical Industry

Dynamic Nature of Pharmaceutical Markets

Pharmaceutical markets are inherently dynamic, influenced by factors such as technological advancements, regulatory changes, and shifting consumer demands. For instance, the emergence of new drugs and therapies can significantly alter market dynamics, similar to how fentanyl and its analogues have impacted the opioid market[3].

Impact of Regulatory Environment

Regulatory policies play a crucial role in shaping the market trajectory of pharmaceuticals. Strict regulations and enforcement can influence the production, distribution, and pricing of drugs. For ISOPAQUE 440, any changes in regulatory requirements or enforcement strategies could impact its market position and financial performance.

Competitive Landscape

Existing Competitors

The market for contrast agents like ISOPAQUE 440 is competitive, with several established players. Companies such as GE Healthcare, Bracco, and Bayer HealthCare Pharmaceuticals are key competitors in this space. The competitive pressure from these firms can drive innovation and pricing strategies for ISOPAQUE 440.

New Entrants and Innovations

New entrants and innovative products can disrupt the market. For example, the acquisition of PowerReviews by Bazaarvoice highlights how companies can expand their offerings and compete more effectively in a dynamic market[1]. Similarly, new contrast agents or imaging technologies could challenge ISOPAQUE 440's market share.

Financial Performance and Trajectory

Revenue and Market Share

The financial performance of ISOPAQUE 440 would be closely tied to its market share and revenue growth. Factors such as pricing strategies, customer demand, and competitive pressures would influence its revenue. For instance, if ISOPAQUE 440 faces significant competition from new or existing products, its revenue and market share could be impacted.

Cost Structure and Profitability

The cost structure, including production costs, marketing expenses, and research and development investments, would be crucial in determining the profitability of ISOPAQUE 440. Companies like Zillow, which have seen significant fluctuations in their financial performance due to market conditions and investment strategies, illustrate the importance of managing costs and investments[2].

Customer Demand and Switching Behavior

Customer Preferences and Loyalty

Customer demand for ISOPAQUE 440 would be influenced by factors such as efficacy, safety, and cost. Customer loyalty and switching behavior are critical, as seen in the case of Bazaarvoice where customers had numerous competitive options and did not expect harm from the acquisition of PowerReviews[1].

Impact of Customer Switching

Vigorous customer switching, as observed in the social commerce space, can keep pricing pressure on companies. For ISOPAQUE 440, if customers have multiple alternatives and are willing to switch, this could maintain competitive pricing and prevent anticompetitive price changes.

Research and Development (R&D) Investments

Innovation and Market Position

Continuous innovation is essential for maintaining a strong market position. Companies that invest heavily in R&D, like Bazaarvoice, are better positioned to compete against new entrants and existing competitors[1]. For ISOPAQUE 440, significant R&D investments would be necessary to stay competitive and address emerging market needs.

Regulatory and Compliance Issues

Regulatory Oversight

Regulatory oversight is a critical factor in the pharmaceutical industry. Compliance with regulatory requirements is essential for maintaining market approval and avoiding legal and financial repercussions. Any changes in regulatory policies or enforcement could significantly impact ISOPAQUE 440's market dynamics and financial trajectory.

Global Market Considerations

Regional Market Dynamics

Market dynamics can vary significantly across different regions. For instance, the drug market trends in North America, influenced by factors like fentanyl and policy changes, differ from those in other parts of the world[3]. Understanding these regional dynamics is crucial for a global product like ISOPAQUE 440.

Economic and Policy Factors

Economic conditions and policy changes in different regions can affect the demand and supply of pharmaceuticals. The Adaptive Markets Hypothesis, which suggests that markets adapt to new information and conditions, highlights the need for continuous monitoring of economic and policy factors[5].

Key Takeaways

• Dynamic Market Environment: Pharmaceutical markets are dynamic and influenced by various factors including technological advancements, regulatory changes, and consumer demands.
• Competitive Landscape: The market for contrast agents is competitive, with existing and new entrants driving innovation and pricing strategies.
• Financial Performance: Revenue, market share, cost structure, and profitability are critical for the financial trajectory of ISOPAQUE 440.
• Customer Demand: Customer preferences, loyalty, and switching behavior play a significant role in maintaining competitive pricing.
• R&D Investments: Continuous innovation through R&D investments is essential for staying competitive.
• Regulatory Compliance: Compliance with regulatory requirements is crucial for maintaining market approval and avoiding legal and financial repercussions.

FAQs

Q: What are the key factors influencing the market dynamics of pharmaceuticals like ISOPAQUE 440? A: Key factors include technological advancements, regulatory changes, consumer demands, and competitive pressures.

Q: How does the competitive landscape impact the financial performance of ISOPAQUE 440? A: The competitive landscape drives innovation, pricing strategies, and customer switching behavior, all of which impact revenue and profitability.

Q: What role does R&D play in the market trajectory of ISOPAQUE 440? A: R&D investments are crucial for maintaining a competitive edge and addressing emerging market needs.

Q: How do regional market dynamics affect the global market for ISOPAQUE 440? A: Regional market dynamics, influenced by economic conditions and policy changes, can significantly impact demand and supply.

Q: What is the importance of regulatory compliance for ISOPAQUE 440? A: Regulatory compliance is essential for maintaining market approval and avoiding legal and financial repercussions.

Sources

1. Bazaarvoice Acquisition of PowerReviews: Applied Antitrust, "Bazaarvoice ND Cal FF Def11 5 2013" [PDF].
2. Zillow Financial Results: Zillow, "Q4 2022 Shareholders' Letter" [PDF].
3. Drug Market Trends: PubMed, "Shifting drug markets in North America - a global crisis in the making?".
4. Pivotal Financial Metrics: Court of Chancery of the State of Delaware, "Pivotal Financial Metrics".
5. Adaptive Markets Hypothesis: MIT Sloan Virtual Reunion 2021, "Making Sense of Financial Market Dynamics in a Post-COVID World".