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Last Updated: April 23, 2025

XYLOCAINE W/ EPINEPHRINE Drug Patent Profile


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When do Xylocaine W/ Epinephrine patents expire, and what generic alternatives are available?

Xylocaine W/ Epinephrine is a drug marketed by Astrazeneca and Fresenius Kabi Usa and is included in two NDAs.

The generic ingredient in XYLOCAINE W/ EPINEPHRINE is epinephrine; lidocaine hydrochloride. There are twenty-one drug master file entries for this compound. Eleven suppliers are listed for this compound. Additional details are available on the epinephrine; lidocaine hydrochloride profile page.

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Drug patent expirations by year for XYLOCAINE W/ EPINEPHRINE
Recent Clinical Trials for XYLOCAINE W/ EPINEPHRINE

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Vrije Universiteit BrusselPhase 4
University of AlbertaPhase 2
Ain Shams UniversityPhase 3

See all XYLOCAINE W/ EPINEPHRINE clinical trials

US Patents and Regulatory Information for XYLOCAINE W/ EPINEPHRINE

ApplicantTradenameGeneric NameDosageNDAApproval DateTETypeRLDRSPatent No.Patent ExpirationProductSubstanceDelist Req.Exclusivity Expiration
Fresenius Kabi Usa XYLOCAINE W/ EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 006488-012 Approved Prior to Jan 1, 1982 AP RX Yes Yes ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Fresenius Kabi Usa XYLOCAINE W/ EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 006488-019 Nov 13, 1986 AP RX Yes Yes ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Astrazeneca XYLOCAINE W/ EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 010418-006 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
>Applicant>Tradename>Generic Name>Dosage>NDA>Approval Date>TE>Type>RLD>RS>Patent No.>Patent Expiration>Product>Substance>Delist Req.>Exclusivity Expiration
Showing 1 to 3 of 3 entries

Market Dynamics and Financial Trajectory for XYLOCAINE with Epinephrine

Introduction

XYLOCAINE (lidocaine) with epinephrine is a widely used local anesthetic combination, employed in various medical procedures to provide anesthesia and reduce bleeding through vasoconstriction. Here, we will delve into the market dynamics and financial trajectory of this drug.

Market Overview

The global local anesthesia drugs market, which includes XYLOCAINE with epinephrine, is experiencing significant growth driven by several key factors.

Increasing Demand for Surgical Procedures

The rise in surgical procedures, including cosmetic, plastic, and dental surgeries, is a major driver. As the global population ages and health awareness increases, the demand for these procedures is on the rise. For instance, the global local anesthesia drugs market was valued at USD 4.01 billion in 2023 and is projected to grow at a CAGR of 3.6% from 2024 to 2030[3].

Growing Prevalence of Chronic Diseases

The increasing prevalence of chronic diseases, such as periodontal diseases, also contributes to the demand for local anesthetics like XYLOCAINE with epinephrine. The lidocaine market, in particular, is expected to reach USD 3.05 billion by 2029, growing at a CAGR of 8.45% from 2022 to 2029[4].

Product Specifics

XYLOCAINE with epinephrine is used in various forms, including injections, for different types of anesthesia.

Indications

XYLOCAINE solutions with epinephrine are indicated for local or regional anesthesia through techniques such as infiltration, peripheral nerve block, major plexus block, epidural block, and subarachnoid block[5].

Technological Advancements

Advancements in drug delivery technologies, such as computer-based local anesthetic delivery and vibrotactile devices, are expected to boost the market. For example, innovations like DepoFoam technology using bupivacaine liposome suspension for injection are enhancing the efficacy and safety of local anesthetics[3].

Market Segmentation

The market for XYLOCAINE with epinephrine can be segmented based on formulation, application, and distribution channels.

Formulation

The drug is available in various formulations, including injections, creams, ointments, and gels. Injectables account for the largest market revenue share due to their widespread use in surgical procedures[3].

Application

XYLOCAINE with epinephrine is primarily used in surgical procedures, including dental, cosmetic, and general surgeries. The anesthetic is also used for pain relief in minor cuts, skin scrapes, burns, and insect bites[4].

Distribution Channels

Hospital pharmacies hold a significant share of the distribution market due to higher patient footfall, insurance coverage, and the critical nature of the conditions treated[1].

Regional Analysis

The global market for local anesthetics, including XYLOCAINE with epinephrine, varies by region.

North America

North America is a leading market due to the high number of cosmetic and dental surgical procedures, as well as the growth in epilepsy cases. The region had the highest share of the worldwide market in 2020[4].

Asia-Pacific

The Asia-Pacific region is predicted to grow at the fastest rate, driven by the growing elderly population, increasing number of general surgeries, and expanding government healthcare activities[4].

Financial Trajectory

The financial outlook for XYLOCAINE with epinephrine is positive, driven by the growing demand for local anesthetics.

Market Size

The global lidocaine market, which includes XYLOCAINE with epinephrine, was valued at USD 1,482.78 million in 2020 and is expected to reach USD 3,058.92 million by 2029[4].

CAGR

The market is expected to grow at a CAGR of 8.45% from 2022 to 2029, driven by the increasing adoption of preventive healthcare solutions and the rising prevalence of periodontal diseases[4].

Key Drivers and Challenges

Several factors are driving the market forward, while some challenges also exist.

Key Drivers

  • Rising Prevalence of Chronic Diseases: The increasing prevalence of periodontal diseases and other chronic conditions is driving the demand for local anesthetics.
  • Growing Health Awareness: Increased health awareness and the adoption of preventive healthcare solutions are boosting the market.
  • Technological Advancements: Innovations in drug delivery technologies are enhancing the safety, efficacy, and ease of use of local anesthetics[3][4].

Challenges

  • Regulatory Policies: Stringent regulatory policies can impede market growth.
  • High Treatment Costs: The high costs associated with some local anesthetic treatments can be a barrier to adoption[4].

Competitive Landscape

The market for XYLOCAINE with epinephrine is competitive, with several key players.

Major Players

  • Teligent: Known for its FDA-approved lidocaine ointment and cream products.
  • Laborie: Another significant player in the local anesthetic market.
  • AstraZeneca: A major pharmaceutical company with a presence in the local anesthetic segment[4].

Key Takeaways

  • The global local anesthesia drugs market, including XYLOCAINE with epinephrine, is expected to grow significantly due to rising surgical procedures and chronic disease prevalence.
  • The market is driven by technological advancements, growing health awareness, and increasing adoption of preventive healthcare solutions.
  • North America and the Asia-Pacific region are key markets, with the latter expected to grow at the fastest rate.
  • The financial trajectory is positive, with the lidocaine market expected to reach USD 3.05 billion by 2029.

FAQs

1. What are the primary indications for XYLOCAINE with epinephrine? XYLOCAINE with epinephrine is indicated for local or regional anesthesia through techniques such as infiltration, peripheral nerve block, major plexus block, epidural block, and subarachnoid block[5].

2. What drives the demand for XYLOCAINE with epinephrine? The demand is driven by the increasing number of surgical procedures, growing prevalence of chronic diseases, and advancements in drug delivery technologies[3][4].

3. Which regions are expected to grow the fastest in the local anesthetic market? The Asia-Pacific region is predicted to grow at the fastest rate due to the growing elderly population and increasing healthcare expenditure[4].

4. What are the key challenges facing the XYLOCAINE with epinephrine market? Stringent regulatory policies and high treatment costs are significant challenges to market growth[4].

5. Who are the major players in the XYLOCAINE with epinephrine market? Major players include Teligent, Laborie, and AstraZeneca, among others[4].

Cited Sources:

  1. Coherent Market Insights: Epinephrine Market to Hit USD 6.27 Billion by 2031, Says Coherent Market Insights.
  2. Journal of the American Podiatric Medical Association: The Anesthetic Effects of Lidocaine with Epinephrine in Digital Nerve Blocks.
  3. Grand View Research: Local Anesthesia Drugs Market Size & Share Report, 2030.
  4. GlobeNewswire: Lidocaine Market Size is projected to reach USD 3.05 Billion by 2029, growing at a CAGR of 8.45%.
  5. Therapeutic Goods Administration (TGA): Approval lapsed - XYLOCAINE-MPF 2% with epinephrine 1:200,000.

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