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Last Updated: April 11, 2025

Details for Patent: 11,680,069


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Which drugs does patent 11,680,069 protect, and when does it expire?

Patent 11,680,069 protects RINVOQ LQ and RINVOQ and is included in two NDAs.

This patent has fifty patent family members in thirteen countries.

Summary for Patent: 11,680,069
Title:Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
Abstract:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.
Inventor(s):Ayman ALLIAN, Fredrik Lars NORDSTROM, Ahmad Y. Sheikh, Thomas B. Borchardt
Assignee:AbbVie Inc
Application Number:US17/951,332
Patent Claim Types:
see list of patent claims
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 11,680,069

Introduction

United States Patent 11,680,069, titled "Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof," is a patent that delves into the synthesis and preparation of a specific chemical compound. Here, we will conduct a detailed analysis of the scope and claims of this patent, as well as the broader patent landscape it operates within.

Patent Overview

The patent in question, US11680069B2, describes processes for preparing a complex organic compound, specifically (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, and its solid state forms. This compound is likely of interest in pharmaceutical or chemical research due to its complex structure and potential biological activity.

Claims Analysis

Independent Claims

The patent includes several independent claims that define the scope of the invention. These claims typically cover the main processes and compounds described in the patent. For example:

  • Claim 1: This might cover the general process for preparing the compound, including specific steps and reagents used.
  • Claim 2: This could cover the solid state forms of the compound, including crystalline forms and their preparation methods.

Dependent Claims

Dependent claims further narrow down the scope by adding additional limitations to the independent claims. These might include:

  • Claim 3: A specific method for purifying the compound.
  • Claim 4: A particular solvent or reaction condition used in the process.

Scope of the Invention

The scope of the invention is defined by the claims and the detailed description provided in the patent. Here are some key aspects:

Processes

The patent details various processes for synthesizing the compound, including reaction conditions, reagents, and purification methods. These processes are critical for reproducing the compound and ensuring its quality and consistency[4].

Solid State Forms

The patent also covers the solid state forms of the compound, which are important for pharmaceutical applications. Solid state forms can affect the compound's stability, solubility, and bioavailability. The patent describes methods for preparing these forms, such as crystallization and polymorph screening[4].

Prior Art and Patent Landscape

To understand the novelty and non-obviousness of the patent, it is essential to consider the prior art and the broader patent landscape.

Prior Art

Prior art includes all publicly available information that existed before the patent application was filed. For chemical compounds, this often includes other patents, scientific literature, and databases like those provided by the USPTO, EPO, and WIPO. The Common Citation Document (CCD) tool can be particularly useful for consolidating prior art citations from multiple patent offices[1].

Related Patents

Searching databases such as Google Patents, the USPTO's Patent Public Search, and international patent databases can reveal related patents. For instance, other patents related to similar chemical structures or synthesis methods might be relevant. The Patent Claims Research Dataset provided by the USPTO can also offer insights into claim structures and trends in patent scope[3].

International Patent Landscape

Given the global nature of intellectual property, it is crucial to consider the international patent landscape.

  • Global Dossier: This service allows users to view the patent family for a specific application, including related applications filed at participating IP Offices. This can help in understanding the global protection and prior art related to the compound[1].
  • International Patent Offices: Databases from the European Patent Office (EPO), Japan Patent Office (JPO), and World Intellectual Property Organization (WIPO) provide access to international patent applications and grants, which can be used to assess the global patent landscape[1].

Economic and Practical Implications

The economic and practical implications of this patent are significant, particularly in the pharmaceutical industry.

  • Market Impact: The patent could influence the development of new drugs or therapeutic agents, affecting market competition and innovation.
  • Licensing and Collaboration: The patent holder may license the technology to other companies, fostering collaboration and further research in the field.

Key Takeaways

  • Detailed Processes: The patent provides detailed processes for synthesizing and purifying the compound.
  • Solid State Forms: It covers various solid state forms of the compound, crucial for pharmaceutical applications.
  • Prior Art and Landscape: Understanding prior art and the broader patent landscape is essential for assessing the novelty and non-obviousness of the patent.
  • International Considerations: The global patent landscape, including related applications and prior art, is vital for comprehensive analysis.
  • Economic Implications: The patent has significant economic and practical implications, particularly in the pharmaceutical industry.

FAQs

Q: What is the main subject of United States Patent 11,680,069? A: The main subject is the processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and its solid state forms.

Q: How can one search for prior art related to this patent? A: One can use tools like the USPTO's Patent Public Search, Global Dossier, and international patent databases such as those from the EPO, JPO, and WIPO.

Q: What is the significance of solid state forms in this patent? A: Solid state forms are crucial for pharmaceutical applications as they affect the compound's stability, solubility, and bioavailability.

Q: How does this patent impact the pharmaceutical industry? A: It could influence the development of new drugs, affect market competition, and foster collaboration and further research in the field.

Q: Where can one find detailed information on the processes described in the patent? A: The detailed description and claims sections of the patent provide comprehensive information on the processes and methods involved.

Sources

  1. USPTO - Search for patents: https://www.uspto.gov/patents/search
  2. ACUS - U.S. Patent Small Claims Court: https://www.acus.gov/research-projects/us-patent-small-claims-court
  3. USPTO - Patent Claims Research Dataset: https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
  4. Google Patents - US11680069B2: https://patents.google.com/patent/US11680069B2/en

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Drugs Protected by US Patent 11,680,069

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Patented / Exclusive UseSubmissiondate
Abbvie RINVOQ upadacitinib TABLET, EXTENDED RELEASE;ORAL 211675-001 Aug 16, 2019 RX Yes No 11,680,069 ⤷  Try for Free Y Y ⤷  Try for Free
Abbvie RINVOQ upadacitinib TABLET, EXTENDED RELEASE;ORAL 211675-002 Jan 14, 2022 RX Yes No 11,680,069 ⤷  Try for Free Y Y ⤷  Try for Free
Abbvie RINVOQ LQ upadacitinib SOLUTION;ORAL 218347-001 Apr 26, 2024 RX Yes Yes 11,680,069 ⤷  Try for Free Y ⤷  Try for Free
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Patented / Exclusive Use>Submissiondate
Showing 1 to 3 of 3 entries

International Family Members for US Patent 11,680,069

CountryPatent NumberEstimated ExpirationSupplementary Protection CertificateSPC CountrySPC Expiration
Australia 2016340167 ⤷  Try for Free
Australia 2020359635 ⤷  Try for Free
Australia 2021236570 ⤷  Try for Free
>Country>Patent Number>Estimated Expiration>Supplementary Protection Certificate>SPC Country>SPC Expiration
Showing 1 to 3 of 3 entries

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